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Paget's disease of the breast

Paget's disease of the breast, also known as Paget's disease of the nipple, is a condition that outwardly may have the appearance of eczema - with skin changes involving the nipple of the breast. Usually only affecting one nipple, there may be redness, oozing and crusting and a sore that does not heal. more...

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Paget's disease is caused by breast cancer and is present in about 2% of all breast cancers. It typically results when malignant cells from an underlying carcinoma that originated in the ducts of the mammary glands spread to the epithelium.

Recommended tests are a mammogram and a biopsy to confirm the diagnosis.

Treatment usually involves some kind of mastectomy to surgically remove the tumour. Chemotherapy and/or radiotherapy may be necessary.

The condition is named after Sir James Paget, an English surgeon who first described it in 1874.

Read more at Wikipedia.org


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Bilateral paget disease fo the nipple associated with labular carcinoma in situ: Application of immunohistochemistry to a rare finding
From Archives of Pathology & Laboratory Medicine, 1/1/02 by Sahoo, Sunati

* We report synchronous bilateral Paget disease derived from lobular carcinoma in situ in a 53-year-old woman who underwent bilateral mastectomy. The epidermis of both nipples contained small cells with a moderate amount of pale-staining cytoplasm. The nuclei had fine chromatin and identifiable nucleoli. The cells were strongly immunoreactive with cytokeratin 7 and displayed nuclear estrogen receptor reactivity. The underlying mammary gland showed involvement by lobular carcinoma in situ with pagetoid spread into lactiferous ducts, which was confirmed by lack of immunoreactivity for E-cadherin.

(Arch Pathol Lab Med. 2002;126:90-92)

Mammary Paget disease (MPD) occurs in 1% to 4% of patients with breast cancers and is characterized by infiltration of the nipple epidermis by adenocarcinoma cells.1-3 Clinically, MPD presents as an eczematous eruption on the nipple and/or areola, often accompanied by pain or pruritus. About 10% to 28% of MPD cases are detected only by histopathologic examination of the nipple in a mastectomy specimen without apparent clinical abnormality.4 Almost all cases of MPD are associated with in situ or infiltrating ductal carcinoma of the breast. Mammary Paget disease has very rarely been associated with specialized forms of duct carcinoma (eg, papillary and medullary),' duct carcinoma arising in florid papillomatosis of the nipple and lobular carcinoma. A unique case of synchronous bilateral MPD derived from LCIS in a patient without clinical signs of Paget disease is presented.

REPORT OF A CASE

A 53-year-old woman underwent a left breast needle localization biopsy for microcalcifications in 1995. Microscopic examination of the left breast biopsy revealed benign proliferative changes, cysts, and multiple foci of atypical apocrine adenosis with microcalcifications. A single focus of atypical lobular hyperplasia was also present.

In April 2000, follow-up mammography revealed microcalcifications in the right breast for which the patient underwent a needle localization biopsy. Microscopic examination showed microinvasive ductal carcinoma and ductal carcinoma in situ (DCIS), solid type with high nuclear grade and extension into lobules. Immunohistochemical studies demonstrated membranous staining with HER-2/neu protein and nuclear reactivity with estrogen and progesterone receptor in the DCIS areas. The microinvasive carcinoma was depleted on subsequent sections and therefore was not available for hormone receptor studies. Multiple foci of LCIS and atypical duct hyperplasia were also present. Microcalcifications were noted in the proliferative changes.

In October 2000, the patient underwent bilateral mastectomies with excision of right axillary sentinel lymph nodes.

PATHOLOGIC FINDINGS

Gross examination of the right breast revealed a 20.0 x 15.0 x 3.5-cm specimen with a 17.5 X 7.0-cm elipse of skin showing a 4.5-cm linear scar in the upper outer quadrant. The cut surface of the breast parenchyma revealed fibrosis underneath the cutaneous scar. No other lesion was present. The nipple and areola skin was grossly unremarkable.

Gross examination of the left breast revealed a 20.0 x 15.0 x 3.0-cm specimen with a 20.0 x 7.0-cm elipse of skin showing a 4.0-cm linear scar in the upper outer quadrant. The nipple and areola were grossly unremarkable. Cut sections of the specimen revealed fibrous breast tissue without a distinct mass.

Microscopic sections of the right breast parenchyma showed atypical ductal hyperplasia and benign proliferative changes associated with microcalcifications.

Microscopic sections of the left breast parenchyma revealed micropapillary apocrine DCIS, widespread LCIS, apocrine adenosis, and columnar cell alteration associated with microcalcifications.

Microscopic sections from both right and left nipples showed LCIS involving lobules with pagetoid spread into lactiferous ducts. No intraductal or invasive duct carcinoma was found in either nipple. The skin of both nipples showed Paget disease characterized by the presence of single and small groups of cells with a moderate amount of pale-staining cytoplasm, nuclei with fine chromatin, and small nucleoli. These cells were similar in morphology to the LCIS in the nipple and in the breast tissue.

Immunohistochemical staining was performed to further characterize the carcinoma cells in the Paget disease using the standard avidin-biotin-peroxidase complex method (Table). The carcinoma cells within the epidermis of both nipples showed strong immunoreactivity with CK7 in a background of negatively stained keratinocytes. Immunostaining for estrogen receptor showed nuclear reactivity in the carcinoma cells. The carcinoma cells were negative for carcinoembryonic antigen and HER-2/neu. A similar pattern of staining was observed within the LCIS in nipple ducts and lobules. Lobular carcinoma in situ within the ducts and lobules of nipple showed absence of reactivity with E-cadherin. Interpretation of E-cadherin immunoreactivity was difficult around single neoplastic cells within the nipple epidermis owing to the strong membranous reactivity in the surrounding keratinocytes. However, lack of E-cadherin immunoreactivity was apparent between Paget cells in which aggregates of 2 or more carcinoma cells were present. The in situ carcinoma in the nipple and left breast are depicted in Figure 1, and the nipple skin lesion is shown in Figure 2.

