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Femara

Letrozole (Femara®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer. more...

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Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks this activity by competitive, reversible binding to the heme of its cytochrome p450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, Tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, does effect its antiestrogenic action by interfering with the estrogen receptor, not the estrogen production.

Letrozole is approved by the FDA for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis.

A related agent is anastrozole.

Read more at Wikipedia.org


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FDA advisory committee favors Femara approval for breast cancer - Brief Article
From Drug Store News, 1/15/01

The FDA's oncologic drugs advisory committee recommended approval of Femara (letrozole) tablets as first-line hormonal treatment for advanced breast cancer in postmenopausal women. Femara is a product of Novartis. Currently tamoxifen is standard therapy for this indication. In a clinical study reviewed by the committee, Femara was found to be significantly more effective than tamoxifen. The once daily treatment is currently indicated for treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.

COPYRIGHT 2001 Lebhar-Friedman, Inc.
COPYRIGHT 2001 Gale Group

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