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Erythema multiforme

Stevens-Johnson syndrome (SJS) is a severe and potentially life-threatening (15% of cases) disease, it is a hypersensitivity complex affecting the skin and the mucous membranes, a severe expression of erythema multiforme (EM) (and so SJS is also called erythema multiforme major). more...

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Symptoms

SJS is characterized by fever, sore throat, and headache leading to the sudden development of circular mucocutaneous lesions (target lesions) that can cover the majority of the skin. These lesions begin as macules and can develop into papules, vesicles, blisters, or urticarial plaques. The most extreme cases are termed Toxic Epidermal Necrolysis Syndrome (TENS) or Lyell's Syndrome, in these cases the entire skin is affected.

Treatment

Treatment is initially similar to that of patients with thermal burns, and continued care can only be supportive (e.g. IV fluids) and symptomatic (e.g. analgesic mouth rinse for mouth ulcer); there is no specific drug treatment (2002). An ophthalmologist should be consulted if eyes are involved. Treatment with corticosteroids is controversial since it might aggravate the condition.

Cause

The cause of SJS is either infections (usually following viral infections such as herpes simplex virus, influenza, mumps, cat-scratch fever, histoplasmosis, Epstein-Barr virus, or similar), drug-induced (valdecoxib, penicillins, barbiturate, sulfas, phenytoin, lamotrigine, nevirapine), malignancy-related (carcinomas and lymphomas), or idiopathic (50% of the time)

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Erythema Multiforme: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.41 What's your assessment? (Clinical Skills). : An article from: Dermatology Nursing $5.95
Newly recognized infectious exanthems. : An article from: Dermatology Nursing $5.95 Bupropion-induced erythema multiforme : An article from: Mayo Clinic Proceedings $20.00
Gale Encyclopedia of Medicine : Erythema multiforme $1.50 Erythema multiforme associated with candesartan cilexetil.(Case Report) : An article from: Southern Medical Journal $5.95
On the visceral complications of erythema exudativum multiforme

Erythema multiforme
Erythema multiforme is a skin disease which causes lesions and redness around the lesions.
Thalidomide as elective treatment in persistent erythema multiforme; report of two cases
Abstract Recurrent erythema multiforme is a rare disorder, clinically characterized by symmetrically distributed, erythematous, and bullous skin and ...
Erythema multiforme - clinical manifestations, pathophysiology, etiology, differential diagnosis, treatment
Erythema multiforme is a cutaneous reaction pattern manifested by we,-demarcated plaques on the trunk and extremities. Target, or "iris," lesions, with ...
Erythema multiforme and Stevens-Johnson syndrome: descriptive and therapeutic controversy
Diagnosis and particularly the management of eryhthema multiforme and Stevens-Johnson syndrome are controversial in medical textbooks and thus in individual ...
Benzoic acid and erythema multiforme
BENZOIC ACID AND ERYTHEMA MULTIFORME Erythema multiforme is an acute inflammatory disorder characterized by a variety of lesions on the skin and the mucous ...
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Toxic epidermal necrolysis is a rare condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin ...
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