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Hypertension

Hypertension or high blood pressure is a medical condition where the blood pressure is chronically elevated. While it is formally called arterial hypertension, the word "hypertension" without a qualifier usually refers to arterial hypertension. more...

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Persistent hypertension is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure.

Definition

Blood pressure is a continuous variable, and risks of various adverse outcomes rise with it. A blood pressure of less than 120/80 mmHg is defined as "normal" in adults. Hypertension is usually diagnosed on finding blood pressure of 140/90 mmHg or above, measured on both arms on three occasions over a few weeks.

Recently, the JNC VII (The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) has defined blood pressure 120/80 mmHg to 140/90 mmHg as "prehypertension". Prehypertension is not a disease category. Rather, it is a designation chosen to identify individuals at high risk of developing hypertension (JNC VII).

In patients with diabetes mellitus or kidney disease studies have shown that blood pressure over 130/80 mmHg should be considered a risk factor and may warrant treatment.

Etiology

Essential hypertension

  • Age. Over time, the number of collagen fibres in artery and arteriole walls increases, making blood vessels stiffer. With the reduced elasticity comes a smaller cross-sectional area in systole, and so a raised mean arterial blood pressure.
  • High salt intake
  • Sedentary lifestyle
  • Tobacco smoking
  • Alcohol abuse
  • High levels of saturated fat in the diet
  • Obesity. In obese subjects, losing a kilogram of mass generally reduces blood pressure by 2 mmHg.
  • Stress
  • Low birth-weight
  • Diabetes mellitus
  • Various genetic causes

Secondary hypertension

While most forms of hypertension have no known underlying cause (and are thus known as "essential hypertension" or "primary hypertension"), in about 5% of the cases, there is a known cause, and thus the hypertension is secondary hypertension.

Pathophysiology

The mechanisms behind the factors associated with inessential hypertension are generally fully understood, and are outlined at secondary hypertension. However, those associated with essential hypertension are far less understood. What is known is that cardiac output is raised early in the disease course, with total peripheral resistance normal; over time cardiac output drops to normal levels but TPR is increased. Three theories have been proposed to explain this:

  • Inability of the kidneys to excrete sodium, resulting in natriuretic factor (note: the existence of this substance is theoretical) being secreted to promote salt excretion with the side-effect of raising total peripheral resistance.
  • An overactive renin / angiotension system leads to vasoconstriction and retention of sodium and water. The increase in blood volume leads to hypertension.
  • An overactive sympathetic nervous system, leading to increased stress responses.

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Pulmonary hypertension in patients with idiopathic pulmonary fibrosis
From CHEST, 10/1/05 by Hassan F. Nadrous

Study objectives: To determine the impact on survival and clinical correlates of pulmonary hypertension (PH) occurring in patients with idiopathic pulmonary fibrosis (IPF).

Design: Retrospective study.

Setting: Tertiary care, referral medical center.

Patients: Among 487 consecutive patients with IPF, we identified 136 patients who underwent transthoracic echocardiography within 3 months of their initial evaluation at our institution. Patients with left ventricular dysfunction, valvular heart disease, incomplete follow-up, and those in whom pulmonary artery pressures could not be assessed were excluded; the remaining 88 patients were included in this study. Correlations were performed between echocardiographic measures of PH and clinical variables including survival.

Measurements and results: The mean ([+ or -] SD) estimated systolic pulmonary artery pressure (SPAP) for the 88 patients was 48 [+ or -] 16 mm Hg (range, 28 to 116 mm Hg). Among pulmonary function parameters, SPAP correlated best with diffusing capacity of the lung for carbon monoxide (DLCO), to which it was inversely related. For survival analysis, patients were stratified into three groups: [less than or equal to] 35 mm Hg (14 patients), 36 to 50 mm Hg (47 patients), and > 50 mm Hg (27 patients). Using the Kaplan-Meier method, the median survival rates for these three groups were 4.8 years, 4.1 years, and 0.7 years, respectively. Those patients with SPAP > 50 mm Hg had significantly worse survival compared to other subgroups (p = 0.009).

Conclusion: In patients with IPF, PH correlates inversely with DLCO and has a significant adverse impact on survival, particularly when SPAP is > 50 mm Hg.

