Terbutaline chemical structure
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Terbutaline

The drug Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator and as a tocolytic to delay premature labour.

Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. Recent studies have suggested that terbutaline is a developmental neurotoxicant and may cause brain damage to the infant. (J Pharmacol Exp Ther. 2004 Feb;308(2):529-37. Epub 2003 Nov 10.)

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Infuse Terbutaline to prolong Triplet gestations - Continuous Drug Delivery
From OB/GYN News, 1/15/02 by Jeff Evans

Triplet pregnancy can be prolonged for a longer period with continuous subcutaneous terbutaline infusion than with oral terbutaline, said Dr. John P. Elliott of the Good Samaritan Medical Center, Phoenix, Ariz., and his colleagues.

In their study of 104 triplet gestations, the overall average prolongation of gestation was 57.4 days (8.2 weeks) with a combined course of oral and subcutaneous terbutaline from the first episode of threatened preterm labor until delivery.

The women were put on oral terbutaline after their first episode of threatened preterm labor and subsequently received continuous subcutaneous terbutaline after recurrence of preterm contractions was identified. Patients receiving subcutaneous terbutaline added an average of 37.7 days to their gestation period after their first instance of threatened preterm labor vs. 19.6 days for oral terbutaline therapy

The total daily dosage of terbutaline was 5.5 times lower with continuous subcutaneous infusion than with oral treatment.

The study did not have a control group and was not designed to determine the overall efficacy or safety of maintenance tocolysis.

COPYRIGHT 2002 International Medical News Group
COPYRIGHT 2002 Gale Group

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