Chemical structure of Valine
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Valine is one of the 20 natural amino acids, and is coded for in DNA. Nutritionally, valine is also an essential amino acid.

In sickle-cell disease, it subsitutes for the hydrophilic amino acid glutamic acid in hemoglobin: Because it is hydrophobic, the hemoglobin does not fold correctly.

Valine is uncharged overall, as its R group is neutral, and the charges from its amino and carboxylic acid groups balance out: a zwitterion.

Foods that are good sources of valine include cottage cheese, fish, poultry, beef, peanuts, sesame seeds, and lentils.

Valproate semisodium
Valproic acid
Vecuronium bromide


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MHP files patent: new protein technology; Increases anabolic/anti-catabolic effects for extreme muscle building!
From Flex, 12/1/05

After 4 years of research and development, the Senior Research Staff at MHP has pioneered a major breakthrough in protein supplementation. Their PROBOLIC-SR bio-engineered protein enhances bio-availability, amino acid levels and nitrogen retention for maximum anabolic effects to trigger extreme muscle growth unlike any other protein.

PROBOLIC-SR has literally set new standards in protein quality, bio-availability and its anabolic and anti-catabolic potential. This advanced bio-engineered protein utilizes patented technologies to overcome protein's natural limitations on nitrogen retention and muscle growth.

PROBOLIC-SR is the first and only protein bio-engineered to supply adequate amounts of nitrogen on a continual basis to create the needed anabolic/anti-catabolic environment for Hyperbolic Muscle Growth. Protein is an essential element for building muscle tissue, but muscle growth can only occur if your body retains more nitrogen (from protein) than your body loses through the ongoing process of nitrogen-excretion. This creates an anabolic state referred to as "positive nitrogen balance". On the contrary, without an adequate continual supply of protein (nitrogen), your body goes into a catabolic state of "negative nitrogen balance" and muscle loss will occur. Bodybuilders and athletes are particularly at risk because heavy exercise leads to increased nitrogen loss and muscle breakdown. So, the solution to preventing muscle wasting and packing on huge amounts of muscle seems simple--consume large amounts of protein to continually be in an anabolic "muscle building" state of positive nitrogen balance. Yet, most of you who workout take protein supplements religiously and eat a lot of protein, but you aren't packing on muscle the way science defines protein's (nitrogen) anabolic effects on muscle growth. WHY? This is where the science behind PROBOLIC-SR sets it apart from all other proteins and overcomes protein's anabolic limitations.

Overcoming Protein's Limitations to Enhance Muscle Growth!

Protein's limitations on achieving and maintaining the anabolic environment needed to augment large increases in muscle mass has remained a mystery to the scientific community. If a positive nitrogen balance (from protein) is the needed anabolic stimulus for muscle growth and if anabolic agents like steroids and HGH exert tremendous gains in muscle mass just by increasing nitrogen retention, then why doesn't consuming large amounts of high quality proteins like whey, casein, soy and egg produce the expected gains in muscle mass? MHP's Senior Research Staff was determined to find out why these scientific principles of protein as a highly anabolic nitrogen source did not hold true once consumed.

In the development of PROBOLIC-SR, MHP researchers analyzed every known natural source of protein for their Amino Acid Composition (AAC), Biological Value (BV), Protein Digestibility Correct Amino Acid Score (PDCAAS), Protein Efficiency Ratio (PER) and Rate of Absorption (RA)-the rate in which the protein releases amino acids. They also analyzed the amino acid composition of human muscle tissue and the effects of resistance training on nitrogen depletion and muscle tissue remodeling. Their findings uncovered many myths and misconceptions about protein, which helped them understand why protein did not meet its anabolic expectations. It also lead them to the realization that no existing protein in nature was capable of exerting these desired anabolic effects and the only way to achieve the nitrogen retention needed the desired anabolic effects was to bio-engineer a protein to make up for protein's natural deficiencies.

The Breakthroughs Behind PROBOLIC-SR

The two biggest challenges in bio-engineering a more powerful anabolic protein were altering the protein's amino acid composition and release rate. However, after years of research and development, MHP researchers made two of the biggest breakthroughs in the history of protein manufacturing. These breakthroughs were identifying the anabolic Critical Five Amino Acids (CFAAS) and the introduction of a patented sustained release delivery system, MICRO-FEED TECHNOLOGY!

'CFAAS' Setting New Standards in Amino Acid Scores.

The World Health Organization and protein manufacturers use a methed known as PDCAAS (Protein Digestibility Correct Amino Acid Score). Protein manufacturers have been using this method to determine the value of their proteins and while many proteins such as whey, casein, say and egg all have perfect scores of 100, MHP's researchers see two major flaws with this method relative to bodybuilders and muscle growth. Those flaws being that this score is based on pre-school children's protein needs. We know that an adult bodybuilder's protein needs are far greater than those of a pre-school child. Perhaps an even bigger flaw is this score only takes into account essential amino acids and does not include the very important "conditionally essential" amino acids arginine and glutamine.

From their extensive research on evaluating the amino acid composition of protein and muscle tissue, it was determined that the five most important aminos for muscle growth in response to training are glutamine, arginine and the Branched Chain Amino Acids--leucine, isoleucine and valine. These amino acids provide the highest anabolic response and are needed to support muscle tissue remodeling in response to heavy training. These 5 amino acids are what the protein industry is now calling the Critical Five and they have established a new standard in measuring the value of a protein. This new method is called the Critical Five Amino Acid Score (CFAAS), which measures the amount of these very important amino acids in a protein source.

