Methcathinone chemical structure
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Methcathinone

Methcathinone is an addictive recreational drug that is cheap and simple to synthesize. It is usually snorted, but can be smoked, injected, or taken orally. Methcathinone is currently a DEA Schedule I chemical. more...

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History

Methcathinone was first synthesized in Germany in 1928. It was used in the Soviet Union during the 1930s and 1940s as an anti-depressant. Since the 1960s, methcathinone has been used as a recreational drug in the Soviet Union.

Circa 1994, the United States government informed the UN Secretary-General of its opinion that methcathinone should be added to Schedule I of the Convention on Psychotropic Substances.

Chemistry

Methcathinone is very similar in structure to cathinone, a stimulant alkaloid occurring in the shrub Catha edulis (Khat), the synthetic stimulant methamphetamine, and other phenethylamines.

Methcathinone has a single asymmetric carbon atom, thus yielding enantiomeric + and - forms. Chemical Abstract Services registry numbers for the racemic base and hydrochloride forms are 5650-44-2 and 49656-78-2, respectively. The Chemical Abstract Services registry numbers for the base and hydrochloride forms of the S absolute stereochemical configuration are 112117-24-5 and 66514-93-0, respectively.

Various names for methcathinone include:

  • 2-(methylamino)-propiophenone
  • α-methylamino-propiophenone
  • α-N-methyl-aminopropiophenone
  • 2-(methylamino)-1-phenylpropan-1-one
  • N-methylcathinone
  • N-monomethylcathinone
  • Methylcathinone
  • AL-464 (L isomer)
  • AL-422 (racemate)
  • AL-463 (D-isomer)
  • UR1431
  • UR(W)1431

Methcathinone hydrochloride increases spontaneous rodent locomotor activity, potentiates the release of radio-labelled dopamine from dopaminergic nerve terminals in the brain, and causes appetite suppression.

Methcathinone is most commonly made by the oxidation of ephedrine. Oxidation of ephedrine to methcathinone requires almost zero chemistry experience, making it easy to synthesize. Potassium permanganate (KMnO4) is most the commonly used as the oxidant.

Methcathinone can also be synthesized via the oxidation of l-ephedrine using sodium dichromate and sulfuric acid. This process is just as simple as oxidizing the ephedrine with potassium permanganate.

Synthesizing methcathinone from either potassium permanganate or various chromates is considered undesirable because of the low yields. A method that yields more methcathinone is oxidizing ephedrine with sodium hypochlorite.

Methcathinone acts on the body & brain much like methamphetamine & amphetamine do.

Effects

The effects of methcathinone are similar to those of methamphetamine, but generally less intense, and often more euphoric. The effects have been compared to those of cocaine, since it commonly causes hypertension (elevated blood pressure) and tachycardia (elevated heart rate). Reported effects include:

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STATE DIGEST
From Milwaukee Journal, The, 4/3/95

Superintendent to face trial on theft charges

Siren There is sufficient evidence to prosecute the superintendent of the Siren School District on theft and misconduct charges, a judge has ruled.

Gerald Mikunda, 56, has been bound over for trial at a preliminary hearing in Burnett County Circuit Court. Mikunda, who has taken an unpaid leave of absence from his job, is charged with theft, concealing stolen property and eight counts of misconduct by a public official.

The Sheriff's Department said a February search of Mikunda's home uncovered more than 50 items belonging to the school district, including tools, a dehumidifier, an outboard motor and a roll of fencing.

Two women killed in Vernon County crash

Viroqua Two women were killed in a one-car crash early Sunday, according to the Vernon County Sheriff's Department.

Jennifer L. Burckhardt, 20, of Viroqua, and Shannon I. Burke, 20, of La Crosse, were killed when the car they were in overturned on Highway I in the Town of Kickapoo shortly before 1 a.m. Sunday.

Jason W. Dore, 21, of Reedstown, was injured in the crash and was taken to Lutheran Hospital in La Crosse, where he was in fair condition Sunday afternoon, a nursing supervisor said.

A Vernon County sheriff's spokesman said officials didn't know who was driving the car. The accident remained under investigation.

In other traffic fatalities, Lloyd A. Remington, 37, of Escanaba, Mich., was killed Saturday when a car hit him as he walked in his hometown, state police said Sunday.

Sun Prairie man sues over burns from coffee

Madison A Sun Prairie man claims in a lawsuit filed against Burger King that he suffered burns from coffee spilled on him at an Eau Claire outlet.

Robert G. King's lawyer filed the suit in Dane County Circuit Court, claiming that the restaurant sold a dangerous product.

King, who was traveling through Eau Claire on business on May 21, was burned when a cup of coffee was spilled on him at a drive-up window, his attorney Robert Gingras said.

The serving temperature of the restaurant's coffee was checked and was "found to have exceeded 170 degrees," Gingras said.

Mike DeRosa, owner of Burger King restaurants in Eau Claire, said he could not comment because he had not seen the suit.

Gateway Technical names new president

Racine Carole Johnson, chancellor of the Minnesota Technical College System, has been named president of Gateway Technical College.

The Gateway Technical College District Board voted unanimously Thursday to offer Johnson, 49, a three-year contract with a starting annual salary of $98,000. She is expected to start July 10.

The board had narrowed the search to three candidates last month.

Four men sent to prison for making, selling CAT

Marquette, Mich. Four men have been sentenced to federal prison terms for operating a methcathinone business out of a secluded cabin and selling the inexpensive, highly addictive drug.

Ronald Stapleton, 42, of Iron River was sentenced to 13 years in prison for selling the recipe, maintaining lab equipment and conspiring with more than 15 people in Wisconsin, Indiana and Illinois to make the drug.

Also sentenced to prison were Paul LeClaire, 37, of L'Anse, four years; Robet Lundy, 36, of L'Anse, four years; and Scott Skibo, 32, of Chetopa, Kan., nine years.

Methcathinone, which is known as "cat" and is cheap to make, is made from battery acid, lye and acetone.

From Journal Sentinel staff and wire reports

Copyright 1995
Provided by ProQuest Information and Learning Company. All rights Reserved.

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