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Luvox

Fluvoxamine (sold as Luvox®, Faverin® and Fevarin®) is a selective serotonin reuptake inhibitor. It is used primarily to treat depression, anxiety and OCD. more...

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Although its effects are similar to other SSRIs, it acts on the body's neurochemistry differently. For this reason, fluvoxamine can be of benefit to patients who experience unusual or limiting side-effects from other antidepressants. Fluvoxamine also appears to cause fewer side-effects than other SSRIs, particularly in relation to loss of sex-drive.

Fluvoxamine has the shortest half-life of all the SSRIs. Its mean serum half-life is 15 hours after a single dose, and 17 to 22 hours after repeated doses.

Fluvoxamine causes many drug-drug interactions due to inhibition of metabolism mediated by several cytochrome P450 oxidases. Examples of substances that have higher serum levels when administered together with fluvoxamine include caffeine, clozapine, olanzapine, tricyclic antidepressants, diazepam, alprazolam, propranolol, warfarin and methadone.

Effective dosage

For depression and anxiety, dosage normally starts at 50 milligrams per day, rising to 100 milligrams after a few days. It may be raised after evaluation of the effects by a doctor.

Fluvoxamine is generally only effective for OCD at 150 milligrams and above, and dosages can reach 300 milligrams or more for some patients.

Historical Relevance

In 1999, fluvoxamine came under great public scrutiny after it was discovered that Eric Harris, one of the two teenaged shooters involved in the Columbine High School massacre, had been taking the drug as treatment for depression. Many immediately pointed fingers at fluvoxamine and its manufacturer Solvay Pharmaceuticals (which sells fluvoxamine under the widely known brandname Luvox), since Solvay's own clinical trials indicated the drug had the propensity to induce "mania" in 4% of the youth who took it. Solvay, while acknowledging the risks inherent in taking an SSRI medication like fluvoxamine, downplayed any role the drug may have had in the killings. The American Psychiatric Association (A.P.A.) took a similar stance; Rodrigo Munoz, M.D., President of the A.P.A., said: "Despite a decade of research, there is little valid evidence to prove a causal relationship between the use of anti-depressant medications and destructive behavior. On the other hand, there is ample evidence that undiagnosed and untreated mental illness exacts a heavy toll on those who suffer from these disorders as well as those around them." It was also pointed out by many that Luvox was often safer than the other SSRI medications available--for example, fluoxetine (Prozac) caused mania in 6% of youth tested on the drug (versus fluvoxamine's 4%). Nonetheless, the reputation of Luvox was irreparably damaged. Sales fell, and Solvay withdrew the medication from the U.S. market in 2002; the company maintains, however, that this move had nothing to do with the safety profile of the fluvoxamine, which they still sell in many countries around the world. In the United States, fluvoxamine can only be purchased generically.

Read more at Wikipedia.org


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Missing in action: losing Tooker Gomberg
From Briarpatch Magazine, 11/1/05 by Stephen Salaff

TOOKER GOMBERG WAS a modest, gentle, easygoing but determined man. Without personal pretension or apparent aspirations for prominence or authority, Gomberg managed to inspire and unite large numbers of conscientious folk across a broad political spectrum. He proved that masses of North Americans can be reached and mobilized for progressive social change, working both within and against the establishment by pursuing a radical and principled social justice platform.

Tragically, Tooker Gomberg disappeared at the apex of his creative powers, leaving behind a rich legacy of political activism, and a lot of unanswered questions.

Gomberg, it seems, committed suicide. The story of his multi-stage dark depression and the events surrounding his disappearance during a March 2004 nervous collapse remains largely unreported.

Tooker Gomberg was a pillar of creative activism in Canada. His life-long campaign to build broad environmental and social justice coalitions in Montreal, Edmonton, Toronto, and Halifax made him a model and mentor for many activists. According to environmental lawyer and Sierra Club of Canada Executive Director Elizabeth May, "Tooker took his philosophy from US outdoorsman, conservationist and High Sierra explorer John Muir in the 1890s and his campaign tactics from the 1960s Yippies. He was one of the most able and energetic activists ever in Canada, with equal measures of fun and uncompromising commitment." Environmentalist author Guy Dauncey also emphasized Gomberg's charismatic charm: "Tooker had a bright, witty, sharp edge, alongside his commitment and knowledge. He made people believe that working for a beautiful, safe, healthy planet could be fun, wild and passionate, as well as effective."

Gomberg was elected to Edmonton City Council in 1992. He listed his chief council initiatives in a leaflet for his Edmonton mayoralty run in 1998: adoption of water conservation; establishment of advisory boards for water conservation, public transit and the environment; establishment of an automated transit information system, and a pilot project of bicycle racks on city buses.

Gomberg and his partner Angela Bischoff, a writer and social justice advocate, left Edmonton for Toronto in May 1999, where he contested the Toronto November 2000 mayoralty election on a progressive environmental platform. After a hard-fought race, Gomberg placed second to incumbent mayor Mel Lastman, garnering over 51,000 votes. His campaign planks of municipal waste minimization and beneficial use within the City of Toronto were adopted officially by the city only months after the election, and rolled out in the September 2004 Green Bin Organics Program.

Gomberg and Bischoff relocated in September 2003 to Halifax, where Bischoff began work as a car-free transportation campaigner with the Ecology Action Centre. Some time before that, Gomberg was stricken for unknown reasons with a dark depressive mood disorder which is not uncommon among previously vigorous males entering emotionally and physiologically vulnerable middle age. This intractable illness cast a pall of despair over his outlook and disrupted his sleep pattern, from then on. Anguish and insomnia fatally clouded his judgment.

Gomberg's bicycle was found March 3, 2004, on the Macdonald Bridge. Two days later, CBC news reported, "Police say it appears Gomberg may have jumped off a bridge linking Halifax to Dartmouth."

