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Panniculitis

Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous fatty and muscle tissue. Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.

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ERYTHEMA INDURATUM OF BAZIN AND RENAL TUBERCULOSIS: REPORT OF AN ASSOCIATION
From Revista do Instituto de Medicina Tropical de Sao Paulo, 9/1/04 by De Francesco Daher, Elizabeth

SUMMARY

Erythema induratum of Bazin is a disease that usually affects women, in whom erythematous subcutaneous nodules and plaques appear on the posterior part of the lower extremities, some of which ulcerate. In many countries, tuberculosis is still the main etiologic factor. We report a case of a 40-year-old woman who presented a course of protracted and recurrent episodes over five years of cutaneous lesions on her legs. These tend to involute, but new crops appear at irregular intervals. It was painful, erythematous-violaceous nodules, some of which drained a reddish secretion. The histopathologic features of the lesions demonstrated inflammatory infiltration, with predominance of neutrophils in dcrmis and hypodermis, nccrotizing vasculitis in the arterioles and septal fibrosis. There was no granuloma. The Ziehl-Neelsen stain did not revealed acid-fast bacilli, and the culture of biopsy specimen was negative. The tuberculin skin test was strongly positive (17 mm). The chest X-ray was normal. Few months later she presented adynamia and urinary complaints, such as polacyuria and dysuria. It has been done an urynalysis, which demonstrated acid pH urine, sterile pyuria and microscopic hematuria. It was then raised the diagnostic hypothesis of renal tuberculosis. The urine culture for M. tuberculosis was positive in two out of ten samples. The treatment was instituted with rifampin, isoniazid and pyrazinamide, with complete regression. This case illustrates a clear association between erythema induratum and renal tuberculosis, demonstrated by the remission of the cutaneous lesions after the treatment of the renal tuberculosis.

KEYWORDS: Erythema induratum of Bazin; Renal tuberculosis; Cutaneous tuberculosis; Vasculitis.

INTRODUCTION

Erythema induratum of Bazin (EIB) is a chronic nodular eruption that usually occurs on the legs of teenage and middle-aged women5,15,20. It was first described by Bazin in 1861, and French dermatologists linked this condition to tuberculosis in 1900(5). The Mycobacterium tuberculosis has been hardly detected in the cutaneous lesions, so that this association has been refuted for a long time5,14,22. Many recent studies have found genetic material of M. tuberculosis by polymerase chain reaction (PCR) in the samples of cutaneous lesions, suggesting the tuberculous etiology of BIB2,6,11,12,24,26,29.

The disease is characterized by a recurrent pattern, with painful, deep-seated, subcutaneous induration, which gradually extends to the skin surface forming bluish-red nodules or plaques which often ulcerate12. The most frequent sites in which the lesions occur are the shins and calves of the lower legs, but they can also occur on the feet, thighs, arms and face12. The presentation is usually bilateral and can spontaneously heal, with atrophic hyperpigmented scars18.

The histopathologic picture of EIB is characterized by a granulomatous, tubcrculoid infiltrate, vascular changes, and areas of caseation necrosis5. There is granulomatous infiltration of the subcutis, nccrotizing vasculitis with mural thickening of subcutaneous arteries and veins, and pcrivascular cuffing18,20. Areas of fat necrosis are prominent, and foreign-body giant cells and granulomas can be found18. Caseation is rare in most reports, and acid-fast bacilli are usually absent. SCHNEIDER & JORDAAN25 studied a group of patients with EIB and divided them into two major histopathologic groups: one presented septolobular panniculitis in close association with a single muscular artery or small vessel with primary neutrophilic vasculitis, while the other one showed diffuse septolobular panniculitis with primary neutrophilic vasculitis of either large or smaller vessels. It was found in both groups varying combinations and degrees of acute and chronic inflammation, coagulative and caseation-like necrosis, and granulomatous inflammation, demonstrating the histopathologic heterogeneous spectrum that can be found in EIB.

The EIB is believed to be an example of tuberculid, which comprises a group of eruptions that arise in response to an internal focus of tuberculosis and is regarded as a hypersensitivity reaction to M. tuberculosis5. Some authors have found pulmonary tuberculosis in patients with BIB5,12. Other latent foci of internal tuberculosis can be detected in these patients, so an association between renal tuberculosis and EIB had been described one time before by FERNANDEZ del MORAL et al.8.

After the informed consent of the patient, we report a case ofa woman in whom a renal tuberculosis was diagnosed after a long period presenting symptoms of EIB.

