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Fludrocortisone

Fludrocortisone acetate is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. It is used primarily to replace mineralocorticoids in various forms of adrenal insufficiency such as Addison's disease and congenital adrenal hypoplasia. It is occasionally used to treat orthostatic hypotension as well.

The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are 1/2 to 2 tablets a day. In this dose glucocorticoid effect is minimal.

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One week of low-dose steroids led to 10% drop in deaths due to septic shock, renal failure. (Hydrocortisone and Fludrocortisone). : An article from: Internal Medicine News $5.95 "Fludrocortisone role in central regulation of fluid balance" : final report NASA-Ames NCC 2-764 : period covered, 7/1/93-1/15/96 (SuDoc NAS 1.26:206754)

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