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Korsakoff's syndrome

Korsakoff's syndrome (aka Korsakoff's psychosis, amnesic-confabulatory syndrome), is a continuum of Wernicke's encephalopathy, though a recognised episode of Wernicke's is not always obvious. Korsakoff's presents with symptoms of severe anterograde and retrograde amnesia, as well as confabulation. These symptoms are caused by damage to mammillary bodies and other brain regions due to deficiency of thiamine (Vitamin B1). This is most often caused by chronic alcoholism, though other conditions including severe malnutrition have been known to cause it. When Wernicke's encephalopathy accompanies Korsakoff's syndrome, the combined syndrome is called the Wernicke-Korsakoff syndrome. more...

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Pathologically, there is neuronal loss, gliosis, and hemorrhage in mammillary bodies. Damage to the dorsomedial nucleus of the thalamus is also associated with this disorder.

Intravenous (IV) or intramuscular (IM) injection of thiamine is used to treat this condition, though recovery is slow and often incomplete.

A famous case study is recounted by Oliver Sacks in "The Lost Mariner", which can be found in The Man Who Mistook His Wife for a Hat.

Read more at Wikipedia.org


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The Wernicke-Korsakoff syndrome;: A clinical and pathological study of 245 patients, 82 with post-mortem examinations (Contemporary neurology series) $25.00 Alcoholic Korsakoff's Syndrome: An Information Processing Approach to Amnesia $105.63
Le syndrome de Korsakoff $25.99 Gale Encyclopedia of Medicine : Korsakoff's syndrome $3.90
Effects of physostigmine on enhancing acetylcholine levels and on the spontaneous alternation in the normal and diencephalon-lesioned animals ([Honors ... State University of New York at Binghamton) The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition (Contemporary Neurology, No. 30) $55.00
Korsakoff-like amnesic syndrome in penetrating brain injury;: A study of Finnish war veterans (Acta neurologica Scandinavica. Supplementum)

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