COMMENT

Bilateral breast carcinoma is reported to occur in 5% to 10% of all patients with breast cancer.6 However, synchronous bilateral Paget disease of the nipple is extremely rare.7-9 This report describes a unique case of synchronous bilateral Paget disease of the nipple derived from LCIS, which involved underlying lactiferous ducts and lobules in the nipple.

Mammary Paget disease represents the spread of carcinoma cells into the epidermis of the nipple and areola from an underlying mammary adenocarcinoma in almost every case. In more than 95% of cases of Paget disease, an associated carcinoma is detected in the breast and/or the nipple. These masses have virtually all been duct carcinomas, with or without an invasive component. In most cases, the lactiferous ducts directly connected to the Paget disease contain comedocarcinoma.10 Ductal carcinoma in situ associated with Paget disease characteristically has a comedo or solid growth pattern. Cribriform and papillary carcinomas are found in about 10% of cases, and about 40% of cases have mixed types of DCIS.11 Chaudary et ahz reported DCIS beyond the subareolar area in 25 (78%) of 32 mastectomy specimens associated with Paget disease. In a series of 204 cases of Paget disease of nipple studied by Ashikari et al,' 4 were associated with LCIS and 2 with infiltrating lobular carcinoma.

Lobules may be present normally in the nipple and they can be the substrate for LCIS. Rosen and Tench 13 reported lobules within the nipple in 17 of 101 consecutive mastectomy specimens. Carcinoma was found in 13 nipples, and Paget disease was present in 3 nipples associated with intraductal and invasive ductal carcinomas.13

In the current case, the left breast contained 1 focus of DCIS in the upper outer quadrant, and the right breast had DCIS and microinvasive duct carcinoma in the upper outer quadrant. No intraductal or invasive duct carcinoma was present in either carefully sampled nipple. However, both nipples had multiple lobules, many of which were involved by LCIS with pagetoid spread into lactiferous ducts. The cytomorphology of the Paget cells, absence of DCIS in the nipples, involvement of the lactiferous ducts by LCIS, and absence of HER-2/neu and E-cadherin staining strongly support the conclusion that bilateral Paget disease derived from LCIS in this instance.

References

1. Ashikari R, Park K, Huvos AG, Urban JA. Paget's disease of the breast. Cancer. 1970;26:361-365.

2. du Toit RS, van Rensburg PSJ, Goedhals L. Paget's disease of the breast. S Afr Med J. 1988;73:95-97.

3. Kister SJ, Haagensen CD. Paget's disease of the breast. Am J Surg. 1970; 119:606-609.

4. Mendez-Fernandez MA, Henly WS, Geis RC, Schoen Fl, Hausner RJ. Paget's disease of the breast after subcutaneous mastectomy and reconstruction with a silicone prosthesis. Plast Reconstr Surg. 1980;65:683-685.

5. Rosen PP, Caicco J. Florid papillomatosis of the nipple: a study of 51 patients including nine having mammary carcinoma. AmI Surg Pathol. 1986;10:87-101. 6. Gogas J, Markopoulos C, Skandalakis P, Gogas H. Bilateral breast cancer. Am Surg. 1993;59:733.

7. Anderson WR. Bilateral Paget's disease of the nipple: case report. Am J Obstet Gynecol. 1979;134:877-878.

8. Markopoulos C, Gogas H, Sampalis F, Kyriakou B. Bilateral Paget's disease of the breast. EurJ Gynaecol Oncol. 1997;18:495-496.

9. Fernandes F, Costa M, Bernardo M. Bilateral Paget's disease of the breast: a case report. Eur/ Surg Oncol. 1990;16:172.

10. Rosen PP. Paget's disease of the nipple. In: Rosen PP, ed. Rosen's Breast Pathology. Philadelphia, Pa: Lippincott-Raven; 1996:493-506.

11. Veilh P, Validire P, Kheirallah S, Kampana F, Fourquet A, Di Bonito L. Paget's disease of the nipple without clinically and radiologically detectable breast tumor: histochemical and immunohistochemical study of 44 cases. Pathol Res Pract. 1993;189:150-155.

12. Chaudary MA, Millis RR, Lane EB, Miller NA. Paget's disease of the nipple: a ten-year review including clinical, pathological and immunohistochemical findings. Breast Cancer Res Treat. 1986;8:139-146.

13. Rosen PP, Tench W. Lobules in the nipple: frequency and significance for breast cancer treatment. Pathol Annu. 1985;20:317-322.

Sunati Sahoo, MD; Ileana Green, MD; Paul P. Rosen, MD

Accepted for publication July 2, 2001.

From the Department of Pathology, New York Presbyterian HospitalWeill Cornell Medical Center, New York, NY (Drs Sahoo and Rosen); and the Department of Pathology, Lenox Hill Hospital, New York, NY (Dr Green).

Reprints: Paul P. Rosen, MD, Breast Pathology Consultation Service, Department of Pathology, New York Presbyterian Hospital-Weill Cornell Medical Center, 525 E 68th St, Starr 1031, New York, NY 10021.

Copyright College of American Pathologists Jan 2002
Provided by ProQuest Information and Learning Company. All rights Reserved

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