CASE REPORT

A 40-year-old woman from the countryside of Ceará, northeast of Hrazil. had complaints of cutaneous lesions on her legs for five years. She had painful, erythemato-violaccous nodules, some of them ulcerated and draining a reddish secretion (Fig. 1). The lesions used to heal spontaneously and reappeared every month. In her past history, the only remarkable disease was syphilis, ten years ago, and was successfully treated with antibiotics. It has been done biopsy of one of the cutaneous lesions, which demonstrated inflammatory infiltration, with predominance of ncutrophils in dermis and hypodermis, vasculitis in the arterioles and septal fibrosis. There was no granuloma. The ZiehlNeelsen stained sections did not revealed acid-fast bacilli, and the culture of biopsy specimen was negative. The tuberculin skin test (PPD) was positive, demonstrating a reaction of 17 mm. The chest X-ray was normal.

Few months later she presented adynamia and urinary complaints, such as polacyuria and dysuria. She had no fever or other symptoms. The urynalysis showed an acid urine (pH = 5.5), sterile pyuria and microscopic hematuria (6 erythrocytes per high power field). The quantification of pyuria and hematuria through the method of Addis demonstrated the presence of more than 1,600,000 erythrocytes (reference value:

The treatment, was instituted with anlituberculous drugs (rifampin 600 mg/day, isoniazid - 200 mg/day and pyrazinamide - 2 g/day for two months, and rifampin plus isoniazid for four months), after which she presented a great improvement. Two months after the beginning of the treatment, the cutaneous lesions and the urinary symptoms had disappeared. During her follow-up (three months after the end of the treatment) it was recorded no relapse of the skin lesions or signals of renal disease.

DISCUSSION

Erythema induratum of Bazin (EIB) is characterized by chronic, tender, erythemato-violaceous, indurated and often ulcerative subcutaneous nodules on the lower extremities of women with tuberculin hypersensitivity5,24. All this was seen in our patient, which presented these classical skin lesions, with a recurrent pattern since five years ago.

The diagnosis of HIB can be made through suggestive clinical and histopalhological features, positive epidemiology for tuberculosis, positive PPD test and response to the treatment with tuberculostatics21. In our case, the diagnosis was possible analyzing the clinical pattern of the cutaneous lesions, the histopathological features and the strongly positive PPD test, all suggestive of erythema induratum. The appearance of urinary symptoms raised the suspicion of associated renal tuberculosis, which could be the focus responsible for the development of cutaneous involvement. KRAEMER et al.13 reported a case of a young woman who developed skin lesions on her legs similar to those seen in this patient, with no evidence of renal tuberculous infection. LAFUENTEURREZ et al.15 described a similar case. In both, the tuberculin skin test was strongly positive, suggesting a strong correlation of the erythema induratum with tuberculosis.

It is still not known the exact pathogenesis of EIB. It is not clear if it is a true tuberculosis with viable organisms in the lesions, coming through hematogenous spread to the skin from a distant latent focus elsewhere in the body12,24. It is believed that EIB represent a hypersensitivity reaction, type III or IV (tubcrculid), to M. tuberculosis antigens in patients with a high degree of tuberculin hypersensitivity5,24. The histopathologic features are heterogeneous and include necrotizing vasculitis, granulomatous infiltration, with caseation necrosis5,17,20,28. The detection of the bacilli through PCR technique strongly suggests the tuberculous etiology of this disease2,6,11,12,24,26,29. The PCR has a sensitivity of 98% and specificity of 100%, being an excellent method for the diagnosis of EIB, but has the disadvantage of being expensive21. The EIB is also called nodular vasculitis18. The deposition of immune complex in the vessel walls has been described as responsible for nodular vasculitis, but it has not been found immunedcposils or complement in the skin lesions of EIB. The term EIB should be reserved lor those cases of nodular vasculitis in which components of tubercle bacilli are causative14.

The association between EIB and focus of tuberculosis, in the lungs, pleura, pericardium, peritoneum, lymph nodes and endometrium, has been described in the medical literature5,8,9,10,12,16,27. It is estimated that, in 25 to 70% of the patients with RIB, M. tuberculosis can be found in the skin lesions through the PCR. In the remaining patients, the disease is considered to be idiopathic4. In most cases, the EIB occurs without demonstrable focus of tuberculous infection, being the tuberculous etiology suggested by a positive PPD7,19. The case presented here shows a clear association between EIB and renal tuberculosis, with the later being diagnosed some years after the beginning of the cutaneous lesions. In the female patient described by FERNANDEZ del MORAL et al.8 the renal tuberculosis was diagnosed seven years after the beginning of the symptoms of erythema induralum. In the case presented here the interval between the appearance of urinary symptoms and the skin lesions was five years, demonstrating the latent pattern of the renal tuberculosis. The diagnosis was confirmed, in both cases, through a positive urine culture for M. tuberculosis.

