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Mycosis fungoides

Mycosis Fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, is a rare form of non-Hodgkin's lymphoma. It generally affects the skin, but may progress internally over time. more...

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Mycosis Fungoides was first described in 1806 by French dermatologist Jean-Louis-Marc Alibert. The name mycosis fungoides is somewhat confusing because it sounds, to the uninitiated, like a type of fungal infection. In reality, mycosis fungoides is unrelated to fungus and the fungoides portion derives from a patient with a severe case whom Alibert described as having mushroom-like skin tumors.

Origins and causes

The cause of mycosis fungoides is unknown, and is not believed to be hereditary or genetic. It is not contagious.

It is rare for the disease to appear before age 20, and it appears to be noticeably more common in males than females, especially over the age of 50, where the incidence of the disease (the risk per person in the population) does increase. The average age of onset is between 45 and 55 years of age for patients with patch and plaque disease only, but is over 60 for patients who present with tumours, erythroderma (red skin) or a leukemic form (the S├ęzary syndrome).

The disease is an unusual expression of T-cells, a part of the immune system. These T-cells are skin-associated, meaning that they biochemically and biologically are most related to the skin, in a dynamic manner. Mycosis Fungoides is the most common type of 'Cutaneous T-cell Lymphoma' (CTCL), but there are many other types of CTCL that have nothing to do with Mycosis Fungoides and these disorders are treated differently.

Symptoms, diagnosis, and stages

Typical visible symptoms include rashlike patches, tumors, or lesions. Itching (pruritus) is common, perhaps in 20% of patients, and is not universal.

Diagnosis is sometimes difficult because the early phases of the disease often resemble eczema or even psoriasis. As with any serious disease, it is advisable to pursue the opinion of a medical professional if a case is suspected. Diagnosis is generally accomplished through a skin biopsy. Several biopsies are recommended, to be more certain of the diagnosis. The diagnosis is made through a combination of the clinical picture and examination, and is confirmed by biopsy.

To stage the disease, various tests may be ordered, to assess nodes, blood and internal organs, but most patients present with disease apparently confined to the skin, as patches (flat spots) and plaques (slightly raised or 'wrinkled' spots).

Treatments and cures

Mycosis fungoides can be treated in a variety of ways.

If treatment is successful the disease can go into a non-progressing state with clinically clear examination and various tests. This is called remission; it can last indefinitely. Treatments may also cause disease not to progress, while still present, and this is called stable disease; it may last indefinitely but is a more serious situation. Disease may also progress, to involve nodes, blood and internal organs, or transform into a higher-grade lymphoma.

Read more at Wikipedia.org


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Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome (Dermatology: Clinical & Basic Science) $109.44 Mycosis Fungoides: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References $39.41
The Official Patient's Sourcebook on Mycosis Fungoides and the Sezary Syndrome: A Revised and Updated Directory for the Internet Age $32.71 A chart review of patients with early stage mycosis fungoides treated with psoralen plus UVA (PUVA). : An article from: Journal of Drugs in Dermatology $5.95
Aim for Cure in Early-Stage Mycosis Fungoides. : An article from: Skin & Allergy News $5.95 Tumor-stage MF resists stem cell treatment: treatment success in systemic non-Hodgkin's lymphoma does not translate to advanced mycosis fungoides.(Dermatologic ... : An article from: Skin & Allergy News $5.95
Cutaneous T-Cell Lymphoma (Hematology/Oncology Clinics of North America, 9:5) $32.95 Early mycosis fungoides? use older therapy. (Nitrogen Mustard). : An article from: Skin & Allergy News $5.95
Gale Encyclopedia of Cancer : Mycosis fungoides $5.99 CTCL tumor size reduced by temozolomide Tx. (Mycosis Fungoides).(cutaneous T-cell lymphoma, treatment) : An article from: Skin & Allergy News $5.95

Stem cell transplant therapy with campath-1H for treating advanced mycosis fungoides and sezary syndrome - Clinical Trial Review - Brief Article
This study is currently recruiting patients. Sponsored by National Heart, Lung, and Blood Institute (NHLB1) This study will investigate the safety ...
Mycosis fungoides: cutaneous T-cell lymphoma
Mycosis fungoides is a rare, chronic cancer of the skin that resembles several benign skin conditions (including psoriasis and allergic dermatitis) in its early stages. Mycosis fungoides is a type of
Photodynamic therapy using silicon phthalocyanine 4 in treating patients with AK, Bowen's disease, skin cancer, or stage I or stage II mycosis fungoides
This study is currently recruiting patients. Sponsors and Collaborators: Ireland Cancer Center and National Cancer Institute (NCI). This phase I trial ...
A chart review of patients with early stage mycosis fungoides treated with psoralen plus UVA
Abstract PUVA has become a common form of treatment for early stage mycosis fungoides (MF). The purpose of this retrospective study was to review the clinical data of 51 MF patients (96% stage IA
Serum protein patterns in participants with mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, or normal skin
This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI). Pilot study to evaluate the effectiveness of analyzing blood ...
Photodynamic therapy using silicon phthalocyanine 4 in treating patients with actinic keratosis, Bowen's disease, skin cancer, or stage I or stage II mycosis
This study is currently recruiting patients. Sponsors and Collaborators: Ireland Cancer Center and National Cancer Institute (NCI). This phase I trial ...
Serum protein patterns in participants with mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, or normal skin
This study is currently recruiting patients. Sponsored by National Cancer Institute (NCI) The presence of specific serum proteins may allow a doctor ...
Follicular mycosis fungoides: successful treatment with oral bexarotene
Abstract Follicular mycosis fungoides, a subtype of cutaneous T-cell lymphoma, is often difficult to treat. We present a case of a female with follicular ...

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