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Tick paralysis

Tick paralysis is the only tick-borne disease that is not caused by an infectious organism. The illness is caused by a neurotoxin produced in the tick's salivary gland. After prolonged attachment, the engorged tick transmits the toxin to its human host. The incidence of tick paralysis is unknown. more...

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Signs and Symptoms

The toxin causes symptoms within 2-7 days, beginning with weakness in both legs that progresses to paralysis. The paralysis ascends upward to trunk, arms, and head within hours and may lead to respiratory failure and death. The disease can present as acute ataxia without muscle weakness.

Diagnostic Tests

Diagnosis is based on symptoms and upon finding an embedded tick, usually on the scalp.


Removal of the embedded tick usually results in resolution of symptoms within several hours to days. If the tick is not removed, the toxin can be fatal, with reported mortality rates of 10-12 percent.


No vaccine is currently available for any tick-borne disease. Individuals should therefore take precautions when entering tick-infested areas, particularly in the spring and summer months. Preventive measures include avoiding trails that are overgrown with bushy vegetation, wearing light-colored clothes that allow one to see the ticks more easily, and wearing long pants and closed-toe shoes. Tick repellents containing DEET (N,N, diethyl-m-toluamide) are effective and can be applied to skin or clothing. Although highly effective, severe reactions have occurred in some people who use DEET-containing products. Young children may be especially vulnerable to these adverse effects. Permethrin, which can only be applied to clothing, kills ticks on contact.


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Ticks May Fascinate Biologists, but the Blood Suckers Worry Health Officials - tick-borne diseases
From National Wildlife, 8/1/00 by Peter Jaret

The six-year-old girl was playing happily on a midsummer day when her fingers began to go numb. Soon she was staggering and falling. By the time her terrified parents rushed her to the Medical College of Georgia in Augusta, she could barely stand or sit up. As the doctors searched for a cause, the little girl's speech became slurred, her breathing labored. Baffled by the spreading paralysis, the medical team prepared to put her on a respirator.

Then a pediatrician, recalling something she had learned in medical school, took a fine-tooth comb and examined the girl's scalp. Hidden in the long blonde hair was what she had suspected: a blood-engorged tick, indicating that the symptoms might be from a rare disease called tick paralysis. The tick, Dermacentor variabilis, releases a toxin that interferes with nerve transmission. The girl's case, notable because tick paralysis is often confused with other disorders, was written up in a recent issue of The New England Journal of Medicine.

Tick paralysis is not the only tick-related ailment that can go undiagnosed. Most of the illnesses that ticks either directly cause in humans or infect them with have been identified only in the past 20 years. As more people choose to live close to wooded areas where ticks flourish, experts say, cases of these diseases are likely to increase. And the incidence of tick-borne infections may be on the rise in areas where oak and other forest trees are growing back, providing habitat for ticks and their hosts.

The most common disease carried by ticks is Lyme disease, first identified in the mid-1970s. In 1998, 16,801 Americans were diagnosed with Lyme disease, the highest number of cases ever reported. Transmitted by ticks infected with the bacterium Borrelia burgdorferi, Lyme disease can be treated with antibiotics if it's caught early. But if it goes undetected, it can lead to joint damage, heart irregularities and even neurological problems.

Rocky Mountain spotted fever, one of the first tick-borne infections to be identified, is the second most common. It strikes about 300 to 400 Americans a year, and as many as 5 percent of cases may prove fatal. Symptoms include high fever, muscle pain, malaise and hemorrhaging into the skin.

Then there's ehrlichiosis, which also causes severe flulike symptoms that can sometimes prove deadly. Two human forms of the disease were identified in the 1980s. Last year researchers added a third when a form of ehrlichiosis known to afflict dogs also showed up in humans. All told, about 600 Americans have been diagnosed with one or another form of ehrlichiosis since the disease was discovered.

Other tick-borne diseases in the United States include tularemia, which causes skin sores; Colorado tick fever, which usually results only in mild illness; and babesiosis, a rare but sometimes fatal disease caused by a protozoan. "Odds are there are other tick-borne illnesses out there that we haven't identified yet," says Lance Durden, an entomologist and cocurator of the U.S. National Tick Collection in Statesboro, Georgia.

What makes ticks the bearers of so much microbial bad news is their thirst for blood. Scientists have identified more than 850 tick species, and though their life cycles vary widely, all survive by drinking the blood of their hosts.

