Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as FOLFOX for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. more...
Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin®.
Side-effects of oxaliplatin treatment can potentially include:
- Neuropathy, specifically including sensitivity to cold and numbness in the hands and feet
- Nausea,vomiting, and/or diarrhea
- Hearing loss
In addition, some patients may experience an allergic reaction to platinum-containing drugs.
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