Scopolamine chemical structure
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Hyoscine

Scopolamine, also known as hyoscine, is a tropane alkaloid drug obtained from plants of the Solanaceae family (Nightshade), such as henbane or jimson weed (Datura stramonium). It is part of the secondary metabolites of plants. more...

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It is structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors; it is thus classified as an anticholinergic.

In medicine, it is usually used in the form scopolamine hydrobromide. It can be used as a depressant of the central nervous system, though it can cause delirium in the presence of pain, mydriasis (pupillary dilation), and cycloplegia (paralysis of the eye muscles). When combined with morphine, it produces a tranquilized state known as twilight sleep and amnesia. Although originally used in obstetrics it is now considered dangerous.

It is used in ophthalmology to deliberately cause cycloplegia and mydriasis so that certain diagnostic procedures may be performed. It is also used in the treatment of iridocyclitis.

In otolaryngology it has been used to ease the trauma of intubation.

It is also an antiemetic (prevents vomiting), antivertigo (prevents dizziness), and antispasmodic (reduces smooth muscle contractions; although a derivate called butylscopolamine, that does not cross the BBB, is used preferably). It can be used as a pre-anesthetic sedation, as an antiarrhythmic (preventing irregular heartbeat) during anesthesia, and for the prevention of motion sickness.

The drug is highly toxic and has to be used in minute doses. An overdose can cause delirium, delusions, paralysis, stupor and death.

The use of scopolamine as a truth drug was investigated by various intelligence agencies, including the CIA, during the 50s. see:Project MKULTRA. It was found that, due to the hallucinogenic side effects of the drug, the truth was prone to distortion, and the project was subsequently abandoned.

Scopolamine is used criminally as a date rape drug and as an aid to robbery, the most common act being the clandestine drugging of a victim's drink. It is preferred because it induces retrograde amnesia, or an inability to recall events prior to its administration. Victims of this crime are often admitted to a hospital in police custody, under the assumption that the patient is experiencing a psychotic episode. A telltale sign is a fever accompanied by a lack of sweat.

In Colombia a plant admixture containing scopolamine called Burundanga has been used shamanically for decades. In recent years its criminal use (as outlined above) has become an epidemic. Approximately fifty percent of emergency room admissions for poisoning in Bogotá have been attributed to scopolamine.

Due to its effectiveness against sea-sickness it has become commonly used by scuba divers. However, this has lead to the discovery of another side effect. In deep water, below 50-60 feet, some divers have reported pain in the eyes, but the pain subsides quickly if the diver ascends to a depth of 40 feet or less. No study has been reported regarding the drug's effect on intra-ocular pressure or its effect on the eye's ability to adjust to pressure, so the medication should be used with extra caution among divers who intend to go below 50 feet.

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Criminal Poisoning: Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys. . - book review
From FBI Law Enforcement Bulletin,The, 4/1/02 by Rebecca A. Jufer

Criminal Poisoning: Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys by John Harris Trestrail III, Humana Press, Totowa, New Jersey, 2000.

Criminal poisoning is an offense that often receives little attention due to its apparently rare occurrence. Although statistics indicate that poisonings account for only 3 to 6 percent of homicides, many cases of criminal poisoning may go undetected as a result of the difficulties associated with detecting this type of crime. As noted by the author of the book, Criminal Poisoning, this type of crime frequently becomes known only after exhumation of the victim's remains. If this is the case, then how many additional poisoning cases are missed in the initial investigation process? In Criminal Poisoning, John Trestrail III provides investigators with a multidisciplinary guide for the investigation of criminal poisoning. To highlight some of the author's relevant experience, Trestrail has served as the managing director at a certified regional poison control center for over 20 years in addition to his work as an expert consultant in many criminal poisoning investigations. He also has presented numerous seminars on "Murder by Poison!" and "Poisoners Through History" and is a visiting instructor at the FBI Academy.

The author begins the book with a review of the historical use of poisons in ancient cultures, including the Sumerians, the Egyptians, the Greeks, and the Romans, among others. He also discusses poisoners in the modern era, including the cases of Dr. Crippen (hyoscine) and Henri Girard (various biological agents), as well as the murders of Georgi Markov (ricin) and Stella Nickell (cyanide). The cases reviewed prove very interesting, and the author provides a list of suggested readings at the end of each chapter.

The remainder of the book focuses on the practical investigation of poisoning cases, including types of poisons encountered, classification of poisoners, poisoning victim characteristics, crime scene investigation, the forensic autopsy, and the prosecution of poisoners. In this portion of the book, the author shares much of his own experience in the investigation of criminal poisonings. His survey of actual poisoning cases indicate that the most widely employed poisons are arsenic, cyanide, and strychnine. He discusses his own classification system for poisoners, which categorizes offenders according to victim specificity and the extent of planning completed for the poisoning event. In the chapter on crime scene investigation, he includes a detailed list of information to obtain during a poisoning investigation.

While not a comprehensive reference, Criminal Poisoning is a useful starting point for those involved in criminal poisoning investigations. Readers desiring more detailed information should consult reference materials on their topic of interest. With this consideration, the author has compiled an extensive bibliography, including references on poisoners throughout history, poisoning in fiction, forensic poisoning, and analytic toxicology. This bibliography is an extremely useful tool for the investigator pursuing difficult to find reference information, as it lists many resources not likely found in the most widely used medical reference databases.

The author concludes that investigators should consider poisoning in all death investigations that have no visible signs of trauma until the facts prove otherwise. A useful tool for the investigator, Criminal Poisoning discusses the aspects of poisoning cases in an easily followed style and provides investigators with basic, but important, information for the investigation of criminal poisoning cases.

COPYRIGHT 2002 Federal Bureau of Investigation
COPYRIGHT 2002 Gale Group

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