Gemfibrozil is the generic name for an oral lipid lowering drug. It is most commonly sold as the brand name, Lopid. more...
- Increase activity of Peroxisome proliferator-activated receptor-alpha (PPARα), a receptor which is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation.
- Reduce triglyceride levels
- Reduce Very low density lipoprotein (VLDL) levels
- Modest reduction of Low density lipoprotein (LDL) levels
- Moderate increase in High density lipoprotein (HDL) levels
Nontherapeutic effects and toxicities
- GI distress
- Musculoskeletal pain
- Increased incidence of gallstones
- Hyperlipidemia (Type III): Gemfibrozil is the drug of choice for therapy.
- Hypertriglyceridemia (Type IV): Gemfibrozil, though not as effective as nicotinic acid, is better tolerated.
Contraindications and Precautions
- Gemfibrozil should not be given to these patients:
- Hepatic dysfunction
- Renal dysfunction
- Gemfibrozil should be used with caution in these higher risk categories:
- Biliary tract disease
- pregnant women
- obese patients
- Native Americans
- Anticoagulants. Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
- Lovastatin. Risk of myopathy when gemfibrozil is given to patients receiving lovastatin.
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