Glutamine: The most abundant amino acid found in muscle tissue makes up approximately 60% of all muscle. Glutamine levels are rapidly depleted during exercise and if optimal levels are not in the body, muscle breakdown and loss will occur. Glutamine is known to promote anabolic conditions in muscle cells and increase the rate of protein synthesis, increase the cell volume of your muscles, aid in recovery, prevent muscle breakdown and spur the release of HGH.

BCAAs (Branched Chain Amino Acids--leucine, isoleucine and valine): The next most abundant amino acids found in muscle tissue make up approximately 33% of all muscle. BCAAs are heavily catabolized (broken down and used for energy) during exercise. If adequate amounts of BCAAs are not available during exercise, your body uses valuable muscle tissue for fuel. Unfortunately, the body cannot make it's own BCAAs and there is a dramatic increase in the need for BCAAs for people working out. By maintaining optimal levels of BCAAs through supplementation, you can protect muscle, improve recovery and endurance and maximize muscle growth.

Arginine (Nitro loading): Increases Nitric Oxide production, which is the muscle's "cell-signaling" molecule responsible for blood flow (hemodilation), oxygen delivery, nutrient delivery and uptake (amino acids and glucose), muscle velocity, power output and muscle-growth. The increased blood flow supplies more protein and nutrients to your muscles for increased size, fuller and thicker muscles, full body pumps, strength, vascularity and improved recovery. Arginine has also been shown to trigger HGH release.

Patented Micro-Feed Technology The 12 Hour Muscle Feeder!

Improves Protein's Bio-availability for Better Utilization and Increases Anabolic/Anti-catabolic Effects for Maximum Muscle Growth!

The patented Micro-Feed Technology is the biggest breakthrough ever in protein supplementation. This pharmaceutical delivery system is designed to provide a continual supply of amino acids for up to 12 hours! The Micro-Feed Technology works like an IV drip continually supplying a "metered dose" of high concentrations of Critical Five Amino Acids so that you always stay in an extremely anabolic muscle building state and never slip into a catabolic state. This technology also increases bio-availability making full 100% utilization of every gram of protein "NO WASTED PROTEIN-NO WASTED MUSCLE!"

To fully appreciate just how important this Micro-feed Technology breakthrough is, let us fill you in on some of MHP's findings regarding protein's true Biological Value, utilization and ability to maintain a positive nitrogen balance.

The protein industry and scientists have been using Biological Value (BV) as a measure of protein quality. Many proteins such as whey and whole egg are given a perfect score of 100, which suggests that every gram ingested is utilized. NOT SO--our findings found that these values are based on low dose consumption (only 9-18 grams of protein). When larger doses are taken, such as 40-60 grams, the amount commonly consumed by bodybuilders, not all of the protein is utilized and some of it is converted to the waste products urea and ammonia. This helps explain why large dose protein consumption doesn't produce the desired anabolic effects you might expect.

The research also found that the varying release rates of proteins influence their Biological Value, utilization and ability to supply nitrogen. While the whey industry has done a good job trying to lead you to believe faster is better in terms of release rates, new studies show that slower releasing proteins provide greater anabolic and anti-catabolic effects. Therefore, the ideal protein would provide fast, medium and slow release rates. It is important to realize that when it comes to building muscle, anti-catabolic properties are just as important as anabolic properties. In fact, most doctors and scientists credit the anti-catabolic effects of steroids to be more responsible for the gains in muscle than their anabolic effects.

The Anytime Anabolic Protein Exclusive 4-Stage Release

PROBOLIC-SR is the only protein in existence to provide a 4-stage delivery, making it the ideal anytime protein. The precisely formulated blend of proteins provides a fast, medium and slow release of Amino Acids and is further prolonged with the patented Micro-Feed Technology! This advanced release profile supplies the needed quick release (0-2 hours) of amino acids for post-workout replenishment of nitrogen. It is also perfect for pre-workout because its medium and slower release (hours 2-6) will keep supplying aminos and keep you in an anabolic state throughout your entire workout and prevent going into a catabolic state. When taken before bedtime PROBOLIC-SR's Micro-Feed Technology will supply high levels of the Critical Five Aminos and keep you anabolic all night! PROBOLIC-SR will ensure you never slip into catabolism between meals, during workouts or during the night while you sleep and always keep you in "positive nitrogen balance" and anabolic overdrive!


* Feeds Muscle Tissue for 12 Hours

* Increases Anabolic Effects

* Prevents Catabolic Muscle Wasting

* Improves Protein's Bio-availability

* Highest Levels of the Critical Five Amino Acids


In the development of Probolic-SR, MHP's research staff developed a precisely formulated protein matrix of Whey, Supro[R] and Casein to provide the highest possible levels of Critical Five Amino Acids and essential amino acids. To get an even stronger anabolic response, they further enhanced this matrix with even more free form glutamine, arginine, isoleucine, leucine and valine making Probolic-SR by far the most concentrated source of the Critical Five Amino Acids (CFAAs).

RELATED ARTICLE: Probolic-SR (60 Grams) VS. Whey Isolate (60 Grams)

This graph illustrates how important this new-patented Micro-Feed Technology is to the development of Probolic-SR. Without this technology, there would be no way to ensure the constant supply of essential and Critical Five Amino Acids required to maintain a positive nitrogen balance and prevent catabolism, all the things needed to create the anabolic environment for "Hyperbolic Muscle Growth".

RELATED ARTICLE: When Other Proteins Stop Working, Probolic-SR Keeps Feeding Muscle Tissue For 12 Straight Hours!

PROBOLIC-SR's is by far the most anabolic/anti-catabolic protein and has literally changed the properties of protein and made all other proteins inferior and obsolete!

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COPYRIGHT 2005 Weider Publications
COPYRIGHT 2005 Gale Group

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