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Fenfluramine

Fenfluramine is a drug that was part of the Fen-Phen anti-obesity medication (the other drug being phentermine). Also known as Pondimin, fenfluramine was introduced on the U.S. market in 1973. It is designed to increase the level of the neurotransmitter serotonin. This depresses the central nervous system, regulating mood and appetite. The end result is a feeling of fullness and loss of appetite.

The drug was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension.


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FDA warning on Chinese diet pills containing fenfluramine - Updates - Food and Drug Administration - Brief Article
From FDA Consumer, 9/1/02

The FDA is alerting the public about Chinese weight-loss products, Chaso (Jianfei) Diet Capsules and Chaso Genpi, because they pose a potential public health risk.

The agency is alerting the public to this health risk because several people in Japan have become ill, and some have died, after consuming these diet products.

"FDA is taking this action as a precautionary measure to help assure that people are not exposed to this potentially dangerous product," says FDA Deputy Commissioner Lester M. Crawford, D.V.M., Ph.D.

Products of this type are often sold in small urban markets as alternatives to Western medicine. In 2001, the FDA issued a nationwide alert on the recall of 13 "Treasure of the East" herbal products because of a dangerous ingredient, aristolochic acid, which is toxic to the kidney.

The deaths in Japan linked to these Chinese weight-loss products may have resulted from the presence of such active drug ingredients as fenfluramine in the capsules.

Fenfluramine and another diet drug, phentermine, were used in combination for weight loss until it was determined that the combination of drugs was linked to valvulopathy, a serious and sometimes fatal heart disease. Fenfluramine and a chemically similar drug, dexfenfluramine, were removed from the market in 1997. Phentermine, when used alone, has not been associated with valvulopathy and remains on the market.

The FDA has advised its import operations personnel to be on the alert for Chaso Diet Capsules and Chaso Genpi.

The agency is urging consumers not to take these diet pills and to notify their local FDA office if the products are found in their area.

COPYRIGHT 2002 U.S. Government Printing Office
COPYRIGHT 2004 Gale Group

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