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Lomotil

Lomotil is the trade name of a popular oral anti-diarrheal drug in the United States, manufactured by Pfizer. more...

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Its active ingredients are diphenoxylate and atropine. Diphenoxylate is anti-diarrheic and atropine is anticholinergic. Diphenoxylate is chemically related to the narcotic drug meperidine. Atropine is used to treat diarrhea that is not caused by infection with bacteria. The medication works by slowing down the movement of the intestines.

The inactive ingredients of Lomotil are cherry flavor, citric acid, ethyl alcohol 15%, FD&C Yellow No. 6, glycerin, sodium phosphate, sorbitol, and water.

Other trade names for the same therapeutic combination are Lofene, Logen, Lomanate and Lonox, among others. In other countries, Lomotil may have other names.

Contraindications

Absolute contraindications for Lomotil are:

  • Allergy to diphenoxylate or atropine
  • Presence of jaundice
  • Diarrhea associated with pseudomembranous enterocolitis, diarrhea caused by antibiotic treatment, or diarrhea caused by enterotoxin-producing bacteria.

Interactions

Interactions with other drugs:

  • Sedatives
  • Barbiturates
  • Antidepressants (e.g., Elavil, Prozac, Paxil)
  • Tranquilizers (e.g., Valium, Xanax)
  • Monoamine oxidase inhibitors (e.g., Nardil, Parnate)

Diarrhea that is caused by some antibiotics such as cefaclor, erythromycin or tetracycline can worsen with Lomotil.

Safety

The drug combination is generally safe in short-term use and with recommended dosage. Long-term use may present problems of mild drug dependency. The dosage should be reduced after 48 h.

Lomotil may cause several side-effects, such as dry mouth, headache, constipation and blurred vision. Since it may cause also drowsiness or dizziness, Lomotil should not be used by motorists, operators of hazardous machinery, etc. It is not recommended for children under two years of age.

Toxicity

Lomotil may cause serious health problems when overdosed. Signs and symptoms of adverse effects may include any or several of the following: convulsions, respiratory depression (slow or stopped breathing), pinpoint or dilated eye pupils, nystagmus (rapid side-to-side eye movements), erythema (flushed skin), gastrointestinal constipation, nausea, vomiting, paralytic ileus, tachycardia (rapid pulse), drowsiness, coma and hallucinations. Symptoms of toxicity may take up to 12 hours to appear.

Treatment of Lomotil overdose must be initiated immediately after diagnosis and may include the following: emesis (indiced vomiting), gastric lavage, ingestion of activated charcoal, laxative and a counteracting medication (narcotic antagonist).

Prompt and thorough treatment of overdose leads to a favorable outcome. After a narcotic antagonist is given, recovery is usually within 24 to 48 hours. Children are at risk of a very poor outcome and must be kept for observation.

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Diarrhea and wound healing
From Advances in Skin & Wound Care, 7/1/03 by Collins, Nancy

Q: Many of my patients have pressure ulcers on the coccyx or sacrum. Frequent bouts of diarrhea make it difficult to care for these ulcers and healing is often impeded. Can you provide guidelines on managing diarrhea?

A: Diarrhea is characterized by frequent loose or liquid stool. If stool contaminates a pressure ulcer, treating and healing the wound may be more difficult. Prompt and effective treatment of diarrhea involves a multidisciplinary approach to identify its cause and begin the proper nutritional, medical, and pharmaceutical regimen.

Causes and Types of Diarrhea

Diarrhea is a symptom of many disorders and diseases. The first step in treating diarrhea is to identify its cause. Table 1 lists several common causes of diarrhea.

The 3 most common types of diarrhea are watery, fatty, and small-volume. Identifying the type of diarrhea may help determine its cause. Watery diarrhea occurs when the amount of water and electrolytes moving into the intestinal mucosa exceeds the amount absorbed into the bloodstream.1 Watery diarrhea may be classified into 2 subtypes: osmotic or secretory. To determine which type is present, identify if the diarrhea abates with fasting. Osmotic diarrhea is relieved by fasting; secretory diarrhea is not.2 Watery osmotic diarrhea usually accompanies lactose intolerance, dumping syndromes, and enteral feeding intolerances. Watery secretory diarrhea is a sign of bacterial enterotoxins and viruses. Fatty diarrhea, or steatorrhea, usually accompanies conditions associated with malabsorption, such as chronic pancreatitis or short-bowel syndrome. Small-volume diarrhea may accompany diverticulosis of the colon.

Bloody stool or black tarry stool may indicate a more serious condition and should not be confused with common diarrhea. Black tarry stool, or melena, usually indicates that blood is coming from the upper part of the gastrointestinal tract. Maroon or red bloody stool, called hematochezia, usually suggests that blood is coming from the large intestine or rectum. These conditions warrant prompt medical attention and testing. Occasionally, the ingestion of black licorice, lead, iron supplements, or blueberries can cause black stool and false melena. A fecal occult blood test can be administered to rule out false melena.

