You routinely administer combination drugs. . .but do you know what's in them? To find out, match each combination of ingredients in section II with its correct name in Section I.
_____1. Percodan (Endo)
_____2. Cosopt (Merck)
_____3. Trinalin (Schering)
_____4. Loestrin Fe (Parke-Davis)
_____5. Unasyn (Pfizer)
a. oxycodone HCl, 4.5 mg; oxycodone terephthalate, 0.38 mg; aspirin, 325 mg
Prescribed to relieve moderately severe pain, this Schedule II combination contains the analgesics oxycodone, an opioid, and aspirin, a nonopioid. Warn your patient to gauge his response before driving-the drug may cause dizziness, sedation, nausea, and vomiting.
b. norethindrone acetate, 1.0 mg, 1.5 mg; ethinyl estradiol, 20 mcg, 30 mcg; ferrous fumarate, 75 mg
A woman with dysmenorrhea may receive this oral contraceptive to decrease bleeding and the risk of anemia. The first 21 white or green tablets contain norethindrone, a progestin, and ethinyl estradiol, an estrogen. The 7 brown tablets contain ferrous fumarate (iron)tell your patient not to skip them.
c. each ml contains: dorzolamide, 20 mg; timolol, 5 mg
Both drugs in this combination help decrease elevated intraocular pressure, such as that caused by open-angle glaucoma and ocular hypertension: dorzolamide, a carbonic anhydrase inhibitor, and timolol, a nonselective beta-blocker. Tell your patient to administer doses at least 10 minutes apart from other topical ophthalmic drugs.
d. ampicillin sodium, 1 gram, 2 grams; sulbactam sodium, 0.5 gram, 1 gram
Used to treat intra-abdominal and gynecologic infections caused by beta-lactamase producing Staphylococcus aureus, Escherichia coli, and Klebsiella, this combination contains ampicillin, a penicillin-type antibiotic, and sulbactam sodium, which inactivates beta-lactamase enzymes. Doses may be administered I.M. or I.V.
e. azatadine maleate, 1 mg; pseudoephedrine sulfate, 120 mg
This combination is prescribed to relieve allergy symptoms. Azatadine is an antihistamine; pseudoephedrine, a decongestant. Warn your patient that the medication can cause drowsiness and dizziness and to see how she reacts before doing anything that requires alertness.
BY MARCY PORTNOFF GEVER, PHARMD. MED
Marcy Portnoff Gever is an independent pharmacist consultant and educator in Ringoes, N.J.
Copyright Springhouse Corporation Mar 2004
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