Tuberculosis can cause two forms of renal disease, which are direct infection or secondary amyloidosis23. Renal tuberculosis, the third more frequent kind of cxirapulmonary tuberculosis', is a common missed genitourinary infection that should be considered in any case of urinary symptoms, like pyuria or hemaluria. which do not respond to common antibacterial drugs30. This condition is always secondary to a pulmonary infection, though in the majority of cases this primary focus has healed or is quiescent. The bacilli can reach other organs, including the kidneys, via the hemalogenous route30.

The onset of clinically evident genitourinary tuberculosis is often insidious, with dysuria and gross hematuria being the most common symptoms'. The time between the infection and the appearance of symptoms can reach as far as twenty years'. Some patients are asymptomatic, being pyuria and/or microscopic hematuria found incidentally. These two abnormalities are present in more than 90% of cases21. Our patient presented no evidence of pulmonary infection and developed urinary symptoms after the appearance of skin lesions suggestive of erythema induralum. These two conditions together strongly suggested the etiology of the cutaneous and renal disease as being tuberculosis.

The diagnosis of renal tuberculosis is difficult, because it is hard to identify the organisms in the urine. BENNANI el al.3 studying 109 cases of renal tuberculosis, have found bacilli in the urine of 41 patients (38%). This is comprehensible because bacilli are shed into the urine intermittently, resulting in only 30 to 40% of single urine specimens to be positive in patients with active disease23. The urine is classically sterile by routine culture, with concurrent bactcriuria occurring in some cases. The urinary pll is usually acid, which is an important feature to differentiate from the common urinary infections'. The find of dysuria, sterile pyuria, hematuria and characteristic radiological features are highly suggestive of renal tuberculosis, but it has to be confirmed through urine culture, which is the gold standard method for establishing the diagnosis23. However, the finding of acid-fast bacilli in the urine with a Ziehl-Neelsen stain or fluorescent dye techniques is not pathognomonic for this disorder, since nonpathogenic mycobacleria may occasionally be present21. In the case presented here, M. tuberculosis has not been found through acidfast bacilli staining. The diagnosis was confirmed only alter ten sequential urine cultures.

Intravenous urography can also be used in the investigation of renal tuberculosis, which can shows characteristic signs, mainly in the ureter or the piclocalycial region3,30. It can be seen erosion of the tips of the calyces, blunting of the calyces or overt papillary necrosis, and parenchymal scarring and calcification. In the present case, the radiologie findings did not demonstrate any significant abnormality.

The treatment of both HIB and renal tuberculosis consists in antitubcrculous drugs (rifampin, isoniazid and pyrazinamide). It led to the resolution of the skin lesions and urinary symptoms of our patient. The favorable response to these drugs can be used to confirm the tuberculous etiology of the EIB. In all the cases reported before the patients presented a great improvement after the administration of antitubcrculous agents, and there was no evidence of recurrence after the correct treatment8,12,13,15. Relapses occur only when the therapy is inadequate, with the use of only two drugs or short period of antituberculous treatment (less than 9 months) or in the cases with drugresistant bacilli9,22. In the case of renal tuberculosis, antitubcrculous agents are successful in eradicating active infection in almost all patients. Ureteral strictures may progress during treatment due to scarring and subsequent narrowing of the lumen. It is recommended to perform intravenous urography or renal ultrasound every six months for the first two years in patients with urcteral strictures to detect possible urinary tract obstruction23.

In summary, this case illustrates a rare form of cutaneous tuberculosis (erythema induratum) associated with renal tuberculosis, a urinary infection commonly missed in the clinical practice. The key points in the diagnosis of EIB are the clinical and histological characteristics of the skin lesions, mainly on the legs, the classical recurrent pattern of presentation, the strongly positive tuberculin skin test, the possible evidence of tuberculosis elsewhere in the body and the good response to the treatment with antitubcrculous drugs. Renal tuberculosis is hard to diagnose and should always be investigated in a patient with EIB.

