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Silver-Russell dwarfism

Silver-Russell dwarfism, also called Silver-Russell syndrome (SRS) or Russell-Silver syndrome (RSS) is a growth disorder occurring in approximately 1/75000 births. It is a genetic anomaly, and there are no tests to determine if this is what a child has. Symptoms are Intrauterine_Growth_Restriction (IUGR) combined with some of the following: more...

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  • Often a diagnosis of Small for Gestation Age (SGA) at birth.
  • Feeding problems, the baby is uninterested in feeding and takes only small amounts with difficulty.
  • Excessive sweating as a baby, especially at night, and a greyness or pallor of the skin. This may be a symptom of low blood sugar in the blood (hypoglycemia).
  • Triangular shaped face with a small jaw and a pointed chin. The mouth tends to curve down.
  • A blue tinge to the whites of the eyes in younger children.
  • Head appears large - the head circumference may be of normal size which means it can appear large in comparison to a small body size.
  • Wide and late closing fontanelle.
  • Clinodactyly, the little finger on each hand may be small and curve inwards.
  • Body asymmetry, one side of the body grows more slowly than the other.
  • Continued poor growth with no "catch up" into the normal centile lines on growth chart
  • Precocious puberty (occasionally).
  • Gastroesophogeal Reflux.

Growth hormone therapy is sometimes used to aid growth, as SRS can cause growth hormone deficiency.

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