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Glibenclamide

Glibenclamide is a class of drug known as sulfonylureas. Sulfonylureas are used to treat Type II diabetes. The drug works by inhibiting ATP-ase dependent sodium channels in pancreatic beta cells. The inhibition causes an influx of calcium into the beta cell which stimulate insulin release.

The drug is contraindicated in pregnant women. It is also a major cause of drug induced hypoglycaemia.

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