Police services, according to Bischoff, generally hesitate to share with the media such particulars of suspected suicides. "I understand that when there is a suicide, no details are given to the media, both out of respect for the family and to prevent copycat actions," she said.

Bischoff suspects several police officers of repeating information on Gomberg's disappearance to the media. They told her that since there was no evidence of a jump, no video recording, and no witnesses, they would transfer their file to the missing persons branch, which routinely releases details to the media.

"On behalf of Halifax Regional Police," Chief of Police Frank Beazley therefore wrote to Bischoff on May 7, "I apologize for any extra burden you suffered during this difficult time as a result of our dealings with the media regarding this incident."

Indignant and aggrieved at perceived psychiatric neglect in the face of Gomberg's shattering end-of-life symptoms, Bischoff recently launched twin actions in Halifax. "Tooker's anxiety and agitation spun out of control in the weeks preceding his death," she recalls. "He had insomnia and loss of appetite. He had tried a host of therapies during his previous depression, but none seemed to improve his condition, so this time he felt he had no choice but to go with Remeron, a psychotropic pharmaceutical prescribed by his psychiatrist. The drug unmistakably agitated him, and the synergy of such restless distress with his overhanging mood disorder is a lethal mix."

"He began popping the pills, but felt worse. Under his doctor's supervision, he doubled the dosage. He was crawling under his skin with anxiety and agitation. He could not concentrate or focus. He ruminated on what he perceived to be his failures. His memories of the past and thoughts of the future took on a negative spin. He lost hope, not in the world, but in himself."

"Again he upped the dosage, this time to the maximum recommended, and two days later he jumped. Just five weeks into the drug regimen, he was dead."

In May 2005, Bischoff complained to the Nova Scotia College of Physicians and Surgeons about the failure of Gomberg's psychiatrist to identify the deepening of Gomberg's mood disorder shortly after he prescribed Remeron, and his decision to prescribe Remeron to a severely depressed patient without conducting a structured suicide assessment. The psychiatrist neglected to speak with Gomberg about the risk of self-destruction or self-harm during their talks, which Gomberg recounted, with increasing desperation, to Bischoff. Gomberg visited the therapist, for the ninth time, on the day of his disappearance, at which time the psychiatrist prescribed a tranquilizer. The College may later name the psychiatrist publicly:

In June, Bischoff petitioned Chief Medical Examiner Matthew Bowes of Nova Scotia for a "fatality inquiry" into what she claims are numerous failures in the care provided by the medical profession treating Gomberg and other grievously ill patients. The profession, she argues, freely prescribes anti-depressant medications while ignoring or downplaying their adverse reactions.

Bischoff is now preparing to embark on a Canada-wide campaign to raise awareness of the dangers of anti-depressant medications, including a national speaking tour combined with publication of a tabloid newspaper dedicated to the casualties of anti-depressant drugs.

Toronto lawyer Peter Rosenthal, who represented Gomberg in a successful assault suit against a City of Toronto security guard, said "Tooker was a very dedicated and creative progressive activist, and his early death is a tragedy for the community as well as for those close to him."

Gomberg's comrades and supporters can only speculate on the political path he might have taken had he not been felled by a seriously misunderstood mood disorder at such a critical juncture in the evolution of his philosophy and practice of inclusive, imaginative, coalition-based politics.

RELATED ARTICLE: Down on the Pharma.

by Tracey Mitchell

In June 2004, Health Canada released an advisory warning that Selective Serotonin Reuptake Inhibitors (SSRls) and Selective Noradrenatine Reuptake Inhibitors (SNRIs) may lead to increased risk of self-harm, agitation and suicidal thoughts. The Health Canada advisory, which applied to many well-known brands of antidepressants including Wellbutrin, Zyban, Celexa. Prozac. Remeron, Zoloft, Paxil, Luvox and Effexor, indicated that "a small number of patients taking these drugs may feel worse instead of better, particularly in the first few weeks of treatment when doses are adjusted."

The Health Canada warning followed a March 2004 US Food and Drug Administration statement that ordered manufacturers to place a warning label on all antidepressants, detailing the heightened risks of self-harm and suicidal thoughts in children and adolescents. In July 2005, the FDA further warned that "several recent scientific publications suggest the possibility of an increased risk for suicidal behaviour in adults who are being treated with antidepressant medications." The FDA emphasized that:

* "Adults being treated with antidepressant medications, particularly those being treated for depression, should be watched closely for worsening of depression and for increased suicidal thinking or behavior. Close watching may be especially important early in treatment, or when the dose is changed, either increased or decreased."

* "Adults whose symptoms worsen while being treated with antidepressant drugs, including an increase in suicidal thinking or behavior, should be evaluated by their health care professional."

The information contained in the above warnings is nothing new, however. As early as 1984, German regulators of Prozac stated privately: "Considering the benefit and the risk, we think this preparation totally unsuitable for the treatment of depression." Dr. David Healy, author of Let Them Eat Prozac and other books on the field of psychopharmacology, argues that drug companies and regulators have known for some time that SSRIs and SNRIs were dangerous, but have deliberately downplayed and covered up such findings.

In fact, Healy argues that diagnoses of depression have been skyrocketing precisely because pharmaceutical companies and some doctors stand to gain. He calls this phenomenon "a wholesale creation of depression on so extraordinary and unwarranted a scale as to raise grave questions about whether pharmaceutical and other health care companies are more wedded to making profits from health than contributing to it."

Stephen Salaff is a Toronto-based freelance energy and environment writer, who is thankful for his very fortuitous recovery, during early middle age, from six years of dysphoric depression, a state of constant sadness.

COPYRIGHT 2005 Briarpatch, Inc.
COPYRIGHT 2005 Gale Group

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