The hERG cardiac potassium channel; structure, function, and long QT syndrome.
Ed. by Derek J. Chadwick and James Goode.
John Wiley & Sons
Novartis Foundation symposium; 266
The human ether-a-go-go-related gene (hERG) channel is one of several ion channels involved in the normal action potential repolarization in cardiac myocytes. This book aims to provide a better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias. Contributions from basic, pharmaceutical, and clinical sciences and regulatory authority perspectives examine the structure and function of hERG, the molecular basis for compound binding, and preferred preclinical test systems. Coverage encompasses hERG channel gating, trafficking, and pharmacology, and mechanisms of drug-induced LQTS.
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