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Lamisil

Terbinafine hydrochloride, sold as Lamisil tablets in the U.S., is often prescribed for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (Tinea unguium). more...

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It is also sold as a 1% cream or powder for use on suface infections such as jock itch (Tinea cruris) or athlete's foot (Tinea pedis).

Nail fungus infections live deep under the nail in the nail bed. Surface treatments may not be able to reach it in sufficient amounts, so terbinafine hydrochloride is given orally in tablet form, which is absorbed through the bloodstream to reach the infection; this method can cause hepatotoxicity, or liver damage, as well as other serious side effects, so those taking Lamisil tablets often have blood screenings every month. Many health insurance companies consider these infections to be a cosmetic problem, and either do not cover the cost of the months-long course of Lamisil, which can run into the thousands of dollars, or recommend use of less expensive alternatives like fluconazole.

The tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride, which is a white fine crystalline powder that is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Chemically, it is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1- naphthalenemethanamine hydrochloride. The empirical formula C21H26CIN with a molecular weight of 327.90

  • Active Ingredients: Terbinafine hydrochloride (equivalent to 250 mg base)
  • Inactive Ingredients: Colloidal silicon dioxide, Hydroxypropyl methylcellulose USP, Sodium starch glycolate, Magnesium stearate, Microcrystalline cellulose.

Read more at Wikipedia.org


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Rx for Lamisil is OTC - over the counter - Brief Article
From Drug Store News, 11/27/00

Footcare innovations have quickened the pace of category sales, bringing new success to drug chains that target active, time-pressed consumers, as well as aging boomers. Both are huge consumer groups who make many incremental purchases when in the store to relieve foot ailments.

Athlete's foot is one of the most common maladies, affecting more than 10 percent of Americans annually. And this year, the Rx-to-OTC switch of full-prescription-strength Lamisil AT instantly became a breakthrough treatment for millions of sufferers. Now they can treat their athlete's foot for one week--as opposed to four weeks for other OTC products--and remain free of the ailment even three months later. That's because it kills the fungi that causes the infection, rather than just inhibit its growth.

The success of Rx-to-OTC switches has been long-proven. Making Lamisil Rx cream, the most-prescribed medicine for athlete's foot, easily accessible to everyone excited a category that had been stagnant. Within just ten weeks at retail, sales of Lamisil AT Pump Spray, the OTC delivery form, surpassed the rate of annual prescription unit sales. Within four months, it became the No. 1 doctor-recommended brand for athlete's foot.

This impactful new product from Novartis Consumer Health earned the Drug Store News 2000 REX Award for Foot Care.

M.J. Weldon, director of marketing, dermatology group at Novartis, attributes much of the brand's success to "an extensive logistics/direct-store-delivery effort coupled with full retailer participation, broker force commitment and an outstanding effort by our field sales force. This helped us achieve our objective of full national ACV distribution of over 70 percent in less than seven days."

The company knew demand would be high because of a fully integrated marketing campaign that included television and print advertising, detailing to physicians and pharmacists, and extensive public relations.

The public and health professionals quickly understood the brand's benefits, creating a leap in category sales and profitability. Moreover, the trade increasingly sees Novartis as "a leader in nutritional and self-medication healthcare that understands and fulfills consumer needs, brings new technologies to market, supports its brands with national marketing and retailer-specific promotions," adds Marcia Weiner, associate director of trade business development.

In 2001, Lamisil AT will launch two new Odor Guard items in foot deodorizing and a new line of insoles under the Stride Guard brand name.

Elements of Excellence

* Science-based innovation

* Engaging support of physicians and pharmacists

* Fully integrated marketing campaign

* Superior logistics

* Consumer insights lead to meaningful new products

COPYRIGHT 2000 Lebhar-Friedman, Inc.
COPYRIGHT 2001 Gale Group

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