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Ovarian cancer

Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries). more...

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Causes

Ovarian cancer is the fourth leading cause of cancer death in women, the leading cause of death from gynecologic malignancies and the second most commonly diagnosed gynecologic malignancy . It is idiopathic, meaning that the exact cause is unknown. The disease is more common in industrialized nations, with the exception of Japan. In the United States, females have a 1.4 % to 2.5 % (1 out of 40-60 women) lifelong chance of developing ovarian cancer.

Older women are at highest risk. More than half of the deaths from ovarian cancer occur in women between 55 and 74 years of age and approximately one quarter of ovarian cancer deaths occur in women between 35 and 54 years of age.

The risk for developing ovarian cancer appears to be affected by several factors. The more children a woman has, the lower her risk of ovarian cancer. Early age at first pregnancy, older ages of final pregnancy, and the use of some oral contraceptive pills have also been shown to have a protective effect. Ovarian cancer is reduced in women after tubal ligation.

The link to the use of fertility medication has been controversial. An analysis in 1991 raised the possibility that use of drugs tation may increase the risk for ovarian cancer. Several cohort studies and case-control studies have been conducted since then without providing conclusive evidence for such a link with the possible exception that prolonged use (> 1 year) of clomiphene citrate should be avoided.1 It will remain a complex topic to study as the infertile population differs in parity from the "normal" population.

There is good evidence that in some women genetic factors are important. Carriers of certain mutations of the BRCA1 or the BRCA2 gene (especially Ashkenazi Jewish women) are at a higher risk of both breast cancer and ovarian cancer, often at an earlier age than the general population. Patients with a personal history of breast cancer, or a family history of breast and/or ovarian cancer, may have an elevated risk. A strong family history of uterine cancer, colon cancer, or other gastrointestinal cancers may indicate the presence of a syndrome known as hereditary non-polyposis colon cancer (HNPCC), which confers a higher risk for developing ovarian cancer. Patients with strong genetic risk for ovarian cancer may consider the use of prophylactic oophorectomy after completion of child-bearing.

Other factors that have been investigated, such as talc use, asbestos exposure, high dietary fat content, and childhood mumps infection, are controversial and have not been definitively proven.

A study funded by American Cancer Society conducted at the H. Lee Moffitt Cancer Center of the University of South Florida has found a correlation between high levels of lysophospholipids (a type of fatty acid) with ovarian cancer patients and low levels of lysophospholipids with healthy women. This potential biomarker can be detected by a simple blood test. The blood test was 93 % accurate as predictor of ovarian cancer with less than 4 % false positives of the 117 women studied. Other indicators of ovarian cancer could be used to increase accuracy to 100 %. 2

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Proclamation 7919—National Ovarian Cancer Awareness Month, 2005
From Weekly Compilation of Presidential Documents, 9/5/05 by George W. Bush

August 29, 2005

By the President of the United States of America

A Proclamation

Ovarian cancer is one of the leading causes of cancer deaths among women in the United States. Each year, thousands of women are diagnosed with ovarian cancer, and thousands die from the disease. During National Ovarian Cancer Awareness Month, we strive to raise awareness of ovarian cancer and promote early detection and treatment of this disease.

Early detection is essential to the successful treatment of ovarian cancer. The 5-year survival rate is higher than 90 percent for ovarian cancer patients whose disease is caught during the first stage of development. Most ovarian cancer eases are diagnosed at an advanced stage, however, because no reliable screening test exists for the disease. Because the early signs of ovarian cancer are easy to miss and often resemble the signs of other conditions, it is important for women to talk with their doctors about detection and be aware of the risk factors and symptoms of this cancer.

There is more we need to learn about how best to prevent, detect, and treat ovarian cancer. The National Cancer Institute (NCI) is currently sponsoring a study on genetic and environmental factors that may increase the risk of ovarian cancer. In addition, the NCI is sponsoring clinical trials to explore new ways to screen for and detect ovarian cancer. Researchers are studying new treatment options, including biological therapies, anticancer drugs, vaccines, and other therapies to treat resistant forms of ovarian cancer. The Centers for Disease Control and Prevention will spend almost $4.6 million, and the Department of Defense's Ovarian Cancer Research Program will invest an estimated $10 million.

As we observe National Ovarian Cancer Awareness Month, we recognize the courage and strength of women battling ovarian cancer, and of their families and friends who love and support them. Our Nation is grateful for the hard work and commitment of our dedicated researchers and medical professionals. With continued effort, we can raise awareness of ovarian cancer and find new ways to prevent and treat this deadly disease.

Now, Therefore, I, George W. Bush, President of the United States of America, by virtue of the authority vested in me by the Constitution and laws of the United States, do hereby proclaim September 2005 as National Ovarian Cancer Awareness Month. I call upon government officials, businesses, communities, health care professionals, educators, volunteers, and all people of the United States to continue our Nation's strong commitment to preventing and treating ovarian cancer.

In Witness Whereof, I have hereunto set my hand this twenty-ninth day of August, in the year of our Lord two thousand five, and of the Independence of the United States of America the two hundred and thirtieth.

[Filed with the Office of the Federal Register, 10:36 a.m., August 30, 2005]

NOTE: This proclamation was published in the Federal Register on August 31.

COPYRIGHT 2005 U.S. Government Printing Office
COPYRIGHT 2005 Gale Group

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