It is an isomer of hypoxanthine and inhibits the production of uric acid, the metabolite responsible for gout, by inhibiting the enzyme xanthine oxidase.

Allopurinol can also be given with some cancer treatments that increase uric acid (tumor lysis syndrome), as well as for kidney stones. These treatments result in large numbers of cells being disposed of by the body, which releases uric acid as part of the breakdown of DNA.

Allopurinol is an analog of the natural purines in the body, and is quickly metabolised to oxipurinol which is also a xanthine oxidase inhibitor.

The side effects of high levels of precursors are usually minor. A small percentage of people develop a rash and must discontinue this drug. The most serious adverse event is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, and worsening renal function. In some cases, allopurinol hypersensitivity syndrome can be fatal.

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	Gale Encyclopedia of Cancer : Allopurinol $3.10	Allopurinol doesn't work? Here's how to lower urate.(Musculoskeletal Disorders) : An article from: Family Practice News $5.95

	Allopurinol - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References $34.95


Allopurinol Definition This medication, also known as (Zyloprim), is used for the treatment and prevention of gout attacks and certain types of kidney stones. From Gale Encyclopedia of Cancer, by Pharm.D. Olga Bessmertny

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