Key words: echocardiography; idiopathic pulmonary fibrosis; prognosis; pulmonary hypertension

Abbreviations: CI = confidence interval; DLCO = diffusing capacity of the lung for carbon monoxide; IPF = idiopathic pulmonary fibrosis; NYHA = New York Heart Association; PH = pulmonary hypertension; RR = relative risk; SPAP = systolic pulmonary artery pressure

**********

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive parenchymal lung disease of unknown cause with an underlying histopathologic pattern of usual interstitial pneumonia. (1-4) To our knowledge, no effective medical treatment exists for this disorder. (1-4) The overall prognosis is poor, with a median survival of < 3 years. (1,2,5,6)

Although IPF is associated with a poor prognosis, there is survival heterogeneity that is difficult to predict for individual patients. (1,2,5,6) Multiple studies (6-12) have attempted to identify clinical and physiologic predictors of survival and have yielded variable and sometimes contradictory results. Although the occurrence of pulmonary hypertension (PH) in patients with IPF is recognized, the clinical implications of this association have not been clear. (13,14) Additionally, revisions to the diagnostic criteria for IPF (2) warrant a reexploration of this issue. In the present report, we sought to determine the impact on survival and clinical correlates of PH occurring in patients with IPF.

MATERIALS AND METHODS

Study Population

This study was approved by the Mayo Foundation institutional review board. Using a computer-assisted search, 487 patients with IPF evaluated at Mayo Clinic Rochester during the period of January 1, 1994, to December 31, 1996, were identified. (15) The clinical, radiologic, and physiologic features for this population have been published previously. (15) Of these 487 patients, 136 patients (28%) underwent a comprehensive echocardiographic evaluation within 3 months of their initial visit at our medical center (index visit), and the study was available for current review. From this group of 136 patients, 48 patients were excluded for the following reasons: systolic pulmonary artery pressure (SPAP) not obtainable (25 patients), left ventricular ejection fraction < 40% (17 patients), valvular heart disease (3 patients), and incomplete follow-up (3 patients). The median survival of patients in whom SPAP was unobtainable was 2.3 years; the median survival of patients with left ventricular ejection fraction < 40% was 1.4 years. The remaining 88 patients were included in this study. The mean ([+ or -] SD) interval betweenechocardiography and the index visit was 3.3 [+ or -] 8.2 days.

All 88 patients included in this study manifested characteristic clinical features of IPF plus either typical high-resolution CT findings (n = 71) and/or histopathologic evidence on surgical lung biopsy specimen for usual interstitial pneumonia (n = 17) as described in the American Thoracic Society/European Respiratory Society consensus definition for IPF. (2) The medical records were carefully reviewed to exclude known causes of PH, including prior venous thromboembolism, HIV infection, systemic vasculitis or other connective tissue diseases, chronic liver disease with portal hypertension, left ventricular dysfunction, and history of anorexigenic drugs.

Clinical Data Collection

The clinical data, laboratory results, pulmonary function data, high-resolution CT results, and bronchoscopy and lung biopsy results from the initial evaluation at our medical center were extracted from the medical records. Treatments for IPF prior to and after the index visit date, including oxygen therapy, were also recorded. We determined the vital status of patients by reviewing medical records and death certificates as well as by telephone interviews.

Pulmonary function testing was performed using daily calibrated equipment (models 1070 and 1085; Medical Graphics; St. Paul, MN) according to American Thoracic Society specifications as previously described. (15) The pulmonary function tests included lung volumes with total lung capacity, spirometry including FVC and [FEV.sub.1], diffusion capacity of the lung for carbon monoxide (DLCO), oxygen saturation at rest and with exercise, and arterial blood gas analysis at rest and with exercise. Baseline pulmonary function testing was defined as the test performed at our medical center closest to the index visit, limited to tests within 90 prior or 14 days following the index visit date.

Transthoracic Echocardiography: Doppler and Color Flow Imaging

Two-dimensional transthoracic echocardiography, pulsed and continuous-wave Doppler, and color flow imaging were performed in all patients using previously described techniques. (16,17) The echocardiographic studies were reviewed by two cardiologists (N.C., P.A.P.) who were unaware of the clinical data. Pulmonary arterial hypertension was defined as a SPAP > 35 mm Hg at rest. SPAP was calculated based on the modified Bernoulli equation, and right atrial pressure was estimated as 5, 10, 15, or 20 mm Hg, on the basis of the size and respiratory change of the inferior vena cava using previously described techniques. (18,19) Right atrial and ventricular size along with right ventricular hypertrophy and systolic function were scored semiquantitatively on a scale of 0 (normal), 1 (mildly impaired or enlarged), 2 (moderately impaired or enlarged), or 3 (severely impaired or enlarged). Left ventricular dimensions, ejection fraction, and cardiac index were obtained by previously recommended techniques." (20)

