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HIDS

Hyperimmunoglobinemia D with recurrent fever (commonly abbreviated as HIDS) is a syndrome originally described in 1984 by the internist (now Professor) Jos van der Meer at Leiden University Medical Centre. No more than 300 cases have been described worldwide. more...

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Features

HIDS is one of a number of periodic fever syndromes. It is characterised by attacks of fever, arthralgia, skin lesions, and diarrhea. Laboratory features include an acute phase response (elevated CRP and ESR) and markedly elevated IgD (and often IgA), although cases with normal IgD have been described.

Therapy

The recurring fevers are highly unpleasant for patients, but so far only the immunosuppressant etanercept (EnbrelĀ®) has been shown to be effective. Statin drugs might decrease the level of mevalonate and are presently being investigated.

Cause

Virtually all patients with the syndrome have mutations in the gene for mevalonate kinase, which is part of the HMG-CoA reductase pathway, an important cellular metabolic pathway. Indeed, similar fever attacks (but normal IgD) have been described in patients with mevalonic aciduria - an inborn error of metabolism now seen as a severe form of HIDS.

Pathophysiology

Is it not known how mevalonate kinase mutations cause the febrile episodes, although it is presumed that other products of the cholesterol biosynthesis pathyway, the prenylation chains (geranylgeraniol and farnesol) might play a role.

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Market trends
From Aftermarket Business, 1/1/05 by Christina A. Thompson

The automotive lighting industry had revenues totaling $1.66 billion in 2004, according to Frost & Sullivan's Analysis of the North American Automotive Lighting Technologies Markets.

High intensity discharge (HID) headlights, light-emitting diode (LED) rear combination lamps and third brake lights have improved revenues, due to higher price points and increased demand.

HID headlamps, used mostly in high-end vehicles, produce up to twice as much light as halogen lamps and provide a bluish-white cast. The Frost & Sullivan analyst reported a motorist using HID is able to see about 100 meters to the front of the vehicle, compared to less than 60 meters with standard halogen lighting. Perceived glare has been the greatest fight of HID headlamps.

One manufacturer said new "white-light" bulbs offer the same positive effects of OE-style HID systems, but without offensive glare. The new technology uses special filters that remove yellow rays within the lamps' projected color spectrum, producing a truer, whiter light.

But, HID lights have been an issue for the National Highway Transportation Safety Administration (NHTSA). In 2001, they received more than 5,000 complaints and concerns about perceived glare from HIDs, knock-offs and higher-mounted and supplemental front-mounted auxiliary lamps.

Now, replacement headlamps must comply with all applicable photometry requirements (and the same light source) as the OEM equipment, which is creating quite a stir in the industry. Companies like SEMA have filed a Petition for Reconsideration because NHTSA did not produce evidence that this rule would reduce traffic accidents, deaths or injuries (see our cover story for more on this issue).

LEDs are primarily used for third brake lights and trailer lighting. A few domestic vehicles use LEDs for rear combination lamps. They withstand road vibration and shock more effectively than bulbs, and have a life expectancy six times that of average incandescent bulbs. Due to low heat output and small size, bright-white LED lamps are in development for front lighting. The smaller size offers more flexibility for styling. Frost & Sullivan says these will enter the market in 2010 and could threaten the HID market. The analyst group estimates that LEDs will also enter the North American market as daytime running lights around 2007.

But like HIDs, LEDs have also run into problems with NHTSA, due to non-compliant products entering the U.S. with an uneven light pattern or less light output than required by law. These non-compliant LEDs have been commonly sold for commercial vehicle use and have put a black eye on the LED market.

Two other technologies--adaptive front lighting and night vision systems--will likely boost profits in the coming years. Adaptive front lighting (AFL) technology adapts to different driving conditions by either swiveling the headlamps or by using additional headlamps.

Night vision systems use infrared cameras to project images onto the lower part of the windshield.

COPYRIGHT 2005 Advanstar Communications, Inc.
COPYRIGHT 2005 Gale Group

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