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Hashimoto's thyroiditis

Hashimoto's thyroiditis, the most common form of thyroiditis, is an autoimmune disease where the body's own antibodies fight the cells of the thyroid. Also known as Hashimoto's disease, it is named after the Japanese physician, Hakaru Hashimoto (1881–1934) of the medical school at Kyushu University, who first described it to medicine in 1912. It is four times more common among women than men, and runs in families, with the HLADR5 gene most strongly implicated (conferring a relative risk of 3) in the UK. The genes implicated vary in different ethnic groups. more...

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In many cases, Hashimoto's thyroiditis usually results in hypothyroidism, although in its acute phase, it can cause a transient hyperthyroid state.

Physiologically, antibodies to thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterised by invasion of the thyroid tissue by leukocytes, chiefly T-lymphocytes.

Treatment is by daily thyroxine, with the sodium salt of thyroxine liothyronine given when the need to raise levels of circulating thyroxine is urgent.

Symptoms of Hashimoto's thyroiditis include symptoms of hypothyroidism and a goitre.

In European countries an atrophic form of autoimmune thyroiditis (Ord's thyroiditis) is more common than Hashimoto's thyroiditis.

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Patient Information — Hashimoto's Disease: What It Is and How It's Treated
From American Family Physician, 2/15/00

What is Hashimoto's disease?

Hashimoto's disease is a problem of the thyroid gland. The thyroid gland in your neck controls the way your body uses energy. When you have Hashimoto's disease, your thyroid gland doesn't work right.

What are the symptoms of Hashimoto's disease?

Many people with this problem have no symptoms. An ordinary blood test may just show a thyroid hormone imbalance. Because the thyroid gland may grow, you may have a feeling of fullness or tightness in your throat. You may have trouble swallowing food or liquids. You might have a swelling (a bump) in the front of your neck. Some people with Hashimoto's disease have symptoms such as tiredness, forgetfulness, depression, coarse dry skin, slow heartbeat, weight gain, constipation and intolerance to cold. A blood test can tell if your thyroid gland is underactive. Other blood tests can be done to look for Hashimoto's disease.

Who gets Hashimoto's disease?

Although Hashimoto's disease can affect people of all ages, it's most common in women in their 30s and 40s. If someone in your family has had thyroid disease, you may have an increased risk for Hashimoto's disease. No one is sure why people get Hashimoto's disease.

How is Hashimoto's disease treated?

Hashimoto's disease has no cure. However, your doctor can treat low thyroid function so you probably won't have any long-term effects.

Thyroid medicine can replace the hormone your thyroid gland usually makes. The amount of time you will need to take this medicine depends on the results of your blood tests. Thyroid hormone medicine causes no problems in most people.

Taking your thyroid medicine and having regular blood tests to see how your thyroid gland is working can help prevent symptoms like tiredness, weight gain and constipation.

Where can I get more information?

You can find out more about Hashimoto's disease from these organizations:

Thyroid Foundation of America, Inc.

350 Ruth Sleeper Hall, RSL 350

40 Parkman Street

Boston, MA 02114-2698

Telephone: 1-800-832-8321 or 1-617-726-8500

Web site: www.tsh.org

National Organization for Rare Disorders, Inc. (NORD)

P.O. Box 8923

New Fairfield, CT 06812-8923

Telephone: 1-800-999-6673 (voicemail only) or 1-203-746-6518

Web site: www.rarediseases.org

COPYRIGHT 2000 American Academy of Family Physicians
COPYRIGHT 2000 Gale Group

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