Statistical Analysis

Baseline characteristics were compared across the three SPAP subgroups ([less than or equal to] 35 mm Hg, 36 to 50 mm Hg, and > 50 mm Hg) using an exact test for discrete variables and the Kruskal-Wallis test for continuous variables. A Spearman correlation coefficient was used to examine the association of SPAP with pulmonary function parameters and echocardiographic test results. For survival analysis, time zero is defined as the index visit, which was the date the patient was first seen at our medical center during the original study period (January 1, 1994, to December 31, 1996). Cumulative survival probabilities were estimated using the Kaplan-Meier method. (21) Cox proportional hazards regression was used to identify variables associated with survival. 22) Potential predictors considered in the survival analysis included age at index visit, gender, smoking status (current or former vs never), New York Heart Association (NYHA) functional status, history of coronary artery disease, history of congestive heart failure, history of hypertension or a history of diabetes mellitus, digital clubbing, treatment (any vs none), oxygen use prior to index visit, SPAP, estimated cardiac output, estimated cardiac index, estimated right atrial pressure, percentage of predicted FVC, percentage of predicted DLCO, and percentage of predicted [FEV.sub.1] Oxygen saturation at rest and exercise as well as Pa[O.sub.2], PaC[O.sub.2], and alveolar-arterial oxygen gradient at rest were not used in the survival analysis because these measures were not consistently obtained. In all eases, p < 0.05 was considered statistically significant.

RESULTS

Clinical Characteristics of IPF Patients With PH

The clinical characteristics of the 88 patients are summarized in Table 1. The mean estimated SPAP for the entire group was 48 [+ or -] 16 mm Hg (range, 28 to 116 mm Hg). Evidence of PH (SPAP > 35 mm Hg at rest) was present in 74 patients (84%). Patients were stratified by SPAP into three subgroups: [less than or equal to] 35 mm Hg, 36 to 50 mm Hg, and > 50 mm Hg, and included 14 patients (16%), 47 patients (53%), and 27 patients (31%), respectively. The three groups were similar except for gender, NYHA functional status, history of congestive heart failure, and oxygen use prior to index visit. Patients with SPAP > 50 mm Hg were more likely to be men, have a worse NYHA functional status and a history of congestive heart failure, and receive supplemental oxygen.

Echocardiographic Findings

The echocardiographic findings of the 88 patients with IPF are summarized in Table 2. Right atrial and right ventricular enlargement were found in 20 patients (23%) and 18 patients (20%), respectively. Right ventricular systolic function was impaired in 10 patients (11%). On the basis of color flow imaging, tricuspid regurgitation was present in 56 patients (64%). Continuous-wave Doppler study was satisfactory for evaluation of SPAP in all 88 patients. The median peak velocity of tricuspid regurgitation was 2.9 [- or -] 0.6 m/s (range, 2.0 to 4.9 m/s). Twenty-seven patients (31%) had an estimated SPAP > 50 mm Hg. Among 14 patients who had an estimated SPAP [less than or equal to] 35 mm Hg, none had right atrial or right ventricular enlargement or an impaired right ventricular function. Of 10 patients with an impaired right ventricular systolic function, 8 patients had an estimated SPAP > 60 mm Hg. The mean left ventricular ejection fraction was 60 [+ or -] 8% (range, 40 to 79%). Of 88 patients, 5 patients had minimal pericardial effusion without evidence of cardiac tamponade. Two patients had patent foramen ovale with trivial shunt.

Correlation of Pulmonary Function With Echocardiographic Measures of PH

All 88 patients had pulmonary function testing (Table 3). The patients with SPAP > 50 mm Hg had more impaired DLCO and Pa[O.sub.2], but no other significant differences were found among the three subgroups. There was an inverse correlation between DLCO and SPAP (r = -0.47, p < 0.001). There was also an inverse correlation between SPAP and Pa[O.sub.2] at rest (r = -0.36, p = 0.007) and oxygen saturation at rest (r = -0.33, p = 0.013), as well as a direct correlation with the alveolararterial oxygen tension gradient at rest (r = 0.29, p = 0.035). None of the remaining indexes of pulmonary function including FVC, [FEV.sub.1], and [FEV.sub.1]/FVC correlated with echocardiographic-derived SPAP.