Medical Treatment

A thorough medical workup may help identify the cause of diarrhea and, thereby, direct the treatment plan. The first step is to obtain a detailed medical and nutritional history, including use of dietetic food products. Many diabetic patients replace sugary foods with dietetic foods that contain sugar alcohols such as sorbitol, mannitol, and xylitol. These products frequently cause diarrhea and should be eliminated from the diet if they are not well tolerated. Because many medications contain sugar alcohols, the patient's medication list should also be reviewed and appropriate substitutes recommended. Magnesium-containing medications and supplements may also cause diarrhea and should be monitored as well.3

A stool culture may be ordered to identify parasites, bacteria, or other signs of infection. Stool may also be examined for fecal white blood cells and Clostridium difficile toxin. Blood tests may be ordered to rule out or confirm the presence of certain diseases. A fasting or elimination test can be performed to determine if diarrhea is caused by a food allergy or intolerance. Finally, a sigmoidoscopy or colonoscopy may be performed.

Preventing Dehydration

The main goal in the treatment of diarrhea is to prevent dehydration and electrolyte imbalance. Losses of potassium and sodium should be corrected as soon as possible by providing a proper oral rehydration solution. Water does not contain the necessary electrolytes for oral rehydration therapy, and sugary juices, such as apple juice, may worsen diarrhea. Caffeinated and alcoholic beverages should also be limited. Proper solutions may be homemade or purchased from a medical nutrition supplement company. Commercially available mixtures include EquaLYTE (Ross Products, Columbus, OH) and Ceralyte (Cera Products, Jessup, MD). Sport drinks such as Gatorade (Stokely-Van Camp, Inc, a subsidiary of Quaker Oats, Chicago, IL) may , also be used. EquaLYTE is an enterai rehydration solution that may be tube-fed or administered orally. It contains electrolytes with a sodium content that is equal to half-normal saline. It also contains fructooligosaccharides and provides 100 calories per liter.4 Ceralyte, a rice-based solution that may be purchased in powder or liquid form, is available in several flavors.5

Careful laboratory monitoring of sodium, potassium, chloride, blood urea nitrogen/creatinine ratio, and albumin should be performed. Patients with a history of hypertension or heart failure should be monitored closely when given high-sodium solutions.

Medical Nutrition Therapy

Although medical nutrition therapy is determined by the diarrhea's specific cause, some general recommendations apply. In acute cases, it may be necessary to begin treatment by having the patient not eat or drink anything for 12 hours. Intravenous fluids may be ordered if dehydration is present. Oral fluids should be started as soon as tolerated. The initial oral diet should consist of broth, tea, and toast, with additional foods added as tolerated. High-sugar foods should be avoided. Foods containing probiotics, such as yogurt with live cultures, may be given, especially to patients taking antibiotics. Small, frequent meals throughout the day are best tolerated. Dairy products and wheat products should be reintroduced slowly. Foods high in roughage, such as raw fruits and vegetables, should be avoided. Soluble fiber, which dissolves in water, should be added to the diet as tolerated. Soluble fiber, including pectin, is found in oatmeal, apples, bananas, beans, and psyllium. Kannana Banana Flakes (Corpak MedSystems, Wheeling, IL) may be used in oral and tube-fed diets to provide soluble fiber. If lactose intolerance is present, a lactose-free diet may be prescribed. If stcatorrhea is present, replace fat-soluble vitamins with a vitamin supplement. Drugs such as Imodium, Pepto-Bismol, Kaopectate, or Lomotil may be ordered as needed. If complete bowel rest is needed, total parenteral nutrition may be provided.

Most cases of diarrhea will resolve with time and a multifaceted treatment plan, including a careful history, physical and medical workup, medical nutrition therapy, and drugs. Despite all of these approaches, however, some patients may fail to improve and a fecal incontinence pouch or operative diversion may be necessary until the wound heals. In every scenario, interventions should be carefully documented. If one approach docs not work, there is always another idea or product to try.

References

1. Williams SR. Nutrition and Diet Therapy. 8th ed. St Louis, MO: Mosby-Year Book, Inc; 1997. p 527.

2. Robinson GE, Leif BJ. Nutrition Management & Restorative Dining for Older Adults. Chicago, IL: American Dietetic Association; 2001. p 239.

3. Escott-Stump S. Nutrition and Diagnosis-Related Care. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2002. p 295.

4. Ross Products. Ross product literature, [on-line] Available at http://www.ross.com. Last accessed December 2, 2002.

5. Cera Products. Ceralyte product literature, [on-line] Available at http://www.ceralyte.com. Last accessed December 2, 2002.

Nancy Collins, PhD, RD, LD/N

Nancy Collins, PhD, RD, LD/N, is a registered and licensed dietitian in private practice in Pembroke Pines, FL For the past decade, she has served as a consultant to health care institutions on issues regarding regulatory compliance, clinical nutrition, and food service management and as a medical-legal expert to law firms involved in health care litigation. Questions for future columns may be sent to Dr Collins at NCtheRD@aol.com.

Copyright Springhouse Corporation Jul/Aug 2003
Provided by ProQuest Information and Learning Company. All rights Reserved

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