Lidocaine chemical structure
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Lidocaine

Lidocaine (INN) or lignocaine (former BAN) is a popular local anesthetic that is often used in dentistry or topically. The most commonly encountered lidocaine preparations are marketed by AstraZeneca under the brand names Xylocaine and Xylocard, though lidocaine is also found in many other proprietary preparations. more...

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Its name was coined after the local anesthetic procaine, which in turn replaced cocaine as an anesthetic in dental practice.

History

Lidocaine, the first amide-type local anesthetic, was developed by Nils Löfgren and Bengt Lundqvist in 1943 and first marketed in 1948.

Also used in pet medications.

Pharmacology

Lidocaine is metabolized in the liver to pharmacologically active breakdown products which are excreted by the kidneys. It is faster acting and longer lasting than procaine (Novocain).

When given intravenously, lidocaine is a class Ib antiarrhythmic agent and will block the sodium channel of the cardiac action potential, which decreases automaticity by reducing the slope of phase 4 depolarization with little effect on the PR interval, QRS complex or QT interval.

This drug is used in the treatment of ventricular cardiac arrhythmias and cardiac arrest with ventricular fibrillation, especially with acute ischemia, though it is not useful in the treatment of atrial arrhythmias.

The elimination half life of intravenous lidocaine is about 109 minutes, but because it is metabolized in the liver (which depends on liver blood flow), dosage should be reduced in patients with low cardiac output or who are in shock. In patients with cardiogenic shock, the half life may exceed ten hours.

Toxicity

Toxicity is most often seen when there has been an inadvertent intravascular injection of lidocaine when being used as a local anesthetic. Central nervous system toxicity manifests as tinnitus, dizziness, paresthesia (pins and needles), confusion and – in more severe cases – seizures or coma. Severe toxicity may also result in cardiovascular system collapse or ventricular fibrillation.

Related Information

  • Benzocaine
  • Bupivacaine
  • Procaine
  • Cocaine


Read more at Wikipedia.org


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Adolor to start Phase 2 trial for sterile lidocaine patch
From Journal of Drugs in Dermatology, 1/1/06

Adolor Corporation has started a Phase 2 trial to evaluate the safety and efficacy of its sterile lidocaine patch for post-surgical incision pain. The study is a multicenter randomized double-blind placebo-controlled trial in which 30 patients undergoing hernia repair will be treated with the lidocaine patch or placebo. Safety, tolerability, and efficacy based on an 11-point pain scale will be assessed at 72 hours. The sterile lidocaine patch is a sustained release lidocaine preparation intended to decrease lapses in pain control for hospital and office based procedures. Data are expected in early 2006.

COPYRIGHT 2006 Journal of Drugs in Dermatology, Inc.
COPYRIGHT 2006 Gale Group

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