Structural formula of isoflurane
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Isoflurane


Isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) is a halogenated ether used for inhalation anesthesia. Together with enflurane and halothane it replaced the flammable ethers used in the pioneer days of surgery. Its use in human medicine is now starting to decline, being replaced with sevoflurane, desflurane and the intravenous anaesthetic propofol. Isoflurane is still frequently used for veterinary anaesthesia. more...

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Isoflurane is always administered in conjunction with air and/or pure oxygen. Often nitrous oxide is also used. Although its physical properties means that anaesthesia can be induced more rapidly than with halothane, its pungency can irritate the respiratory system, negating this theoretical advantages conferred by its physical properties. It is usually used to maintain a state of general anesthesia that has been induced with another drug, such as thiopentone or propofol.

A major advantage of isoflurane is that it is no longer patented, and hence very economical to use.

It vaporizes readily, but is a liquid at room temperature. It is completely non-flammable.

Physical properties

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A Comparison of Halothane and Isoflurane on Cerebral Ischemic Thresholds as Assessed by EEG and Cortical Depolarisation $31.00 Gender Effect on Recovery Time Following Isoflurane Administration While Using a Bispectral Index Monitor $25.95
Liquid gastric emptying in the pig: Effect of concentration of inhaled isoflurane : An article from: The Journal of Nuclear Medicine $20.00

Changes in hemodynamics during isoflurane and propofol anesthesia: a comparison study
Objectives: Volatile anesthetics are thought to impair cerebral autoregulation more than i.v. anesthetics. However, few comparative studies have been carried out in humans. The aim of our study was t
Isoflurane therapy for status asthmaticus in children and adults
Two adults and two children with life-threatening asthma refractory to maximal standard therapy were treated with the inhalational anesthetic agent isoflurane. In each case, the temporal response t
Influence of isoflurane anesthesia on motor evoked potentials elicited by transcortical, brainstem, and spinal root stimulation
Electrical stimulation over the motor cortex, base of the skull, and cervical spine motor roots was performed in 9 male rats (410 86 g) before and after ...
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Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent
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Intravenous immunoglobulin ameliorates experimental autoimmune encephalomyelitis and reduces neuropathological abnormalities when administered prophylactically
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