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Esgic

Fioricet and Esgic are brand name drugs made from a combination of acetaminophen (325 mg), butalbital (a barbiturate, 50 mg), and caffeine (40 mg). They are usually used to treat tension headaches and migraine headaches. more...

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Usage and Dosage

Fioricet is usually perscribed for difficult to treat tension headaches as well as migraine. The common dosing schedule is to take 1 - 2 tablets every 4 hours as needed, being careful not to exceed 12 tablets in 24 hours, both to avoid an overdose on the Butalbital and Caffeine, but also because an exceess of 4 grams of Acetaminophen per day causes a serious risk of liver damage.

This usage and dosing info is for informational purposes only and should not be used in place of the instructions of your doctor.

Side Effects

Side effects for any drug are difficult to predict, but commonly reported side effects for Fioricet include:

Abdominal pain
Dizziness
Drowsiness
Intoxicated feeling
Light-headedness
Nausea
Sedation
Addiction

There are other potential side-effects, this list should not be considered all-inclusive.

Dangers and Risks

Fioricet contains acetaminophen, which has been shown to cause Liver damage at higher dosages. Care should be excersized when using Fioricet to prevent possible liver damage. Fioricet also contains Butalbital, which is an addictive, mind (and behavior) altering barbituate. Fioricet can be habit forming. Fioricet should not be mixed with Alcohol, both due to the possibility of exacerbating liver damage in combination with the APAP, and due to increased risk of intoxication in combination with the Butalbital.

There are other potential risks, this list should not be considered all-inclusive.

Read more at Wikipedia.org

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Horizon Pharmaceutical Corporation Launches Tension Headche Product Zebutal
From Business Wire, 6/21/00

Business Editors

ROSWELL, Ga.--(BUSINESS WIRE)--February 8, 1999

Horizon Pharmaceutical Corporation, a privately held emerging pharmaceutical company, announced today that it has launched Zebutal(TM) capsules containing 500mg of acetaminophen, 50mg of butalbital and 40mg of caffeine in the U.S. and Puerto Rico for the treatment of tension headache. Zebutal(TM) is the only AB rated equivalent of Esgic- PlusTM capsules marketed by Forest Laboratories.

Horizon will focus its promotional efforts on primary care physicians, pharmacies and managed care organizations.

Horizon licensed Zebutal(TM) from West-ward Pharmaceutical Corporation in Eatontown, NJ and Atlantic Research and Development in Roswell, GA. Deliz Pharmaceutical Corporation will promote the product in Puerto Rico.

Tension-type headaches, affecting nearly 75% of all headache sufferers, occur most frequently in women 20-40 years of age. Left untreated or misdiagnosed, tension-type headaches may become a chronic problem, lead to depression, and result in frequent physician visits and loss of productivity for patients. Educational efforts to both the physician and patient regarding proper headache diagnosis and treatment options can significantly reduce unnecessary costs to the healthcare system.

"Zebutal(TM) capsule is an important entry into an under promoted market. Our research shows that physicians prefer products such as Zebutal(TM) that contain higher amounts of acetaminophen. Pharmacists now have the option of dispensing a value brand that is an AB rated equivalent to Forest's Esgic- Plus(TM) capsules," said Greg Hauck, Vice President of Marketing for Horizon Pharmaceuticals.

Horizon Pharmaceutical Corporation is a rapidly growing emerging pharmaceutical company focused on developing, marketing and selling differentiated prescription pharmaceuticals for the treatment of chronic diseases. Horizon currently markets eleven prescription products through its 75 person sales and marketing force. The company focuses on the respiratory, otic, gastrointestinal, pain and inflammation therapeutic markets. Horizon's strategy is to acquire and in-license differentiated, under-promoted, branded, chronic care products and increase sales through targeted promotion and marketing.

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