Consider Ixodes scapularis-also known as the black-legged or deer tick- which is the main vector for the Lyme disease bacterium in the United States. It drinks only three meals of blood during its entire life cycle, feeding each time on a different host. In midsummer, larval ticks emerge from eggs deposited the autumn before under leaves on the forest floor. At this stage, the creatures are no bigger than the period at the end of this sentence. Crawling on top of the leaf litter, they grab onto a passing reptile, bird or mammal and, burrowing their mouthparts into the skin, take their first blood meal.

Ticks are known to feed on at least 80 species of mammals or birds. A recent study in Sweden found that ticks can infest migratory birds, which can carry diseases thousands of miles, potentially introducing them to new locales.

One of the favorite dining spots for Ixodes scapularis is the white- footed mouse, a major reservoir for the form of bacteria, called a spirochete, that causes Lyme disease. In some parts of the Northeast, half of the mouse population carries the Lyme spirochete. When a tick dines on an infected mouse, the germ passes into the gut, where it remains for the rest of the tick's life.

After drinking their fill, immature ticks drop back to the forest floor and go through a molting stage, emerging the next spring as nymphs about the size of a pinhead. Now able to climb, they scale blades of grass or small saplings to wait for their next meal. Recent studies have found that a single tick can be infected with up to three different organisms that cause human disease-and it can transmit all three in one bite.

"There's no doubt ticks can be very dangerous," says entomologist Robert Lane of the University of California at Berkeley. "But for those of us who study them, they're also enthralling."

Once ticks reach the end of a leaf or branch, they engage in behavior called "questing"-extending their legs like antennae. When an animal, bird or person brushes past, ticks grab on. After finding a prime place to feast, they sink a pair of cutting implements, called cheliceral digits, into the skin. Inserting a syringelike hypostome, which is lined with backward-pointing teeth to lock it in place, they begin their feast. Feeding for three days to a week, a female tick can increase her weight as much as 200-fold, growing to the size of a jellybean. Then she falls to the ground, where she lays 1,500 to 2,000 eggs, starting the cycle again.

How can you avoid her offspring? In tick territory, wear long pants and long-sleeved shirts, preferably light-colored so that you'll be able to see any ticks that hitch a ride. Tuck your pants legs into your socks and put tape around where they meet. You also can spray your skin or clothing with a repellent containing DEET or your clothing with permethrin spray (for both sprays make sure to follow instructions and use only as much as you need). While hiking, stay to the middle of the trail.

Once you get home, inspect yourself. If you find a tick attached to your skin, don't panic. Most ticks don't carry disease organisms, and quickly removing those that do can prevent transmission. The safest way to remove a tick is to grab it with fine tweezers close to the skin and pull slowly straight out.

Afterward, make sure to keep an eye on the site. "Don't worry if a nickel- or dime-sized red patch appears after two to three days," says Michael Felz, a tick-borne disease expert at the Medical College of Georgia. "That's a normal immune reaction to the tick bite. But if a patch appears that is two inches across or bigger and lasts for more than one week, see your doctor right away; it could be a sign of Lyme disease."

Also call your doctor if you come down with flulike symptoms at any time during the month after getting a tick bite. Fever, achy muscles, headache or unusual fatigue are early warning signs of Rocky Mountain spotted fever and ehrlichiosis. And if you've been bitten by a tick and you're not sure how long it has been there-especially if you live in an area where tick-borne illnesses occur-call your doctor for advice.

Fortunately, antibiotics can eliminate most infections spread by ticks. A new vaccine, called LYMErix, helps protect against Lyme disease, although it is only 76 percent effective and requires three separate shots and follow-up boosters.

For the scariest of all tick-related illnesses, tick paralysis, the treatment is astoundingly easy: removal of the tick. Once the culprit is gone, the toxin stops flowing. One day after physicians at the Medical College of Georgia removed the tick from their six-year-old patient's scalp, she was fully recovered. "When a little girl is close to death one day and completely well the next," says Felz, "you can't help thinking of it as a miracle."

California writer Peter Jaret has perfected the art of tucking his pants in his socks before walking his dog.

"There's no doubt ticks can be very dangerous, but for those of us who study them, they're also enthralling."

COPYRIGHT 2000 National Wildlife Federation
COPYRIGHT 2000 Gale Group

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