Find information on thousands of medical conditions and prescription drugs.

Zoledronic acid

Zoledronate (Zometa®, Novartis) is a bisphosphonate, used to prevent osteoporosis and skeletal fractures, particularly in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia, particularly hypercalcemia of malignancy. It can also be helpful for treating pain from bone metastases. more...

Home
Diseases
Medicines
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Zafirlukast
Zagam
Zalcitabine
Zaleplon
Zanaflex
Zanamivir
Zantac
Zarontin
Zelnorm
Zerit
Zestoretic
Zestril
Zetia
Zevalin
Ziagen
Zidovudine
Zileuton
Ziprasidone
Zithromax
Zocor
Zofran
Zoladex
Zoledronic acid
Zolmitriptan
Zoloft
Zolpidem
Zometa
Zomig
Zonegran
Zonisamide
Zopiclone
Zosyn
Zovia
Zovirax
Zyban
Zymar
Zyprexa
Zyrtec
Zyvox

Administration

Usually 4 mg intravenously once a month when given for oncologic purposes. It is given once a year for treatment of osteoporosis.

Side effects

Side effects can include fatigue, anemia, muscle aches, fevers, and swelling in the feet or legs. Zoledronate can cause deterioration in renal function.

A rare complicaiton of zoledronate is osteonecrosis of the jaw. This has mainly been seen in patients with multiple myeloma treated with zoledronate (Durie et al 2005).

Contraindications

  • Poor renal function (e.g. creatinine>3 mg/dL)
  • Pregnancy

Reference

  • Durie BG, Katz M, Crowley J. Osteonecrosis of the jaw and bisphosphonates. N Engl J Med 2005;353:99-102. PMID 16000365.

Read more at Wikipedia.org


[List your site here Free!]


Volunteers needed for trial - FYI
From OB/GYN News, 2/15/03

Investigators are recruiting volunteers for a trial of a once-yearly infusion of zole-dronic acid for the treatment of osteoporosis. The program also will evaluate the effectiveness of a single dose of zoledronic acid given once for the treatment of Paget's disease. Women aged 65-89 years with osteoporosis and men and women aged 50 years and older who have documented osteoporosis are eligible to participate. To enroll, contact Novartis, 877-YHORIZON or www.horizon.novartis.com.

COPYRIGHT 2003 International Medical News Group
COPYRIGHT 2003 Gale Group

Return to Zoledronic acid
Home Contact Resources Exchange Links ebay