Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. As with other α2 agonists, adverse effects include bradycardia, conduction distrubances, and myocardial depression. Yohimbine (Yobine) can be used to reverse xylazine effects. In the laboratory setting, xylazine is often used in combination with ketamine.