Survival

The median and estimated 1-year and 3-year survival rates for the three subgroups are as follows: [less than or equal to] 35 mm Hg (median, 4.8 years; 1 year = 100%; 95% confidence interval [CI], 100 to 100%; 3 year = 64%; 95% CI, 44 to 95%); 36 to 50 mm Hg (median, 4.1 years; 1 year = 79%; 95% CI, 68 to 91%; 3 year = 61%; 95% CI, 49 to 77%); and > 50 mm Hg (median, 0.7 years; 1 year = 44%; 95% CI, 29 to 68%; 3 year = 32%; 95% CI, 19 to 57%) [Fig 1]. Increased SPAP was associated with shortened survival (relative risk [RR], 1.34 per 10 mm Hg increase; 95% CI, 1.17 to 1.53; p < 0.001). Univariate analysis for the entire cohort also demonstrated shorter survival to be associated with male gender (RR, 2.6; 95% CI, 1.37 to 4.95; p = 0.004), oxygen use prior to index visit (RR, 1.90; 95% CI, 1.02 to 3.51; p = 0.042), lower DLCO (RR, 1.61 per 10 percentage point decrease; 95% CI, 1.26 to 2.04; p < 0.001), history of coronary artery disease (RR, 1.96; 95% CI, 1.13 to 3.40; p = 0.017), and worse NYHA class (RR, 1.62; 95% CI, 1.17 to 1.53; p = 0.044).

[FIGURE 1 OMITTED]

DISCUSSION

This study describes echocardiographic characteristics and survival of patients with PH associated with IPF. Our data suggest that significant PH is not limited to patients with advanced IPF. SPAP correlated inversely with DLCO. The estimated survival from the time of IPF diagnosis of patients with SPAP > 50 mm Hg was substantially worse than that of patients with SPAP [less than or equal to] 50 mm Hg. PH is likely more common than currently suspected in patients with IPF and has prognostic and management implications. This subgroup of patients may warrant more aggressive management or early referral for lung transplantation.

Secondary PH is more common than primary PH, and there is a consensus that PH in patients with interstitial lung disease is associated with worse survival. However, little has been known about the association between PH and IPF. (23) Effective treatment of PH may prolong survival in patients who have IPF and PH. The major obstacle in treating PH has been the limited availability of oral or IV drugs that affect the pulmonary vasculature without causing excessive systemic vasodilation or increasing ventilation-perfusion mismatching. (23,24) With the increasing availability of drugs for the treatment of PH such as bosentan, (25) sitaxsentany, (27) treprostinil, (28) iloprost, (29) beraprost, (30) sildenafilal, (32) in addition to epoprostenol, (33) it may be reasonable to explore their role further in treating PH associated with IPF.

It has been difficult to accurately predict the clinical course in individual patients with IPF. (1,2) Published studies (6-9,19,34) have identified several demographic (age, sex, smoking), physiologic (DLCO, FVC), radiologic, and histopathologic features (eg, fibroblastic loci), and combinations of these parameters that correlate with survival. However, conclusions from these studies (6-9,19,34) have not been entirely consistent. Other studies have examined the association between survival of patients with IPF and the trends in pulmonary function over time. Flaherty et al (11) found a decrease of > 10% in FVC over a 6-month follow-up period to be an independent risk factor for mortality. Collard et al (10) showed that changes in clinical as well as physiologic variables over 6-month and 12-month periods are predictive of survival and provide more accurate prognostic information than baseline values alone. Latsi et al (12) also showed that serial pulmonary function trends have considerable prognostic value, not only for patients with IPF but also in patients with fibrotie nonspecific interstitial pneumonia.

The prevalence and prognostic significance of PH in patients with IPF as well as the impact of therapy for PH on these patients needs to be explored further. Harari et al (13) examined the prognostic value of PH in patients with chronic interstitial lung disease referred for lung transplantation including 43 patients with "IPF" and found that neither hemodynamic nor respiratory parameters obtained during the preoperative clinical screening predicted survival. In addition, there was no correlation between pulmonary function parameters and PH in these patients. However, the mean survival of these patients with advanced lung disease in their study was short (5.67 [+ or -] 0.42 months), making the detection of any impact of PH on survival difficult. In contrast, Jezek (14) noted PH to have a significant impact on survival of patients with "idiopathic diffuse interstitial lung fibrosis."

