Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.

Clinical use

Aminocaproic acid is used to treat excessive postoperative bleeding. It can be given orally or intravenously. One scenario where it may be useful is to treat bleeding after dental extractions in patients with hemophilia, because the oral mucosa is rich in plasminogen activators. A meta-analysis found that lysine analogs like aminocaproic acid significantly reduced blood loss in patients undergoing coronary artery bypass grafting.

Side effects

Its side effects are mainly related to the gastrointestinal tract and include nausea, vomiting, abdominal pain, and diarrhea. The main risk associated with aminocaproic acid is the increased risk for thrombosis because of the inhibition of fibrinolysis.

Read more at Wikipedia.org

• [List your site here Free!]



	Prophylactic treatment of postperfusion bleeding using EACA - episol aminocaproic acid To determine the effects of prophylactic treatment with EACA for blood loss after cardipulmonary bypass surgery, 350 consecutive patients undergoing ... From CHEST, 7/1/89 by Anthony J. DelRossi

	Tranexamic acid in paediatric cardiac surgery Background & objectives: Antifibrinolytic agents are used commonly in adult cardiac surgery to reduce postoperative blood loss. Paucity of literature on the use of a newer antifibrinolytic agent tran From Indian Journal of Medical Research, 8/1/03 by Chauhan, Sandeep

	How to Reduce Blood Loss During Cardiac Surgery Excessive bleeding is a major cause of morbidity and mortality associated with cardiac surgery. Many strategies have been suggested to minimize perioperative ... From American Family Physician, 3/1/00 by Anne D. Walling

	Coagulation activation and organ dysfunction following cardiac surgery Study objectives: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the ... From CHEST, 7/1/05 by Barry Dixon

	Use of recombinant activated factor VII for bleeding following operations requiring cardiopulmonary bypass Postoperative bleeding is a common complication following cardiothoracic surgical procedures requiring cardiopulmonary bypass (CPB). Serious bleeding ... From CHEST, 5/1/05 by Robert J. DiDomenico

	Use of extracorporeal membrane oxygenation in a patient with diffuse alveolar hemorrhage Extracorporeal membrane oxygenation (ECMO) was developed as a supportive therapy for severe respiratory failure. It has been shown to be life-saving ... From CHEST, 7/1/04 by S. Hinan Ahmed

	Extending the uses of ECMO Few treatment modalities for the critically ill have experienced a roller coaster ride like the use of extracorporeal membrane oxygenation (ECMO). At ... From CHEST, 7/1/04 by Thomas R. Weber

	Characterization of plasmin(ogen) binding to Streptococcus pneumoniae Background & objectives: The proteolytic activity of plasmin promotes migration of pathogenic bacteria through the human extracellular matrix. The human ... From Indian Journal of Medical Research, 5/1/04 by Bergmann, Simone

Home

Contact

Resources

Exchange Links

ebay