The structure of 5-azacytidine
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Azacitidine

5-azacytidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Cells in the presence of 5-azacytidine incorporate it into DNA during transcription and RNA during translation. The incorporation of 5-azacytidine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence, affecting the way that cell regulation proteins are able to bind to the DNA/RNA substrate.

5-azacytidine is mainly used in the treatment of myelodysplastic syndrome. It is marketed as Vidaza.


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Gale Encyclopedia of Cancer : Azacitidine $1.50 Azacitidine: A novel drug for myelodysplastic syndrome.(Molecules of the Millennium) : An article from: Indian Journal of Pharmacology $5.95

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