An important limitation of this study is its retrospective design and the lack of right-heart catheterization to confirm the presence and degree of PH. These patients underwent echocardiography for a variety of reasons, and potential biases exist based on this selection process. In addition, there are recognized limitations to the use of echocardiography in evaluating PH in patients with advanced lung disease. (35,36) Care must be taken to align the Doppler beam with the direction of flow or underestimation of the pulmonary artery pressure may result. Even if there is insufficient tricuspid regurgitation to allow measurement of pulmonary artery pressure, it cannot be assumed that the pulmonary artery pressure is normal. With these caveats, Doppler echocardiography is a convenient, noninvasive, and relatively accurate tool for evaluating PH. (16,17,37,38) A recent study (39) suggests that plasma level of brain natriuretic peptide may be a predictor of moderate to severe PH in patients with pulmonary fibrosis. Interestingly, lung function parameters did not correlate with brain natriuretic peptide level or the presence of PH. Plasma brain natriuretic peptide level and echocardiography may have complementary roles in the evaluation of patients with IPF.

CONCLUSIONS

Our data demonstrate that SPAP correlates inversely with DLCO and PH has a significant adverse impact on survival, particularly when SPAP is > 50 mm Hg. Further studies are needed to define the prevalence of PH as well as management implications for patients with IPF.

Manuscript received December 14, 2004; revision accepted February 17, 2005.

REFERENCES

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(3) Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med 2001; 345:517-525

(4) American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002; 165:277-304

(5) Bjoraker JA, Ryu JH, Edwin MK, et al. Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 157:199-203

(6) King TE Jr, Tooze JA, Schwarz MI, et al. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001; 164:1171-1181

(7) Schwartz DA, Helmers RA, Galvin JR, et al. Determinants of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1994; 149:450-454

(8) Erbes R, Schaberg T, Loddenkemper R. Lung function tests in patients with idiopathic pulmonary fibrosis: are they helpful in predicting outcome? Chest 1997; 111:51-57

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(10) Collard HR, King TE Jr, Bartelson BB, et al. Changes in clinical and physiologic variables predict survival in idiopathic and pulmonary fibrosis. Am J Respir Crit Care Med 2003; 168:538-542

(11) Flaherty KR, Mumford JA, Murray S, et al. Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia. Am J Respir Crit Care Med 2003; 168:543-548

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(24) Shapiro S. Management of pulmonary hypertension resulting from interstitial lung disease. Curr Opin Pulm Med 2003; 9:426-430

(25) Rubin LJ, Badesch DB, Barst RJ, et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346: 896-903

(26) Barst RJ, Langleben D, Frost A, et al, and the STRIDE-1 Study Group. Sitaxsentan therapy for pulmonary arterial hypertension. Am J Respir Crit Care Med 2004; 169:441-447

(27) Barst RJ, Rich S, Widlitz A, et al. Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest 2002; 121:1860-1868

(28) Simonneau G, Barst RJ, Galie N, et al, and the Treprostinil Study Group. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care M 2002; 165:800-804

(29) Hoeper MM, Schwarze M, Ehlerding S, et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 2000; 342:1866-1870

(30) Galie N, Humbert M, Vachiery JL, et al, and the Arterial pulmonary Hypertension and Beraprost European (ALPHABET) Study Group. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 2002; 39:1496-1502

(31) Wilkens H, Guth A, Konig J, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001; 104:1218-1222

(32) Michelakis E, Tymchak W, Lien D, et al. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 2002; 105:2398-2403

(33) Badesch DB, Tapson VF, McGoon MD, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: a randomized, controlled trial. Ann Intern Med 2000; 132:425-434

(34) Nicholson AG, Fulford LG, Colby TV, et al. The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2002; 166:173-177

(35) Arcasoy SM, Christie JD, Ferrari VA, et al. Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med 2003; 167:735-740

(36) Homma A, Anzueto A, Peters JI. Pulmonary artery systolic pressures estimated by echocardiogram vs cardiac catheterization in patients awaiting lung transplantation. J Heart Lung Transplant 2001; 20:833-839

(37) Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004; 350:886-895

(38) McGoon M, Gutterman D, Steen V, et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004; 126:14S-34S.

(39) Leuchte HH, Neurohr C, Baumgartner R, et al. Brain natriuretic peptide and exercise capacity in lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 2004; 170:360-365

Hassan F. Nadrous, MD; Patricia A. Pellikka, MD; Michael J. Krowka, MD; Karen L. Swanson, DO; Nithima Chaowalit, MD; Paul A. Decker, MS; and Jay H. Ryu, MD, FCCP

* From the Division of Pulmonary, Critical Care, and Internal Medicine (Drs. Nadrous and Ryu), Division of Cardiovascular Diseases (Drs. Chaowalit and Pellikka), Department of Health Sciences Research (Mr. Decker), and Pulmonary Hypertension Clinic (Drs. Krowka and Swanson), Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN.

Dr. Chaowalit was supported by Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Correspondence to: Jay H. Ryu, MD, FCCP, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: ryu.jay@mayo.edu

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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