Fluticasone chemical structure
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Flonase

Fluticasone proprionate is a glucocorticoid often prescribed as treatment for asthma and allergic rhinitis. It is marketed with the brand name Flixotide® and Flixonase® by Allen & Hanburys and Flovent® and Flonase® by GlaxoSmithKline. more...

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How it works

The precise mechanisms of glucocorticoid action in asthma are unknown. Inflammation is recognized as an important component in the pathogenesis of asthma. Glucocorticoids have been shown to inhibit multiple cell types (e.g., mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils) and mediator production or secretion (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in the asthmatic response. These anti-inflammatory actions of glucocorticoids may contribute to their efficacy in asthma. Typically, however, the action on the cells affected requires several days. Therefore, inhaled steroids are not used for immediate relief of asthma, but instead as preventive and maintenance therapy.

Clinical trials

This listing is NOT complete and should NOT be construed as support for treatment decisions. See also PubMed clinical manuscripts referring to fluticasone

  • Burge, P.S.; Calverley, P.M.; Jones, P.W.; Spencer, S.; Anderson, J.A.; and Maslen T.K. (2000). Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. British Medical Journal 320 (7245), 1297-1303. PMID 10807619.
  • Paggiaro, P.L.; Dahle, R.; Bakran, I.; Frith, L.; Hollingworth, K.; and Efthimiou, J. (1998). Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. The Lancet 351 (9105), 773-780. PMID 9519948.
both support a positive outcome for use of fluticasone in patients with chronic obstructive pulmonary disease, also referred to as COPD

Read more at Wikipedia.org


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Ragweed seasons - Flonase Allergy Alert Report - Brief Article
From Drug Store News, 9/13/00

The Flonase Allergy Alert Report ranked 25 cities among the worst for ragweed sufferers this season. These cities are expected to have the most severe ragweed pollen levels in the country from mid-August through the end of October.

Only the Northwest is expected to be relatively free of ragweed pollen this fall. It is estimated that 100 million tons of ragweed pollen is produced each year in North America. In addition to the cities listed here, others making the top 25 include, Tulsa, Okla.; Wichita, Kan.; St. Louis; Kansas City and Springfield, Mo.; Louisville and Lexington, Ky.; Omaha, Neb.; Austin and Lubbock, Texas;, Nashville, Tenn.; Columbus and Dayton, Ohio; South Bend, Ind.; and Des Moines, Iowa.

Source: "Flonase Allergy Alert Report 2000," Glaxo Wellcome Inc.

COPYRIGHT 2000 Lebhar-Friedman, Inc.
COPYRIGHT 2000 Gale Group

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