Lidocaine chemical structure
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Lidocaine

Lidocaine (INN) or lignocaine (former BAN) is a popular local anesthetic that is often used in dentistry or topically. The most commonly encountered lidocaine preparations are marketed by AstraZeneca under the brand names Xylocaine and Xylocard, though lidocaine is also found in many other proprietary preparations. more...

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Its name was coined after the local anesthetic procaine, which in turn replaced cocaine as an anesthetic in dental practice.

History

Lidocaine, the first amide-type local anesthetic, was developed by Nils Löfgren and Bengt Lundqvist in 1943 and first marketed in 1948.

Also used in pet medications.

Pharmacology

Lidocaine is metabolized in the liver to pharmacologically active breakdown products which are excreted by the kidneys. It is faster acting and longer lasting than procaine (Novocain).

When given intravenously, lidocaine is a class Ib antiarrhythmic agent and will block the sodium channel of the cardiac action potential, which decreases automaticity by reducing the slope of phase 4 depolarization with little effect on the PR interval, QRS complex or QT interval.

This drug is used in the treatment of ventricular cardiac arrhythmias and cardiac arrest with ventricular fibrillation, especially with acute ischemia, though it is not useful in the treatment of atrial arrhythmias.

The elimination half life of intravenous lidocaine is about 109 minutes, but because it is metabolized in the liver (which depends on liver blood flow), dosage should be reduced in patients with low cardiac output or who are in shock. In patients with cardiogenic shock, the half life may exceed ten hours.

Toxicity

Toxicity is most often seen when there has been an inadvertent intravascular injection of lidocaine when being used as a local anesthetic. Central nervous system toxicity manifests as tinnitus, dizziness, paresthesia (pins and needles), confusion and – in more severe cases – seizures or coma. Severe toxicity may also result in cardiovascular system collapse or ventricular fibrillation.

Related Information

  • Benzocaine
  • Bupivacaine
  • Procaine
  • Cocaine


Read more at Wikipedia.org


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Skin permeation device improves the clinical utility of topical lidocaine
From Critical Care Nurse, 2/1/05

SONTRA MEDICAL CORP HAS RECEIVED FDA CLEARANCE TO MARKET the SonoPrep skin permeation device and procedure tray for use with topical lidocaine. The SonoPrep device applies low-frequency ultrasound to a patient's skin for approximately 15 seconds to create imperceptible, reversible microchannels through the stratum corneum (outermost layer of the skin), making the skin permeable so that the onset of action for transdermal drugs is accelerated. Clinical data demonstrate that rapid skin anesthesia with 4% lidocaine was achieved within 5 minutes following a skin pretreatment with SonoPrep, compared to other products that may require up to 60 minutes.

For more information, visit www.sontra.com.

COPYRIGHT 2005 American Association of Critical-Care Nurses
COPYRIGHT 2005 Gale Group

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