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Hereditary spastic paraplegia

Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. more...

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Symptoms

Though the primary feature of HSP is severe, progressive, lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness.

Diagnosis

Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers.

Treatment

There are no specific treatments to prevent, slow, or reverse HSP. Symptomatic treatments used for other forms of chronic paraplegia are sometimes helpful. Regular physical therapy is important for improving muscle strength and preserving range of motion.

Prognosis

The prognosis for individuals with HSP varies. Some cases are seriously disabling while others are less disabling and are compatible with a productive and full life. The majority of individuals with HSP have a normal life expectancy.

Research

The NINDS supports research on genetic disorders such as HSP. Genes that are responsible for several forms of HSP have already been identified, and many more will likely be identified in the future. Understanding how these genes cause HSP will lead to ways to prevent, treat, and cure HSP.

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Grossbier, Alexander G. "Alex"
From Milwaukee Journal Sentinel, The, 7/19/05

Grossbier, Alexander G. "Alex"

Born to Eternal Life July 17, 2005 at the age of 77 years. Beloved husband of Mary Ann (nee Korger). Loving father of Glenn (Debra), Susan (Tony Weinhold), Annette (Steve Lockwood) and Robin. Beloved brother of Peter (Florence) of Milwaukee, Paul (Mary) of Wisconsin Rapids, Sr. Marian of LaCrosse, Renie Lorbiecki of New Berlin, Helen (Orville Bornbach) of Stratford and Virginia (Charles Ponzcoch) of Stratford. Special grandfather of Glenn Jr., Vicki (Nyman), Gary and Christina Lockwood, Alexa, Olivia and Katrina Weinhold. Preceded in death by his parents, Edward and Anna (nee Dillinger) Grossbier, his brother Aloyisius and his sister, Theresa. Alex retired from the Falk Corporation after 30 years of dedicated service. He has touched many lives during his courageous battle with Hereditary Spastic Paraplegia. Visitation at the Funeral Home on Thursday, July 20 from 9:30 AM until the time of Service at 11:30 AM. Entombment Wisconsin Memorial Park. Memorials to Spastic Paraplegia Foundation, Inc. appreciated. Many thanks to the very caring staff of Horizon Home Care and Hospice. Sympathy Expressions & Directions www.beckerritter.com BECKER RITTER Michael Feerick Associate 14075 West North Ave. (262)782-5330

Copyright 2005 Journal Sentinel Inc. Note: This notice does not apply to those news items already copyrighted and received through wire services or other media
Provided by ProQuest Information and Learning Company. All rights Reserved.

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