Pleural effusion Chest x-ray of a pleural effusion. The arrow A shows fluid layering in the right pleural cavity. The B arrow shows the width of the lung
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Pleural effusion

Pleural effusion is a medical condition where fluid accumulates in the pleural cavity which surrounds the lungs, making it hard to breathe. more...

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Four main types of fluids can accumulate in the pleural space:

  • Serous fluid (hydrothorax)
  • Blood (hemothorax)
  • Lipid (chylothorax)
  • Pus (pyothorax or empyema)

Causes

Pleural effusion can result from reasons such as:

  • Cancer, including lung cancer or breast cancer
  • Infection such as pneumonia or tuberculosis
  • Autoimmune disease such as lupus erythematosus
  • Heart failure
  • Bleeding, often due to chest trauma (hemothorax)
  • Low oncotic pressure of the blood plasma
  • lymphatic obstruction
  • Accidental infusion of fluids

Congestive heart failure, bacterial pneumonia and lung cancer constitute the vast majority of causes in the developed countries, although tuberculosis is a common cause in the developing world.

Diagnosis

In states of excess accumulation, pleural fluid can be sampled and evaluated to determine what disease state may be causing it. This can be sampled through a thoracentesis, where a needle is inserted through the back of the chest wall and into the pleural space. The evaluation consists of:

  1. Gram stain and culture - identifies bacterial infections
  2. Cell count and differential - differentiates exudative from transudative effusions
  3. Cytology - identifies cancer cells, may also identify some infective organisms
  4. Chemical composition including protein, lactate dehydrogenase, amylase, pH and glucose - differentiates exudative from transudative effusions
  5. Other tests as suggested by the clinical situation - lipids, fungal culture, viral culture, specific immunoglobulins

Read more at Wikipedia.org


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Single center experience with 250 tunnelled pleural catheter insertions for malignant pleural effusion
From CHEST, 10/1/05 by Alain Tremblay

PURPOSE: To describe the use of tunneled pleural catheter in the management of malignant pleural effusion in a large group of patients in a clinical setting.

METHODS: Retrospective analysis of 250 sequential tunneled pleura/ catheter insertions in patients with malignant pleural effusion in a single tertiary care center.

RESULTS: 250 tunneled pleural catheter procedures for malignant pleural effusion were performed in 223 patients (19 contralateral procedures and 8 repeat ipsilateral procedures) during a 3 year period. Symptom control was complete following 97 (38.8%) procedures, partial in 125 (50%), absent in 8 (3.2%) in addition to 11 (4.4%) failed insertions and 9 (3.6%) without assessment of symptoms at the 2 week follow-up visit. Spontaneous pleurodesis occurred following 103 (42.9%) of the 240 successful tunneled pleural catheter procedures and was more frequent when 20% or less of the hemithorax had fluid at 2 week follow-up (57.2% vs. 25.3%, p<0.001). Catheters stayed in place for a median of 56 days. Following successful catheter placement, no further ipsilateral pleural procedures were required in 90.1% of cases. Overall median survival following catheter insertion was 144 days. Complication rates were low and compared favourably with those seen with other treatment options.

CONCLUSION: Tunneled pleural catheter placement is an effective method of palliation for malignant pleural effusion which allows outpatient management and low complication rates. Tunneled pleural catheters should be considered as a first line treatment option in me management of malignant pleural effusion.

CLINICAL IMPLICATIONS: The use of tunneled pleural catheters for malignant pleural effusion is safe, simple and effective and should be considered in the palliation of this patient group.

DISCLOSURE: Gaetane Michaud, Consultant fee, speaker bureau, advisory committee, etc. Dr. Michaud received an honorarium from Denver Biomedical for speaking at the Societe des pneumonlogues de la langue francaise about the use of the Pleurx catheter for malignant pleural effusions.

Alain Tremblay MD Gaetane C. Michaud MD * University of Calgary, Calgary, AB, Canada

COPYRIGHT 2005 American College of Chest Physicians
COPYRIGHT 2005 Gale Group

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