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Mumps

Mumps or epidemic parotitis is a viral disease of humans. Prior to the development of vaccination, it was a common childhood disease worldwide, and is still a significant threat to health in the third world. more...

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Symptoms of mumps tend to be mild, such as painful swelling of the salivary glands and testicles, rash and fever. In teenagers and adults, the symptoms can be more severe and complications (such as infertility or subfertility -- PMID 8692089, PMID 2368216, PMID 2100952) are relatively common, although still rare in absolute terms. The disease is generally self-limiting, and there is no specific treatment apart from controlling the symptoms with painkillers.

Causes and risks

The mumps are caused by a paramyxovirus, and is spread from person to person by saliva droplets or direct contact with articles that have been contaminated with infected saliva. The parotid glands (the salivary glands between the ear and the jaw) are usually involved. Unvaccinated children between the ages of 2 and 12 are most commonly infected, but the infection can occur in other age groups. Orchitis (swelling of the testes) occurs in 10-20% of infected males, but sterility only rarely ensues; a viral meningitis occurs in about 5% of those infected. In older people, other organs may become involved including the central nervous system, the pancreas, the prostate, the breasts, and other organs.

The incubation period is usually 12 to 24 days. Mumps is generally a mild illness in children in developed countries. After adolescence, mumps tends to affect the ovary, causing oophoritis, and the testis, causing orchitis. The mature testis is particularly susceptible to damage from mumps which can lead to infertility. Adults infected with mumps are more likely to develop severe symptoms and complications.

Symptoms

Symptoms of mumps may include:

  • facial pain
  • swelling of the parotid glands (in 60%-70% of cases)
  • fever
  • headache
  • sore throat
  • swelling of the temples or jaw (temporomandibular area)
  • Additional symptoms that may be associated with this disease (in 20 to 30% of cases):
    • testicular pain (in boys and men)
    • testicular enlargement (in boys and men)
    • scrotal swelling (in boys and men)
    • abdominal pain due to ovarian swelling (in girls and women)

Signs and tests

A physical examination confirms the presence of the swollen glands. Usually the disease is diagnosed on clinical grounds and no confirmatory laboratory testing is needed. If there is uncertainty about the diagnosis, serology for the virus may be carried out.

Treatment

There is no specific treatment for mumps. Symptoms may be relieved by the application of intermittent ice or heat to the affected neck area, acetaminophen (paracetamol) for pain relief (aspirin is discouraged in children with a viral illness because of the risk of Reye's syndrome). Warm salt water gargles, soft foods, and extra fluids may also help relieve symptoms.

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Is there a link between MMR vaccine and autism? - Tips from Other Journals - measles, mumps, and rubella vaccine - Abstract
From American Family Physician, 2/15/03 by Bill Zepf

Concern over a possible link between the measles, mumps, and rubella (MMR) vaccine and autism has led to a number of retrospective and prospective studies; however, none has confirmed an association. The World Health Organization and other groups have called for further investigations on a population-based scale, which would have more statistical power to detect a possible link. Madsen and colleagues present data from a retrospective cohort study of more than 500,000 children born in Denmark between 1991 and 1998.

The MMR vaccine was used in Denmark beginning in 1987, and the national vaccination program recommended that children be vaccinated at 15 months and 12 years of age. The MMR vaccine used in Denmark contained the same vaccine strains as the U.S. version. Vaccination data were obtained from the Danish National Board of Health, and diagnoses of autism were obtained from the Danish Psychiatric Central Register, which tracks all psychiatric treatment centers in Denmark.

Within a study cohort of 537,303 subjects, 440,655 children received the MMR vaccine. Follow-up data were lost for 5,028 children because of death or emigration during the study period. The mean age at the time of the first dose of MMR vaccine was 17 months, and 98.5 percent of those vaccinated received their first dose before three years of age. Among children who developed autism, the mean age at diagnosis was four years and three months, while other autistic-spectrum disorders were first diagnosed at a mean age of five years and three months.

No association was detected between MMR vaccination and the development of autism or other autism-spectrum disorders. The researchers also found no association between the development of autistic disorder and the age at vaccination, time elapsed since vaccination, or time of year the vaccination was performed. After adjusting for potential confounders, such as age, sex, calendar period, socioeconomic status, birth weight, gestational age at birth, and mother's education level, only age was found to have affected the study findings.

The authors conclude that in this population-based study no association was demonstrated between MMR vaccination and later development of autism.

COPYRIGHT 2003 American Academy of Family Physicians
COPYRIGHT 2003 Gale Group

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