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Valsartan

Valsartan (Diovan®) is an angiotensin II receptor antagonist, acting on the AT1 subtype. It is used to treat high blood pressure, congestive heart failure, and may be used to treat chronic renal failure.

Administration

Oral tablets, containing 40 mg, 80 mg, 160 mg or 320 mg of valsartan. Usual dosage ranges from 40-320 mg daily. Diovan HCT® contains a combination of valsartan and hydrochlorothiazide.

Side effects

Most commonly, headache and dizziness.

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Replacement of valsartan and candesartan by telmisartan in hypertensive patients with type 2 diabetes: metabolic and antiatherogenic consequences.(Observation s) : An article from: Diabetes Care $5.95 FDA Panel Splits Over CHF Indication for Valsartan. (Concern About Use With [beta]-Blockers).(congest ive heart failure) : An article from: Internal Medicine News $5.95
Use of ARB lowers incidence of new-onset diabetes: but valsartan and amlodipine had equal effect on cardiac mortality, morbidity.(News) : An article from: Family Practice News $5.95 Addition of valsartan to an angiotensin-converting enzyme inhibitor improves cardiac sympathetic nerve activity and left ventricular function in patients ... from: The Journal of Nuclear Medicine $20.00
Benefits of Valsartan, Cardiology $16.21 Valsartan matches Captopril in post-MI patients: preventing deaths after MI.(Cardiovascular Medicine) : An article from: Internal Medicine News $5.95
Diovan. (New & Approved).(valsartan from Novartis for the treatment of heart failure)(Brief Article) : An article from: Family Practice News $5.95 Valsartan matches captopril after MI: preventing deaths. (myocardial infarction, the medical term for a heart attack).(Clinical Rounds) : An article from: Family Practice News $5.95

VALUE trial — 23% drop in new-onset diabetes with valsartan
A 23% relative risk reduction in new-onset diabetes over 4 years was observed in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial ...
From Diabetes and Primary Care, 9/22/04
VALUE trial—23% drop in new-onset diabetes with valsartan
A 23% relative risk reduction in new-onset diabetes over 4 years was observed in the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial ...
From Journal of Diabetes Nursing, 6/1/04
Valsartan an alternative to ACE inhibitor in high-risk MI - Meeting highlights: Annual Scientific Sessions, American Heart Association Orlando, Florida,
The angiotensin receptor blocker (ARB) valsartan can be considered a clinically effective alternative to the ACE inhibitor captopril following myocardial ...
From Geriatrics, 1/1/04
Valsartan improves survival for patients with heart failure
Valsartan, an angiotensin II receptor blocker, is a safe and effective alternative for patients with heart failure who can't take angiotensin-converting ...
From Nursing, 2/1/03
Valsartan Reduces Death and Morbidity in Heart Failure Patients
(73rd Scientific Sessions of the American Heart Association) According to results of the Valsartan Heart Failure Trial (Val-HeFT), the combined risk of death and morbidity in patients with heart fai
From American Family Physician, 5/15/01 by Jay N. Cohn
Olmesartan for hypertension
Synopsis Olmesartan (Benicar) is an angiotensin-II receptor blocker (ARB) labeled for the treatment of hypertension as monotherapy or in combination ...
From American Family Physician, 8/15/05 by Kristina E. Ward
What is the best regimen for newly diagnosed hypertension?
EVIDENCE-BASED ANSWER Low-dose thiazide diuretics (eg, hydrochlorothiazide 12.5 to 25 rag/d) are the best first-line pharmacotherapy for treating ...
From Journal of Family Practice, 3/1/05
Ask the Experts
Q Are angiotensin-receptor blockers (ARBs) equivalent to or better than angiotensin-converting enzyme (ACE) inhibitors in the treatment of heart failure?
From Critical Care Nurse, 12/1/04 by Juanita Reigle

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