Levofloxacin is a fluoroquinolone antibiotic, marketed by Ortho-McNeil under the brand name Levaquin. Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin. more...
Levofloxacin is effective against a number of gram-positive and gram-negative bacteria. Because of its broad spectrum of action, levofloxacin is frequently prescribed empirically for a wide range of infections (e.g. pneumonia, urinary tract infection) before the specific causal organism is known. If the causal organism is identified, levofloxacin is sometimes discontinued and the patient may be switched to an antibiotic with a narrower spectrum
- Enterococcus faecalis (many strains are only moderately susceptible)
- Staphylococcus aureus (methicillin-susceptible strains)
- Staphylococcus epidermidis (methicillin-susceptible strains)
- Staphylococcus saprophyticus
- Streptococcus pneumoniae (including penicillin-resistant strains*)
- Streptococcus pyogenes
Levofloxacin only has moderate Gram-positive coverage; beta-lactams (e.g. ceftriaxone) or glycopeptides (e.g. vancomycin) are generally preferred for this indication.
- Enterobacter cloacae
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Escherichia coli
- Legionella pneumophila
- Serratia marcescens
- Haemophilus influenzae
- Moraxella catarrhalis
- Haemophilus parainfluenzae
- Proteus mirabilis
- Chlamydia pneumoniae
- Mycoplasma pneumoniae
Some information extracted from Levaquin Prescribing information.
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