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Hydatidiform mole

A hydatidiform mole (or mola hydatidiforma) is a disease of trophoblastic proliferation. It can mimic pregnancy, causes high human chorionic gonadotropin (HCG) levels and therefore gives false positive readings of pregnancy tests. more...

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Hydatidiform mole
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Causes

The cause is not completely understood. Potential causes may include defects in the egg, abnormalities within the uterus, or nutritional deficiencies. Women under 20 or over 40 years of age have a higher risk. Other risk factors include diets low in protein, folic acid, and carotene.

Diagnosis

  • vaginal discharge & bleeding
  • size of uterus bigger than expected for gestational age
  • hyperemesis
  • high beta-HCG levels

Symptoms

  • Vaginal bleeding in pregnancy during the first trimester
  • Nausea and vomiting, severe enough to require hospitalization in 10% of cases
  • An abnormal growth in the size of the uterus, for the stage of the pregnancy. There is excessive growth in approximately 1/2 of cases and smaller than expected growth in approximately 1/3 of cases
  • Symptoms of hyperthyroidism are seen. These include
    • Rapid heart rate
    • Restlessness, nervousness
    • Heat intolerance
    • Unexplained weight loss
    • Loose stools
    • Trembling hands
    • Skin warmer and more moist than usual
  • Symptoms similar to preeclampsia that occur in the 1st trimester or early in the 2nd trimester. (This is nearly diagnostic of a hydatidiform mole, because preeclampsia is extremely rare this early in normal pregnancies.)
    • High blood pressure
    • Swelling in feet, ankles, legs
    • Proteinuria

Types

hydatidiform mole can be of two types: complete or partial. A mole is characterized by a conceptus of hyperplastic trophoblastic tissue attached to the placenta.

  • Complete moles are diploid in nature and are purely paternal. Ninety percent are 46,XX, and 10% are 46,XY. This occurs when an empty ovum is fertilized by two sperms. This process is called androgenesis. There are no fetal parts. It carries risk of malignancy to choriocarcinoma.
  • Partial moles are triploid (69 XXX, 69 XXY) in nature. This results from fertilization of a haploid ovum and duplication of the paternal haploid chromosomes or from dispermy. Some cases are tetraploid. Fetal parts are often seen. It has no malignant potential.

Pathology

For the complete mole, the anatomical appearance is like a bunch of grapes. Its DNA is purely paternal in origin. Less than 1% cases progress to choriocarcinoma.

For the partial mole, some fetal parts are seen.

Treatment

Hydatidiform moles should be treated by evacuating the uterus by uterine suction or surgically as soon as possible after diagnosis. Patients are followed up until their serum human chorionic gonadotrophin (hCG) titre has fallen to an undetectable level. Invasive or metastatic moles often respond well to methotrexate.

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Hydatidiform mole
From Gale Encyclopedia of Medicine, 4/6/01 by Carol A. Turkington

Definition

A hydatidiform mole is a relatively rare condition in which tissue around a fertilized egg that normally would have developed into the placenta instead develops as an abnormal cluster of cells. (This is also called a molar pregnancy.) This grapelike mass forms inside of the uterus after fertilization instead of a normal embryo. A hydatidiform mole triggers a positive pregnancy test and in some cases can become cancerous.

Description

A hydatidiform mole ("hydatid" means "drop of water" and "mole" means "spot") occurs in about 1 out of every 1,500 (1/1,500) pregnancies in the United States. In some parts of Asia, however, the incidence may be as high as 1 in 200 (1/200). Molar pregnancies are most likely to occur in younger and older women (especially over age 45) than in those between ages 20-40. About 1-2% of the time a woman who has had a molar pregnancy will have a second one.

A molar pregnancy occurs when cells of the chorionic villi (tiny projections that attach the placenta to the lining of the uterus) don't develop correctly. Instead, they turn into watery clusters that can't support a growing baby. A partial molar pregnancy includes an abnormal embryo (a fertilized egg that has begun to grow) that does not survive. In a compete molar pregnancy there is a small cluster of clear blisters or pouches that don't contain an embryo.

If not removed, about 15% of moles can become cancerous. They burrow into the wall of the uterus and cause serious bleeding. Another 5% will develop into fast-growing cancers called choriocarcinomas. Some of these tumors spread very quickly outside the uterus in other parts of the body. Fortunately, cancer developing from these moles is rare and highly curable.

