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Fosmidomycin

Fosmidomycin is an antibiotic that specific inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4).

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Briefly
From Milwaukee Journal Sentinel, The, 9/3/99

Florida land case: A federal appeals court has rejected a claim from a Florida developer for government compensation because of environmental restrictions on use of his land, handing property rights advocates a major defeat. The three-judge panel said that developer Lloyd A. Good Jr., who had wanted to fill in wetlands to build a housing complex in the Florida Keys, was not entitled to compensation even though the restrictions substantially reduced the value of his property.

Car theft rings: Two Philadelphia-based car theft rings that stretched across five states and stole thousands of cars worth $40 million have been shut down, federal authorities said Thursday. Forty-seven people were arrested Thursday morning in Philadelphia and New Jersey, from alleged gang leaders to copy shop employees who allegedly duplicated car titles.

Malaria treatment: Scientists have discovered a possible new drug for malaria, an antibiotic that seemed to cure mice by attacking the disease in a different manner than today's treatments. There's no way to know yet if the antibiotic, fosmidomycin, will help people with malaria, which kills up to 3 million people a year worldwide.

Copyright 1999
Provided by ProQuest Information and Learning Company. All rights Reserved.

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