Mefenamic acid

Mefenamic acid (IUPAC nomenclature: N-2,3-xylylanthranilic acid) is a non-steroidal anti-inflamatory drug used to treat pain, including menstrual pain. It is commercially available as Ponstel®. It is also prescribed as an antipyretic drug. It is typically prescribed for oral administration. more...

Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis.

Patients with known liver deficiency may be prescribed lower doses. This is because hepatic metabolism plays a significant role in mefenamic acid elimination. Kidney defficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be precribed mefenamic acid.

Side effects

Mefenamic acid is known to cause an upset stomach, therefore it is recommended to take prescribed doses together with food or milk. Instances of drowsiness may also occur. As such, it is recommended to avoid driving or consuming alcohol while taking this medication.

Other known mild side effects of mefenamic acid include headaches, nervousness and vomiting. Serious side effects may include diarrhea, bloody vomit, blurred vision, skin rash, itching and swelling, sore throat and fever. It is advised to consult a doctor immediately if these symptoms appear while taking this medication.

Sources

• MedlinePlus Drug Information: Mefenamic Acid. Last accessed September 28, 2005.
• Ponstel Pharmacology, Pharmacokinetics, Studies, Metabolism - Mefenamic Acid - RxList Monographs. Last accessed September 28, 2005.

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