Causes & symptoms

The cause of hydatidiform mole is unclear; some experts believe it is caused by problems with the chromosomes (the structures inside cells that contain genetic information) in either the egg or sperm, or both. It may be associated with poor nutrition, or a problem with the ovaries or the uterus. A mole sometimes can develop from placental tissue that is left behind in the uterus after a miscarriage or childbirth.

Women with a hydatidiform mole will have a positive pregnancy test and often believe they have a normal pregnancy for the first three or four months. However, in these cases the uterus will grow abnormally fast. By the end of the third month, if not earlier, the woman will experience vaginal bleeding ranging from scant spotting to excessive bleeding. She may have hyperthyroidism (overproduction of thyroid hormones causing symptoms such as weight loss, increased appetite, and intolerance to heat). Sometimes, the grapelike cluster of cells itself will be shed with the blood during this time. Other symptoms may include severe nausea and vomiting and high blood pressure. As the pregnancy progresses, the fetus will not move and there will be no fetal heartbeat.

Diagnosis

The physician may not suspect a molar pregnancy until after the third month or later, when the absence of a fetal heartbeat together with bleeding and severe nausea and vomiting indicates something is amiss.

First, the physician will examine the woman's abdomen, feeling for any strange lumps or abnormalities in the uterus. A tubal pregnancy, which can be life threatening if not treated, will be ruled out. Then the physician will check the levels of human chorionic gonadotropin (hCG), a hormone that is normally produced by a placenta or a mole. Abnormally high levels of hCG together with the symptoms of vaginal bleeding, lack of fetal heartbeat, and an unusually large uterus all indicate a molar pregnancy. An ultrasound of the uterus to make sure there is no living fetus will confirm the diagnosis.

Treatment

It is extremely important to make sure that all of the mole is removed from the uterus, since it is possible that the tissue is potentially cancerous. Often, the tissue is naturally expelled by the fourth month of pregnancy. In some instances, the physician will give the woman a drug called oxytocin to trigger the release of the mole that is not spontaneously aborted.

If this does not happen, however, a vacuum aspiration can be performed to remove the mole. In a procedure similar to a dilatation and curettage (D & C), a woman is given an anesthetic (to deaden feeling during the procedure), her cervix (the structure at the bottom of the uterus) is dilated and the contents of the uterus is gently suctioned out. After the mole has been mostly removed, gentle scraping of the uterus lining is usually performed.

If the woman is older and does not want any more children, the uterus can be surgically removed (hysterectomy) instead of a vacuum aspiration because of the higher risk of cancerous moles in this age group.

Because of the cancer risk, the physician will continue to monitor the patient for at least two months after the end of a molar pregnancy. Since invasive disease is usually signaled by high levels of hCG that don't go down after the pregnancy has ended, the woman's hCG levels will be checked every two weeks. If the levels don't return to normal by that time, the mole may have become cancerous.

If the hCG level is normal, the woman's hCG will be tested each month for six months, and then every two months for a year.

If the mole has become cancerous, treatment includes removal of the cancerous issue and chemotherapy. If the cancer has spread to other parts of the body, radiation will be added. Specific treatment depends on how advanced the cancer is.

Women should make sure not to become pregnant within a year after hCG levels have returned to normal. If a woman were to become pregnant sooner than that, it would be difficult to tell whether the resulting high levels of hCG were caused by the pregnancy or a cancer from the mole.

Prognosis

A woman with a molar pregnancy often goes through the same emotions and sense of loss as does a woman who has a miscarriage. Most of the time, she truly believed she was pregnant and now has suffered a loss of the baby she thought she was carrying. In addition, there is the added worry that the tissue left behind could become cancerous.

In the unlikely case that the mole is cancerous the cure rate is almost 100%. As long as the uterus was not removed, it would still be possible to have a child at a later time.

Key Terms

Dilatation and curettage (D & C)
Dilating the cervix and scraping the lining of the uterus with an instrument called a curette.
Placenta
The circular, flat organ that connects the fetus via the umbilical cord to the uterus for oxygen, food, and elimination of wastes.

Further Reading

For Your Information

    Books

  • Carlson, Karen J., Stephanie A. Eisenstat, and Terra Ziporyn. The Harvard Guide to Women's Health. Cambridge, MA: Harvard University Press, 1996.
  • Ryan, Kenneth J., Ross S. Berkowitz, and Robert L. Barbieri. Kistner's Gynecology, 6th ed. St. Louis: Mosby, 1995.

Gale Encyclopedia of Medicine. Gale Research, 1999.

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