Triazolam chemical structure
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Triazolam

Triazolam (Halcion®, Novodorm®, Songar®) belongs to benzodiazepine group of drugs. It is commonly prescribed for insomnia because of its fast onset of action, and also because its short half-life (approximately 3 hours) makes it ideal for this use because it thereby avoids morning drowsiness. more...

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In the past, Triazolam was commonly prescribed by physicians for people who frequently change time zones, such as business people and politicians going overseas. However, this practise has been discouraged because on occasion, these people would wake up with total amnesia and have no knowledge of where they were going. In rare cases, paranoia would ensue.

Questions exist about its safety because it has a fairly narrow therapeutic window. Also, some have suggested that it causes hallucinations, amnesia, paranoia and verbal and physical aggression.

Halcion belongs to the Pregnancy Category X of the FDA. This means that it is known to cause birth defects in the unborn baby. On October 2, 1991, the Committee on the Safety of Medicines (CSM) banned sales of Triazolam in the UK after concluding that it had a higher frequency of psychiatric side-effects than other hypnotics (sleeping pills). Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.

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Halcion causes problems for elderly - triazolam
From Healthfacts, 9/1/88 by Arthur A. Levin

HALCION CAUSES PROBLEMS FOR ELDERLY

Asingle dose of the drug Halcion (generic name: triazolam), a best-selling sedative-hypnotic, has been reported to have cause delirium, short-term amnesia and involuntary body movements in five hospitalized elderly people (Physician's Drug Alert, July 1988). The sleep-inducing drug is routinely given to hospitalized patients because of its rapid action and short half-life, according to John F. Matterson, M.D., a psychiatrist at the University of Missouri. (Half-life is the time it takes the body to eliminate a drug to a blood level half of its peak amount. A short half-life is thought to minimize drug "hangover" common to longer-acting drugs like Valium.) Halcion made the news earlier this year with reports that it caused temporary amnesia in three middle-aged men who had taken the drug to minimize the effects of jet lag (see HealthFacts, January 1988).

COPYRIGHT 1988 Center for Medical Consumers, Inc.
COPYRIGHT 2004 Gale Group

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