Find information on thousands of medical conditions and prescription drugs.

Microscopic polyangiitis

Microscopic polyangiitis is an ill-defined autoimmune disease which usually presents with pulmonary bleeding and anemia. Laboratory tests show an increased sedimentation rate, reduced red blood count, antineutrophil cytoplasmic antibodies (ANCA) directed against myeloperoxidase (a constituent of neutrophil granules). and protein and red blood cells in the urine. The test for anti-glomerular basement membrane antibody (GBM), which is positive in Goodpasture's syndrome, is negative. more...

Home
Diseases
A
B
C
D
E
F
G
H
I
J
K
L
M
Mac Ardle disease
Macroglobulinemia
Macular degeneration
Mad cow disease
Maghazaji syndrome
Mal de debarquement
Malaria
Malignant hyperthermia
Mallory-Weiss syndrome
Malouf syndrome
Mannosidosis
Marburg fever
Marfan syndrome
MASA syndrome
Mast cell disease
Mastigophobia
Mastocytosis
Mastoiditis
MAT deficiency
Maturity onset diabetes...
McArdle disease
McCune-Albright syndrome
Measles
Mediterranean fever
Megaloblastic anemia
MELAS
Meleda Disease
Melioidosis
Melkersson-Rosenthal...
Melophobia
Meniere's disease
Meningioma
Meningitis
Mental retardation
Mercury (element)
Mesothelioma
Metabolic acidosis
Metabolic disorder
Metachondromatosis
Methylmalonic acidemia
Microcephaly
Microphobia
Microphthalmia
Microscopic polyangiitis
Microsporidiosis
Microtia, meatal atresia...
Migraine
Miller-Dieker syndrome
Mitochondrial Diseases
Mitochondrial...
Mitral valve prolapse
Mobius syndrome
MODY syndrome
Moebius syndrome
Molluscum contagiosum
MOMO syndrome
Mondini Dysplasia
Mondor's disease
Monoclonal gammopathy of...
Morquio syndrome
Motor neuron disease
Motorphobia
Moyamoya disease
MPO deficiency
MR
Mucopolysaccharidosis
Mucopolysaccharidosis...
Mullerian agenesis
Multiple chemical...
Multiple endocrine...
Multiple hereditary...
Multiple myeloma
Multiple organ failure
Multiple sclerosis
Multiple system atrophy
Mumps
Muscular dystrophy
Myalgic encephalomyelitis
Myasthenia gravis
Mycetoma
Mycophobia
Mycosis fungoides
Myelitis
Myelodysplasia
Myelodysplastic syndromes
Myelofibrosis
Myeloperoxidase deficiency
Myoadenylate deaminase...
Myocarditis
Myoclonus
Myoglobinuria
Myopathy
Myopia
Myositis
Myositis ossificans
Myxedema
Myxozoa
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Medicines

This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections.

The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine.

Read more at Wikipedia.org


[List your site here Free!]


Cytopathic changes of herpes simplex virus in mechanically ventilated patients: what does it mean?
From CHEST, 10/1/05 by Howard S. Weiss

PURPOSE: Herpes Simplex Virus(HSV) causes tracheobronchitis and pneumonitis in critically ill patients. The characteristic endobronchial appearance is mucosal ulceration and membrane formation. We describe a series of critically ill patients with a normal endobronchial exam and cytopathic changes of HSV.

METHODS: We reviewed all bronchoscopies performed in mechanically venilated patients in the medical ICU between October 2003 and March 2005 for evidence of mucosal lesions and cytopathic changes of HSV. Data including age, cause of respiratory failure, duration of mechanical ventilation and hospitalization prior to diagnosis, and level of HSV-1 IgG and IgM antibody(Ab)titers were recorded.

RESULTS: Of 52 bronchoscopies performed, 7 subjects with cytopathic changes of HSV were identified (13.5%) and one with bronchoscopic features of HSV. This patient was immunosupressed and was excluded. The average age was 64.9 yrs (49-84 yrs). The duration of ventilation prior to diagnosis was 9.4d (0-14) and of hospitalization was 15.1d (8-47). HSV-1 Ab titers were obtained in 4 of 7 subjects. The HSV-1 IgG Ab was elevated in 4 of 4 subjects(100%)with an average level of 31.0(normal<0.90). The HSV-1 IgM Ab titer was elevated in 2 of 4 subjects with an average level of 1.3 of those with elevated levels (normal<0.91). Respiratory failure (RF) was due to pneumonia or atelectasis in all but one patient, who had microscopic polyangiitis. Five patients received therapy with acyclovir. No specific clinical features were seen in the subjects with HSV cytopathic changes compared to the rest of the sample.

CONCLUSION: Cytopathic changes of HSV without obvious airway or parenchymal involvement are common in critically ill ventilated patients. To our knowledge, this has not been previously described in RF due to pneumonia or atelectasis. All cases occurred in fall and winter months (October to February).

CLINICAL IMPLICATIONS: The significance of HSV cytopathic changes in critically ill ventilated adults and whether antiviral treatment is beneficial remains unknown. This may represent true herpes infection or that of another etiologic agent. Further studies are indicated to define whether treatment is necessary.

DISCLOSURE: Howard Weiss, None.

Howard S. Weiss DO * Peter Spiegler MD Maritza L. Groth MD Winthrop University Hospital, Mineola, NY

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

Return to Microscopic polyangiitis
Home Contact Resources Exchange Links ebay