Oxcarbazepinechemical structure
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Oxcarbazepine

Oxcarbazepine (Marketed as Trileptal® by Novartis) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. more...

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Oxcarbazepine is structurally a derivative of carbamazepine, adding an extra oxygen atom to the benzylcarboxamide group. This difference helps reduce the impact on the liver of metabolizing the drug, and also prevents the serious forms of anemia occasionally associated with carbamazepine. Aside from this reduction in side effects, it is thought to have the same mechanism as carbamazepine - sodium channel inhibition - and is generally used to treat the same conditions.

Side effects

Oxcarbazepine occasionally causes fatigue, nausea, vomiting, headache, dizziness, drowsiness, and blurred or double vision. It can cause hyponatremia, so blood sodium levels should be tested if the patient complains of severe fatigue.

History

First synthesized in 1966, it was approved for use as an anticonvulsant in Denmark in 1990. It was approved in all EU countries in 1999 and in the US in 2000.

Other Information

Oxcarbazapine may make cause oral hormonal contraceptives to be less effective.

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Epilepsy Rx. offered by Novartis Pharmaceuticals Corp. - Trileptal oxcarbazepine - Brief Article
From Family Pratice News, 5/1/00

Trileptal (oxcarbazepine) is indicated as adjunctive therapy or monotherapy for partial seizures in adults and as adjunctive therapy for partial seizures in children over age 4. The first antiepilepsy drug to be approved for first-line use in 5 years, Trileptal has better tolerability than older first-line medications and the most extensive long-term safety profile of newer first-line medications; it can be started at an effective dose to provide faster control of epilepsy, according to Novartis Pharmaceuticals Corp., 59 Route 10, East Hanover, NJ 07936-1080, 888-644-8585.

COPYRIGHT 2000 International Medical News Group
COPYRIGHT 2001 Gale Group

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