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Lufenuron

Lufenuron is an enzyme and the active ingredient in the anti-flea veterinary medicine Program. more...

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Lufenuron is stored in the animals body fat and transferred to adult fleas through their bite. Adult fleas transfer it to their eggs by its presence in the mother fleas blood or by the larva feeding on digested blood.

The method of action for lufenuron is to inhibit the production of chitin in larval fleas. Without chitin a larval flea will never develop an exoskeleton. Attacking the ability to create chitin also makes lufenuron an effective remedy against fungal infections and some internal parasites, such as heartworm or ringworm.

It has no known toxic effects at any dosage on humans or other animals in the environment that do not depend on chitin though the orally administered pills sometimes cause an upset stomach with acid reflux.

  • CAS Number: 103055-07-8
  • U.S. EPA PC Code: 118205

Read more at Wikipedia.org


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Taking The Bite Out Of Fleas And Ticks - products for animal pest control and proper usage
From FDA Consumer, 7/1/01 by Linda Bren

Fleas are truly devoted to their work. In one day, a single flea can bite your cat or dog more than 400 times. During that same day, the flea can consume more than its body weight of your pet's blood. And before it's through, a female flea can lay hundreds of eggs on your pet, ensuring that its work will be carried on by generations to come.

Fleabites may be merely a nuisance to some pets, but to others, they can be dangerous. They can cause flea allergy dermatitis--an allergic reaction to proteins in flea saliva. A pet's constant scratching to rid itself of fleas can cause permanent hair loss and other skin problems. A pet can get a tapeworm if it eats a flea that has one. And flea feasts on your pet's blood can lead to anemia and, in rare cases, death.

But fleas are not your pet's only nemesis. Tick bites can give your pet such infections as Lyme disease, ehrlichiosis, and Rocky Mountain spotted fever. And ticks can give those same infections to you.

The good news is fleas and ticks are getting easier to control. "In the last five years, flea products have greatly improved," says Ann Stohlman, V.M.D., a veterinarian at the Food and Drug Administration's Center for Veterinary Medicine. Some flea prevention treatments also help kill ticks.

In years past, veterinarians recommended getting rid of fleas by simultaneously "bombing" the house with insecticide, spraying the yard, and dipping the dog or cat, says Stohlman. Today, treating only the pet often takes care of the problem. "But if there is a severe flea infestation or if the problem persists, you may still need to treat the pet's environment," she says.

Types of Flea and Tick Products

Hundreds of pesticides, repellents, and growth inhibitors are approved or licensed to control fleas and ticks on cats and dogs or in their environment. (See "Pet Products to Control Pests" on page 8). Products range from oral medications that require a veterinarian's prescription to collars, sprays, dips, shampoos, and powders that are available at retail stores. "Spot-ons," liquid products applied directly to the pet's skin, often behind the neck, are among the latest weapons to be developed to fight, fleas and ticks. Some products kill only ticks or adult fleas--others break the flea life cycle by preventing flea eggs from developing into adult fleas.

Some flea and tick products are not prescription drugs, yet are available only through veterinarians. "This is because the manufacturer chooses to sell its products through vets, so that the vet can provide important safety information to the client," says Elizabeth Luddy, D.V.M., an FDA veterinarian.

The Preventic collar is one such product. The collar kills ticks by interfering with a tick's ability to feed on dogs. It contains the insecticide amitraz, which paralyzes the tick's mouthparts. Amitraz should not be used on dogs that are sickly, pregnant, or nursing, or with certain drugs that may interact with the insecticide. The manufacturer, Virbac Corp., Fort Worth, Texas, sells the collar through veterinarians, who can ensure that a dog is healthy and can use the collar safely.

When to Treat

It's best to treat your pet at the beginning of flea and tick season, says Stohlman. The severity and length of the flea season vary depending on which part of the country you live in. "It can last four months in some places, but in other places, like Florida, fleas can live all year long," says Stohlman. Fleas also can live inside a warm house year round.

In many areas, September is often the worst month for flea infestation. In most parts of the United States, the greatest chance of infection by a tick bite is May through September, the period of greatest tick activity by "nymphs." Nymphs are the stage of tick development that occurs after they have had their first blood meal and molt, and before they become adults.

Lyme Disease

About 200 species of ticks live in the United States. Some of these can transmit infectious diseases, such as Lyme disease, to pets and humans. Studies indicate that dogs are 50 percent more susceptible to Lyme disease than humans, according to the American Veterinary Medical Association. Lyme disease is caused by a bacterium transmitted through the bite of the deer tick, also called the black-legged tick, which is no larger than the head of a pin.

Typical symptoms of Lyme disease in dogs include joint soreness and lameness, fever, and loss of appetite. Symptoms in humans include fatigue, chills and fever, headache, muscle and joint pain, swollen lymph nodes, and a red, circular skin rash.

Some of the products shown in "Pet Products to Control Pests" (page 8) can control ticks on your pet. Many other tick repellents for pets and people are available in stores.

Read the Label, Talk to Your Vet

When buying a flea or tick product, it's important for pet owners to read the label and follow the directions carefully, says Steve Hansen, D.V.M., director of the ASPCA Animal Poison Control Center. Hansen reports a "serious problem" with the misuse of dog flea and tick control products containing the insecticide permethrin. Dogs can tolerate concentrated permethrin, but "it can be lethal to cats," says Hansen. "Never use products on cats that are labeled for use on dogs only."

If the label states that the product is for animals of a certain age or older, don't use the product on pets that are younger, says Stohlman. Flea combs, which can pick up fleas, flea eggs, and ticks, may be useful on puppies and kittens that are too young for flea and tick products.

Talk to your vet about the flea and tick product most appropriate for your pet, Luddy advises. The product you use will depend on your pet's health and age, whether your pet is a cat or a dog, and whether it's an indoor or outdoor pet. Also check with your vet to determine whether the Lyme vaccine is right for your dog.

Rabbits, ferrets, and some other furry pets also can have flea and tick infestations. Reptiles, such as snakes, can get infections and anemia from tick bites. No flea or tick products are marketed specifically for use in these animals. Ask your veterinarian how to treat fleas and ticks in these and other exotic pets.

How to Remove a Tick

If a tick is removed within 24 hours, the chances of it transmitting Lyme disease or other infections are much less. The illustrations show how to remove a tick properly. Use fine-point tweezers to grasp the tick as close to the skin as possible. Pull gently. Avoid squeezing the body of the tick. Clean the site of the bite, your hands and the tweezers with disinfectant. You may want to wear protective gloves.

[ILLUSTRATION OMITTED]

You also may want to place the tick in a small container, like a pill container, and bring it to your vet for identification. Never use a burned match, petroleum jelly, or nail polish to try to remove ticks. These methods are ineffective.

RELATED ARTICLE: Using Flea and Tick Products Safely

* Read the label carefully before use. If you don't understand the wording, ask your veterinarian or call the manufacturer.

* Follow directions exactly. If the product is for dogs, don't use it on eats or other pets. If the label says use weekly, don't use it daily. If the product is for the house or yard, don't put it directly on your pet.

* After applying the product, wash your hands immediately with soap and water. Use protective gloves if possible.

* If your pet shows symptoms of illness after treatment, call your veterinarian Symptoms of poisoning may include poor appetite, depression, vomiting, diarrhea, or excessive salivation.

* Store products away from food and out of children's reach.

--L.B.

COPYRIGHT 2001 U.S. Government Printing Office
COPYRIGHT 2004 Gale Group

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