RESUMO

Eritema indurado de Bazin c tuberculose renal: relate de uma associação

O critcma indurado de Bazin é docnça caracterizada por crupçocs cutâncas que usualmente ocorrem nos mcmbros inferiores de mulhcrcs adolescentes e de meia idade. Rclatamos o caso de paciente de 40 anos que aprcscntava há 5 anos lesõcs cutâneas em região inferior de ambas as pcmas. Tratavam-sc de nodulos critemato-violâceos, dolorosos, alguns dos quais drenavam secreçâo scrossangufnca. O cxame histopatologico da biopsia de pelé dcmonstrou infiltrado inflamatorio, com predomfnio de neutrofilos na derme e hipoderme, vasculitc nécrosante em arterfolas e fibróse scptal. NSo foram identificados granulomas. A coloraçâo dc Zichl-Ncelsen não rcvclou bacilos álcool-ncido rcsistcntes, c a cultura do material biopsiado foi ncgativa. O PPD foi fortementc reator (17 mm). O raio-X de torax era normal. Alguns meses depois, a paciente evoluiu com adinamia c sintomas urinários, como polaciuria e disuria. O cxamc dc urina mostrou urina ácida, piuria estiril e hcmaturia. Foi levantada a hipótese de tuberculose renal. A urinocultura foi positiva para M. tuberculosis em duas amostras de dez solicitadas. O tratamento foi instituído com rifampicina, isoniazida e pirazinamida, com melhora considerável do quadro. Este caso ilustra uma associaçâo clara entre o critema indurado e a tuberculose renal, dcmonstrada através da remissão das lesões cutâneas após ? tratamento da tuberculose renal.

REFERENCES

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2. ARORA, S.K.; KUMAR, B. & SEHGAL, S. - Development of a polymcrase chain reaction dot-blotting system for detecting cutaneous tuberculosis. Brit. J. Derm., 142: 7276, 2000.

3. BENNANI, S.; FEKAK, H.: HAFIANI, A. el al. - La tuberculose urogenitale. À propos de 109 cas. Me(I. Mal. infect., 29: 19-25. 1999.

4. BOLOGNIA, J.L. & BRAVERMAN, LM. - Manifeslaçõcs culâncas de docnças internas. In: BRAUNWALD, E.; FAUCI, A.S.; KASFER, D.L. et al., ed. Harrison Mcdicina interna. 15. ed. Rio de Janeiro, McGraw-Hill, 2002. p. 347-348.

5. CHO, K.H.; LEi;, D. Y. & KIM, C.W. - Erythema induratum of Bazin. Int. J. Derm., 35: 802-808, 1996.

6. DIAZ, C.; CUCURRELL, M.; JEREMIAS, J. cl al. - Tuberculosis verrucosa cutis, erythema induratum and PCR. J. Europ. Acad. Denn. Vener., 9 (suppl. 1): S129, 1997.

7. FFIWEL, M. & MUNRO, D.D. - Diagnosis and treatment of erythema induratum (Bazin). Brit. med. .1., 5442: 1109-1111, 1965.

S. FERNANDEZ del MORAL. R.; ERENO. C.; ARRINDA, J.M. & ALVAREZ DE MON, M. - Erythema induratum of Bazin and active renal tuberculosis. J. Amer. Acad. Derm., 31: 288-290, 1994.

9. FÖRSTRÖM, L. & HANNUKSIiLA, M. - AntiUiberculous treatment of erythema intluralum of Bazin. Acta derm.-venercol. (Stockh.), 50: 143-147, 1970.

10. HASSOUN, P.M.; SHKPHKRD, K.K.; KLOTTK, TJ. & KAZFMl, H. - Erythema induratum and active pulmonary tuberculosis. Amcr. J. Med., 84: 784-785, 1988.

11. HKlNFMANN, C.; KAAT/, M. & ELSNFR, P, - Erythema induratum of Bazin and Poncct's disease: successful treatment with antitubcrcular drugs, J. Europ. Acad. Derm. Vcncr., 17: 334-336, 2003.

12. JACINTO, S.S. & NOGRALKS. K.B. - Erythema induratum of Bazin: role of polymcrase chain reaction in diagnosis. InI. J. Derm., 42: 380-381, 2003,

13. KRAEMKR, C.K.; SILVKIRA, C.M.; RUTHNKR, KG. & GARCIA, C.R. - Eritema imlurado de Bazin. J. bras. Mcd., 83: 68-69, 2002.

14. KURAMOTO. Y. AIBA. S. & TAGAMI, H. - Erythema induralum of Bazin as a type of (ubcrculid, .J. Amer. Acad. Derm., 22: 612-616, 1990.

15. LAFUENTE-URREZ, R.K; DACHARY-PAGOLA, M.T. & RUIZ-LAIGLESIA, F. Lesioncs nodulares en extrcmidadcs inferiores de larga evokicion. Eritema indurado de Bazin [Letter]. An. Mcd. interna (Madrid), 20: 498, 2003.

