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Olivopontocerebellar atrophy

Olivopontocerebellar atrophy (OPCA) are a group of diseases characterized by neuronal degeneration in the cerebellum, pontine nuclei, and inferior olive. They are also referred to as spinocerebellar ataxias (SCA) or atrophies. Some also involve brain stem motor nuclei and/or cerebral cortex. All produce gait ataxia, and some also result in tremors, proprioceptive abnormalities, dysarthria, brain stem motor impairment, or dementia. Most are autosomal dominant in inheritance pattern. The primary cause of these hereditary ataxias also appears to be an unstable expansion of the polyglutamine trinucleotide repeat CAG, similar to Huntington's disease. more...

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Subcategories

Olivopontocerebellar atrophy is group of disorders which overlap certain other groups, such as spinocerebellar ataxia (SCA). Some but not all types of SCA are in the Olivopontocerebellar atrophy group. Some but not all Olivopontocerebellar atrophy conditions, are types of SCA. This situation causes some controversy and confusion about what terms and system of categorization should be used. The subcategories of Olivopontocerebellar atrophy are:

  • OPCA1
  • OPCA, Menzel type
  • Spinocerebellar ataxia type 1 (SCA1)
  • OPCA2
  • OPCA, Holguin type
  • Spinocerebellar ataxia type 2 (SCA2)
  • OPCA3
  • Spinocerebellar ataxia type 7 (SCA7)
  • OPCA with retinal degeneration
  • OPCA, Fickler-Winkler type
  • OPCA4
  • OPCA, Schut-Haymaker type
  • OPCA5
  • OPCA with dementia and extrapyramidal signs

Read more at Wikipedia.org


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The Official Patient's Sourcebook on Olivopontocerebellar Atrophy: A Revised and Updated Directory for the Internet Age $32.71 Olivopontocerebellar Atrophies: Advances in Neurology (Advances in Neurology) $72.00

Upper airway dysfunction in olivopontocerebellar atrophy
We report the findings in a patient known to have olivopontocerebellar atrophy who developed respiratory distress, inspiratory stridor, and maximum inspiratory and expiratory flow volume loops. Tr
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