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Suxamethonium chloride

Suxamethonium chloride (also known as succinylcholine, or scoline) is a white crystalline substance, it is odourless and highly soluble in water. The compound consists of two acetylcholine molecules that are linked by their acetyl groups. Suxamethonium is sold under several trademark names such as Anectine®. more...

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Suxamethonium acts as a depolarizing muscle relaxant. It imitates the action of acetylcholine at the neuromuscular junction, but it is not degraded by acetylcholinesterase but by pseudocholinesterase, a plasma cholinesterase. This hydrolysis by pseudocholinesterase is much slower than that of acetylcholine by acetylcholinesterase. The prolonged stimulation of the acetylcholine receptor results first in disorganized muscle contractions (fasciculations, considered to be a side effect as mentioned below), then in profound relaxation.

Its medical uses are limited to short-term muscle relaxation in anesthesia and intensive care, usually for facilitation of endotracheal intubation. Despite its many undesired effects on the circulatory system and skeletal muscles (including malignant hyperthermia, a rare but life-threatening disease), it is still much used because it arguably has the fastest onset of action of all muscle relaxants.

A single intravenous dose of 0.6 to 1.0 milligrams per kilogram of body weight will cause flaccid paralysis within a minute of injection. For intramuscular injection higher doses are used and the effects last somewhat longer. Suxamethonium is quickly degraded by plasma cholinesterase and the duration of effect is usually in the range of a few minutes. When plasma levels of cholinesterase are greatly diminished or an atypical form of cholinesterase is present (an otherwise harmless inherited disorder), paralysis may last much longer.

Side effects include fasciculations, acute rhabdomyolysis with hyperkalemia, transient ocular hypertension, and changes in cardiac rhythm including bradycardia, cardiac arrest, and ventricular dysrhythmias. In children with unrecognized neuromuscular diseases, a single injection of succinylcholine can lead to massive release of potassium from skeletal muscles with cardiac arrest.

The ability to paralyze the respiratory muscles have led to its use as part of a lethal injection.

Read more at Wikipedia.org


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US conference looks at improving patient safety
From British Medical Journal, 5/8/99 by Norra MacReady

Dr Richard Cook, an anaesthetist at the University of Chicago, works daily with the most advanced equipment available. Yet he keeps several syringes nearby, filled either with succinylcholine (suxamethonium chloride) or thiopental (thiopentone). "The world isn't always a perfect place," he explained. When disaster looms, "you need a path of retreat, a way to back away." The importance of finding simple alternatives to complex equipment was one of the recommendations Cook made last week at the Southern California Patient Safety forum held in Los Angeles.

Traditional approaches to disaster management tell us nothing about how accidents actually happen, Cook said. Defining an accident as "an incident with bad consequences," he explained that accidents occur in complex systems such as hospitals because of the combination of multiple small failures, each insufficient in itself to cause a disaster.

Conventional disaster management, however, assumes that accidents result from single point failures, and the conventional response in medicine is to "blame and train": installing automated systems that are even more complex and therefore more prone to error; instituting ever more restrictive rules and policies; and imposing stiffer sanctions on the individual blamed for the disaster of the day. He also pointed out that "talking about safety is not safe," because it is more politically correct to appear to be safe than to have an honest discussion about a system's shortcomings and the trade offs required to increase safety.

Also speaking at the conference was Dr Karlene Roberts of the University of California, Berkeley. She heads a group of investigators who have been examining organisations in which error can have camstrophic consequences, including intensive care units in hospitals, commercial airlines, hostage and terrorist negotiation units in the United States and France, and community emergency services (police, fire, and emergency medicine) in the United States and the United Kingdom.

Roberts and her team have identified five ingredients necessary for patient safety: an established system of ongoing checks and balances designed to spot risk and identify safety problems; appropriate rewards for workers who identify possible safety risks, including mistakes they themselves have made; a system of quality control; the perception and acknowledgement of risk by the organisation; and a system of command and control that permits decisions to be made by the people with the most experience, even if they are of lower rank than others on their team.

Roberts encouraged her listeners to ask themselves if their organisations had all of these characteristics. "If [the organisation] doesn't, it is probably risk prone. And the costs of being risk prone are always ultimately higher than the costs of prevention."

Norra MacReady, Los Angeles

COPYRIGHT 1999 British Medical Association
COPYRIGHT 2000 Gale Group

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