16. LEBEL, M. & LASSONDE, M. - Erythema induratum of Bazin. J. Amer. Acad. Derm., 14: 738-742, 1986.

17. MACEIRA, J.M.P.; FUKUYAMA, K.; EPSTEIN, W.L. & ROWDEN, G. - Immunohistochemical demonstration of S-100 protein antigen-containing cells in beryllium-induced, zirconium-induced and sarcoidosis granulomas. Amer. J. clin. Path., 81: 563-568, 1984.

18. MacGREGOR, R.R. - Cutaneous tuberculosis. Clin. Demi., 13: 245-255, 1995.

19. MICHELSON, H.E. - Inflammatory nodosa lesions of the lower leg. Arch. Derm. Syph. (Chic.), 66: 327-332, 1952.

20. MURPHY, G.F. & MIHM-Jr., M.C. - A pele. In: COTRAN, R.S.; KUMAR, V.; ROBBINS, S.L. & SCHOEN, FJ., ed. Rohbins Patologia cstrutural e funcional. 5. ed. Rio de Janeiro, Guanabara-Koogan, 1996. p. 1058-1093.

21. NASCIMENTO, L.V.; RODRIGUES, A.C.; CARNEIRO, M.B.X. et al. - Tuberculose cutânea no Brasil. An. bras. Denn., 71: 21-24, 1996.

22. RADEMAKER, M.; LOWE, D.G. & MUNRO, D.D. - Erythema induratum (Bazin's disease). .1. Amer. Acad. Derm., 21: 740-745, 1989.

23. ROSE, B.D. - Renal disease in tuberculosis. UpToDate, 2002. In: http://www.uptodate.com.

24. SCHNEIDER, J.W.; GEIGER, D.H.; ROSSOUW, D.J. et al. - Mycobaclerium tuberculosis DNA in erythema induratum of Bazin [Letter]. Lancet, 342: 747-748, 1993.

25. SCHNEIDER, J.W. & JORDAAN, H.F. - The histopathologic spectrum of erythema induralum of Bazin. Amer. J. Dcrmatopath., 19: 323-333, 1997.

26. SECKIN, D.; HIZEL, N. & DEMIRHAN, B. - Erythema induratum of Bazin: identification of mycobaclerium tuberculosis DNA by the polymerase chain reaction. J. Europ. i Acad. Derm. Vcner., 9 (suppl. 1): S193, 1997.

27. SILVA, HJ.; GOONETILLEKE, A.K.E.; SILVA, N.R.; AMARASEKERA, L.R. & JAYAWICKRAMA, U.S. - Erythema induratum (of Bazin) in a patient with endometriai tuberculosis. Postgrad, med. J., 64: 242-244, 1988.

28. SMOLLE, J. - T-zone histiocytes in granulomatous skin diseases. Dcrmatologica (Basel), 171: 316-320, 1985.

29. TAN, S.H.; TAN, B.H.; GOH, C.L. et al. - Detection of Mycobaclerium tuberculosis DNA using polymerase chain reaction in cutaneous tuberculosis and tuberculids. j Int. J. Derm., 38: 122-127, 1999.

30. WILLIAMS, R.D.; COOPER, C.S. & DONOVAN-Jr., J.F. - Urology. In: WAY, L.W. & DOHERTY, G.M., cd. Current surgical diagnosis and treatment. 11. ed. New York, McGraw-Hill, 2003. p.1013-1084.

Received: 9 June 2004

Accepted: 27 September 2004

Elizabeth De Francesco DAHER(1,2), Geraldo Bczcrra da SILVA JUNIOR(I), Hugo César Furtado PINHEIRO(1), Talianc Roseno de OLIVEIRA(1), Maria do Livramento Lcitão VILAR(1) & Karlla Jordão de ALCÂNTARA(1)

(1) Services de Derniatologia e Nefrologia, Hospital Universitario Walter Cantídio, Departamento de Medicina Clínica, Faculdade de Medicina, Univcrsidade Federal do Ceará, Fortalexa, CE, Brasil.

(2) ,Service de Nefrologia, Hospital Geral de Forlaleza, Seeretaria de Saúde do listado do Ceará, Forlaleza, CF, Brasil.

Correspondence to: Elizabeth De Francesco Daher, Rua Vicente Linhares 1198, 60270-135 Fortaleza, CF, Brasil. Phone/Fax: 55.85.2249725/55.85.2613777. E-mail: efdahcr@for.terra.com.br

Copyright Instituto de Medicina Tropical de Sao Paulo Sep/Oct 2004
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